New hope for tough prostate cancer: experimental drug takes on standard treatments
NCT ID NCT06136624
First seen Jun 25, 2026 · Last updated Sep 04, 2026 · Updated 7 times
Summary
This large Phase 3 trial is testing a new oral drug called opevesostat (MK-5684) against two standard drugs (abiraterone or enzalutamide) in men with metastatic castration-resistant prostate cancer that has worsened after prior hormone therapy and chemotherapy. The study aims to see if opevesostat helps patients live longer. About 1,310 men will participate at multiple sites.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Opevesostat (MK-5684)
- What this could lead to
- If successful, this could offer a new treatment option for men with advanced prostate cancer that has stopped responding to standard hormone therapy and chemotherapy.
- What could go wrong
- This is an early-stage Phase 3 trial, so results are not yet known. The new drug may not improve survival or could have side effects that outweigh benefits.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 1,310 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2023
- Expected to finish
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Feb 2030
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Has histologically- or cytologically-confirmed adenocarcinoma of the prostate without small cell histology. * Has prostate cancer progression while on androgen deprivation therapy (or post bilateral orchiectomy) within 6 months before Screening * Has current evidence of distant metastatic disease (M1 disease) documented by either bone lesions on bone scan and/or soft tissue disease by computed tomography/magnetic resonance imaging (CT/MRI). * Has disease that progressed during or after treatment with 1 novel hormonal agent (NHA) * Has received 1 but no more than 2 taxane-based chemotherapy regimens for metastatic castration-resistant prostate cancer (mCRPC) and has had progressive disease (PD) during or after treatment * Has ongoing androgen deprivation with serum testosterone \<50 ng/dL (\<1.7 nM) * Has provided tumor tissue from a fresh core or excisional biopsy from soft tissue not previously irradiated * Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 assessed within 7 days of randomization * Has had prior treatment with PARPi or were deemed ineligible to receive treatment by the investigator or have refused PARPi treatment * Has received prior 177Lu-PSMA-617 or were deemed ineligible to receive 177Lu-PSMA-617 treatment by the investigator or refused 177Lu-PSMA-617 treatment * Participants who have not received cabazitaxel can be enrolled if they are ineligible for cabazitaxel treatment as determined by the investigator or have refused treatment * If participant received first generation anti-androgen therapy before screening, the participant has evidence of disease progression \>4 weeks since the last flutamide treatment and \>6 weeks since the last bicalutamide or nilutamide treatment * Participants receiving bone resorptive therapy (including, but not limited to, bisphosphonate or denosumab) must have been on stable doses for ≥ 4 weeks before the date of randomization * Participants with human immunodeficiency virus (HIV) infection must have well controlled HIV on antiretroviral therapy (ART) * Participants who are hepatitis B surface antigen (HBsAg) positive are eligible if they have received hepatitis B virus (HBV) antiviral therapy for at least 4 weeks and have undetectable HBV viral load before randomization * Participants with history of hepatitis C virus (HCV) infection are eligible if HCV viral load is undetectable at Screening. * Participants who can produce sperm must agree to the following during the study treatment period and for at least 7 days after the last dose of opevesostat, for at least 30 days after the last dose of abiraterone acetate, and for at least 3 months after the last dose of enzalutamide: EITHER be abstinent OR must agree to use male condom Exclusion Criteria: * Has a gastrointestinal disorder that might affect absorption * Has a history of pituitary dysfunction * Has poorly controlled diabetes mellitus * Has clinically significant abnormal serum potassium or sodium level * Has a history of active or unstable cardio/cerebro-vascular disease, including thromboembolic events * Has a history of seizure within 6 months of providing documented informed consent or any condition that may predispose to seizures within 12 months before the date of randomization * Has a history of clinically significant ventricular arrhythmias * Has received an anticancer monoclonal antibody (mAb) within 4 weeks before the date of randomization, or has not recovered from adverse events (AEs) due to mAbs administered more than 4 weeks before the date of randomization * Has undergone major surgery, including local prostate intervention (except prostate biopsy), within 28 days before the date of randomization, and has not recovered from the toxicities and/or complications * Participants who have not adequately recovered from major surgery or have ongoing surgical complications * Has used herbal or medicinal products that may have hormonal anti-prostate cancer activity and/or are known to decrease prostate-specific Antigen (PSA) (eg, saw palmetto, megesterol acetate, citrus pectin polysaccharide) within 4 weeks before the date of randomization * Has received radium-223 or Lutetium-177 within 4 weeks before the date of randomization, or has not recovered to Grade ≤1 or baseline from AEs due to radium-223 or Lutetium-177 administered more than 4 weeks before the date of randomization * Has received treatment with 5-αreductase inhibitors (eg, finasteride or dutasteride), estrogens, or cyproterone within 4 weeks before the date of randomization * Has received colony-stimulating factors within 28 days before the date of randomization * Has received a whole blood transfusion in the last 120 days before the date of randomization. Packed red blood cells and platelet transfusions are acceptable if not given within 28 days of the date of randomization * Has received prior targeted small molecule therapy or NHA treatment within 4 weeks before the first dose of study intervention as follows: enzalutamide or apalutamide within 3 weeks or abiraterone acetate + prednisone or darolutamide within 2 weeks * Has a "superscan" bone scan * Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior the first dose of study medication * Has a known additional malignancy that is progressing or has required active treatment within the past 3 years * Has known active central nervous system (CNS) metastases and/or carcinomatous meningitis * Has an active autoimmune disease that has required systemic treatment in past 2 years * Has an active infection requiring systemic therapy * Has concurrent active HBV or known active HCV infection * Has a history of long QTc syndrome * Has any of the following at Screening Visit: hypotension (systolic BP \<110 mm Hg) or uncontrolled hypertension (systolic BP ≥160 mm Hg or diastolic BP ≥90 mm Hg, in 2 out of 3 recordings with optimized antihypertensive therapy) * Is unable to swallow capsules/tablets * Is currently being treated with cytochrome 450-inducing antiepileptic drugs for seizures * Participants on an unstable dose of thyroid hormone therapy within 6 months before the start of the study intervention * Received prior systemic anticancer therapy including investigational agents within 4 weeks before the first dose of study intervention * Received prior radiotherapy within 2 weeks of start of study intervention, or radiation-related toxicities, requiring corticosteroids * Received a live or live-attenuated vaccine within 30 days before the first dose of study intervention * Systemic use of the following medications within 2 weeks before the first dose of study intervention: strong CYP3A4 inducers (eg, avasimibe, carbamazepine, lumacaftor, phenobarbital, rifampicin, rifapentine, or St John's Wort); P-gp inhibitors (eg, erythromycin, clarithromycin, rifampicin, ketoconazole, itraconazole, posaconazole, artesunate-pyronaridine, ritonavir, indinavir, nelfinavir, atazanavir, glecaprevir-pibrentasvir, simeprevir, ledipasvir-sofosbuvir, verapamil, diltiazem, dronedarone, propafenone, quinidine, cyclosporine, valspodar, or milk thistle \[Silybum marianum\]) * Use of aldosterone antagonist (eg, spironolactone, eplerenone) and phenytoin within 4 weeks before the start of the study intervention
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Metastatic castration resistant prostate cancer are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The study's own enquiry address
This study publishes an address for enquiries. See it below .
