Chinese kids with hodgkin lymphoma get tailored chemo combo in new trial
NCT ID NCT04726501
First seen Mar 21, 2026 · Last updated Jun 20, 2026 · Updated 18 times
Summary
This phase 4 study tests a modified chemotherapy regimen (based on a U.S. protocol) in 200 Chinese children and teens with newly diagnosed Hodgkin lymphoma. Depending on risk level, patients receive 4 to 6 cycles of chemotherapy, with or without low-dose radiation. The goal is to see if this approach improves event-free and overall survival compared to past outcomes in China.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Nanjing Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Nanjing, China
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Shanghai Children's Medical Center
Shanghai, 200127, China
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West China Second University Hospital, Sichuan University, Chengdu, China
Chengdu, China
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Combination chemotherapy (AVE-PC or ABVE-PC) with or without involved-field radiotherapy
What this could lead to
If successful, this could confirm that a modified COG protocol works well for Chinese children with Hodgkin lymphoma, potentially improving event-free and overall survival rates.
What could go wrong
This is a single-country, non-randomized study with a relatively small sample size (200 participants). Results may not apply to other populations, and chemotherapy carries risks like infection and organ damage.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.