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Which mouth spray eases wisdom tooth pain best? new study tests two options

NCT ID NCT07416136

Symptom relief Sponsor: Marmara University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested two different mouth sprays to see which works better for pain, swelling, and jaw stiffness after removing impacted lower wisdom teeth. Forty adults each had both surgeries, receiving one spray after each. Neither patients nor evaluators knew which spray was used. The goal is to improve recovery after wisdom tooth surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Chlorhexidine gluconate + benzydamine hydrochloride spray and chlorhexidine gluconate + flurbiprofen spray
What this could lead to
If one spray works better, it could offer a simple way to ease pain and swelling after wisdom tooth surgery.
What could go wrong
This is a small, early study with only 40 people. Results may not apply to everyone, and the sprays might not differ much in effectiveness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Apr 2025

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged between 18 and 50 years * Indication for bilateral impacted mandibular third molar extraction * ASA physical status I or II * No antibiotic use within the previous two weeks * No analgesic use within the previous 12 hours * Ability to provide written informed consent Exclusion Criteria: * ASA physical status III to V * Pregnancy or breastfeeding * Known allergy to chlorhexidine, benzydamine, or flurbiprofen * Smoking more than one pack per day * History of substance abuse * Presence of systemic diseases that may affect wound healing

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Impacted mandibular third molar

Contacts and locations

Locations

  • Marmara Unıversity Faculty of Dentistry

    Istanbul, Maltepe, 34840, Turkey (Türkiye)

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