New antibody ring aims to prevent pregnancy without hormones
NCT ID NCT06740253
First seen Jun 27, 2026 · Last updated Sep 21, 2026 · Updated 1 time
Summary
This study tested a new type of vaginal ring that uses antibodies to block sperm, instead of hormones, to prevent pregnancy. Fourteen healthy women used a placebo version of the ring to see if it was safe and comfortable. The goal was to gather early feedback on the device's design and how well women could follow the instructions.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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14 people
The number who actually took part.
- Started
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Feb 2025
- Finished
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Jul 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 45 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Provide written informed consent 2. Age of 18 - 45 years at enrollment 3. Female participants, born female 4. Willing and able to * communicate in English * complete all required study procedures 5. Subjects willing to abstain from vaginal intercourse and use of vaginal products for the first week of the study and until cleared by the study physician. Exclusion Criteria: Participant reports any of the following: 1. Gynecologic or genital procedure (e.g., tubal ligation, dilation and curettage, piercing) within 21 days prior to Enrollment Note: Colposcopy and cervical biopsies for evaluation of an abnormal Pap smear as well as IUD removal are not exclusionary 2. Current use of an IVR (e.g., Nuvaring) 3. Prior hysterectomy 4. Females who are pregnant based on positive pregnancy test by urine HCG 5. Cervicovaginal inflammation or epithelial disruption on colposcopy at the screening examination. 6. Current active gynecological abnormalities or sexually transmitted infection and/or vaginal pathogens (e.g. gonorrhea, chlamydia, mycoplasma genitalium, trichomonas, candida species, bacterial vaginosis) at the screening examination. Note: Subjects may be treated and re-screened for participation. 7. Has any other condition or is participating in another research study that, in the opinion of the Principal Investigator or designee, would preclude informed consent, make study participation unsafe, complicate interpretation of study outcome data, or otherwise interfere with achieving study objectives.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Texas Medical Branch
Galveston, Texas, 77555, United States