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Computer-Guided dosing may help sick kids get the right antibiotic dose

NCT ID NCT07315438

Knowledge-focused Sponsor: Hacettepe University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a computer-assisted method called Model-Informed Precision Dosing (MIPD) to give the right amount of two strong antibiotics (vancomycin and amikacin) to 41 critically ill children. Standard weight-based dosing often misses the target in these kids because their bodies change quickly. The approach aimed to see if using a computer model could predict drug levels more accurately than usual care, potentially improving treatment and reducing side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

41 people

The number who actually took part.

Started

Dec 2023

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

38 to 81 months

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Hospitalized patients (NICU) receiving vancomycin or amikacin * Treatment with vancomycin or amikacin initiated during hospitalization * At least one therapeutic drug monitoring (TDM) measurement obtained Exclusion Criteria * Failure to obtain written informed consent * Death within the first 24 hours after treatment initiation * Discontinuation of therapy before the first TDM measurement * Determined unsuitable for study participation by the treating physician

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Model informed precision dosing

Contacts and locations

Locations

  • Hacettepe University

    Ankara, 06100, Turkey (Türkiye)