Study probes what makes smokeless tobacco so addictive
NCT ID NCT06249984
First seen Jun 27, 2026 · Last updated Aug 18, 2026 · Updated 2 times
Summary
This study looks at how the cut (fine vs. long) and nicotine form in moist snuff affect how addictive it is. Researchers will study 80 moist snuff users to see how these features influence how much people use it, how fast nicotine enters the body, and how appealing the product is. The goal is to provide evidence that could lead to regulations to reduce the addictiveness of smokeless tobacco.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 80 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2024
- Expected to finish
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Jan 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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21 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults aged 21 and older who reside in Appalachian counties and surrounding rural areas under the RUCA code 10 classification and use SLT daily for at least 3 months and using 1.5 cans/week will be considered for this project * Established moist snuff user (has used moist snuff daily for at least the past 3 months, uses at least 1.5 cans/week. * Age 21 years or older * Reside in Appalachian counties and surrounding rural areas under the RUCA code 10 classification * Willing to complete 5 study visits and provide informed consent study procedures, including abstaining from all tobacco, nicotine, and marijuana for 12 hours before clinic visits * Willing to abstain from nicotine and tobacco products 12-hours before study visit * Ability to read and speak English Exclusion Criteria: * Pregnant, planning to become pregnant, or breastfeeding (will be verified with a urine pregnancy test at the first session visit) * Unstable or significant psychiatric conditions (past and stable conditions will be allowed) * History of cardiac event or distress, including but not limited to uncontrolled high blood pressure, chest pain, and shortness of breath, within the past 3 months * Working with a cessation counselor, using cessation devices such as Chantix or Wellbutrin, or planning to quit within the next 3 months * Severe periodontal or oral lesions
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Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The study's own enquiry address
This study publishes an address for enquiries. See it below .
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
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Contacts and locations
Show contact details
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Genom att skicka in godkänner du våra Användarvillkor
Study contacts
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Contact
Email: •••••@•••••
Locations
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Center for Tobacco Research
RECRUITINGColumbus, Ohio, 43214, United States
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Ohio State University Comprehensive Cancer Center
NOT_YET_RECRUITINGColumbus, Ohio, 43210, United States
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