New drug combos show promise in shrinking head and neck tumors before surgery

NCT ID NCT05459129

Completed Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 24, 2026 · Updated 29 times

Summary

This study tested several drug combinations in 12 people with advanced head and neck cancer that had not been treated yet. The goal was to see if the drugs could make tumors disappear or shrink before surgery. The study is now complete, and the results help guide future treatment options.

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Contacts and locations

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Locations

Asan Medical Center

Seoul, 05505, South Korea
City of Hope

Duarte, California, 91010, United States
Hadassah University Hospital - Ein Kerem

Jerusaelm, 9112001, Israel
Severance Hospital - Yonsei Cancer Center

Seoul, 03722, South Korea
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15213, United States

Conditions

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SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK