Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Brain scans reveal clues to uneven muscle weakness in progressive MS

NCT ID NCT04918225

Knowledge-focused Sponsor: Rennes University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 46 people with progressive multiple sclerosis who have more weakness on one side of their body. Researchers used MRI scans to see how damage in the brain and spinal cord relates to muscle strength in each limb. The goal was to better understand what causes physical disability in progressive MS.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

46 people

The number who actually took part.

Started

Nov 2021

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patient population will consist of progressive Multiple Sclerosis patients (both Primary Progressive Multiple Sclerosis and Secondary Progressive Multiple Sclerosis), a population for whom a better understanding of the causes of disability is an unmet need.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

1. \- Inclusion Criteria: 1.1/ Patients: * Aged between 18 and 60 years. * Primary Progressive Multiple Sclerosis or Secondary Progressive Multiple Sclerosis as defined by Mac Donald revised criteria in 2017. * Expanded Disability Status Scale lower or equal to 8.0, at inclusion. * asymmetric motor deficit. The motor deficit asymmetry will be defined by a difference of 3 or more at the American Society Injury. Association motor sub-score per limb between the right lower limb and the left lower limb. * No evidence of focal inflammatory activity for at least 3 years (no clinical relapse, no gadolinium enhancement on an Magnetic Resonance Imaging scan and no new T2 lesion) * Provided written informed consent according to the Institutional review board approval * Affiliated to the French healthcare system. 1.2 / Controls: * Aged between 18 and 60 years, sex and age matched with patients. * Provided written informed consent according to the Institutional review board approval * Affiliated to the French healthcare system. 2. \- Non-inclusion criteria: 2.1 /Patients: * cerebellar Expanded Disability Status Scale sub score higher than pyramidal Expanded Disability Status Scale sub score. * Relapse or corticosteroids in the 30 days preceding inclusion. * Other neurological diseases. * Lack of ability to understand the Institutional review board consent form. * Magnetic Resonance contraindications. * Pregnancy and breastfeeding. * Major persons subject to legal protection (legal safeguards, guardianship,curatorship), persons deprived of their liberty 2.2 / Controls: * Personal history of central nervous related disease * Familial history of Multiple Sclerosis. * Personal history of spinal cord injury. * Personal history of spondylotic myelopathy. * Magnetic Resonance Imaging contraindication. * Lack of ability to understand the Institutional review board form. * Major persons subject to legal protection (legal safeguards, guardianship, curatorship), persons deprived of their liberty * Pregnancy and breastfeeding.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Multiple sclerosis, primary progressive are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

chronic progressive multiple sclerosis primary progressive multiple sclerosis secondary progressive multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Multiple sclerosis, primary progressive Multiple sclerosis, secondary progressive

Contacts and locations

Locations

  • CHU de Rennes - Hôpital Pontchaillou

    Rennes, 35033, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.