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The places running it
237 sites in 34 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
Genom att skicka in godkänner du våra Användarvillkor
Study contacts
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Contact
Email: •••••@•••••
Locations
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A. C. Camargo Cancer Center ( Site 0310)
ACTIVE_NOT_RECRUITINGSão Paulo, São Paulo, 01509-010, Brazil
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AHN Allegheny General Hospital ( Site 0001)
COMPLETEDPittsburgh, Pennsylvania, 15212, United States
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Ad-Vance Medical Research-Research ( Site 1353)
ACTIVE_NOT_RECRUITINGPonce, 00717, Puerto Rico
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Addenbrooke's Hospital ( Site 1605)
RECRUITINGCambridge, Cambridgeshire, CB2 2QQ, United Kingdom
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Affiliated hospital of Jiangnan university ( Site 0434)
RECRUITINGWuxi, Jiangsu, 214122, China
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Akademiska sjukhuset-Blod- och tumörsjukdomar ( Site 1477)
RECRUITINGUppsala, Uppsala County, 751 85, Sweden
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Akershus Universitetssykehus-Onkologisk avdeling ( Site 1227)
RECRUITINGLørenskog, Akershus, 1474, Norway
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Akita University Hospital ( Site 0904)
RECRUITINGAkita, 010-8543, Japan
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Aliada-Oncologìa ( Site 1257)
ACTIVE_NOT_RECRUITINGLima, 15036, Peru
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Amsterdam UMC, locatie VUmc ( Site 1156)
COMPLETEDAmsterdam, North Holland, 1081 HV, Netherlands
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Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 1552)
RECRUITINGAnkara, 06800, Turkey (Türkiye)
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Anschutz Cancer Pavilion ( Site 0046)
RECRUITINGAurora, Colorado, 80045, United States
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Asahikawa Medical University Hospital ( Site 0901)
RECRUITINGAsahikawa, Hokkaido, 078-8510, Japan
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Asan Medical Center-Oncology ( Site 1402)
RECRUITINGSongpagu, Seoul, 05505, South Korea
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Asociación de Beneficencia Hospital Sirio Libanés ( Site 0205)
RECRUITINGBuenos Aires, Buenos Aires F.D., C1419AHN, Argentina
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Atlantic Health System Morristown Medical Center ( Site 0115)
RECRUITINGMorristown, New Jersey, 07960, United States
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Avera Cancer Institute - Aberdeen ( Site 0123)
RECRUITINGAberdeen, South Dakota, 57401, United States
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Avera Cancer Institute - Marshall ( Site 0122)
RECRUITINGMarshall, Minnesota, 56258, United States
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Avera Cancer Institute - Mitchell ( Site 0121)
RECRUITINGMitchell, South Dakota, 57301, United States
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Avera Cancer Institute - Pierre ( Site 0118)
RECRUITINGPierre, South Dakota, 57501, United States
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Avera Cancer Institute - Yankton ( Site 0117)
RECRUITINGYankton, South Dakota, 57078, United States
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Avera Cancer Institute- Research ( Site 0094)
RECRUITINGSioux Falls, South Dakota, 57105, United States
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Bacs-Kiskun Varmegyei Oktatokorhaz-Onkoradiologiai Kozpont ( Site 0752)
RECRUITINGKecskemét, Bács-Kiskun county, 6000, Hungary
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Baltimore Veterans Affairs Medical Center ( Site 0069)
RECRUITINGBaltimore, Maryland, 21201, United States
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Baskent University Dr. Turgut Noyan Research and Training Center-ONCOLOGY ( Site 1554)
RECRUITINGAdana, 01250, Turkey (Türkiye)
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Beijing Cancer hospital-Urinary Surgery ( Site 0395)
RECRUITINGBeijing, Beijing Municipality, 100142, China
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Beijing Friendship Hospital Affiliate of Capital University ( Site 0396)
RECRUITINGBeijing, Beijing Municipality, 100050, China
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Bell Land General Hospital ( Site 0913)
RECRUITINGSakai, Osaka, 599-8247, Japan
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Blue Ridge Cancer Care ( Site 0004)
RECRUITINGRoanoke, Virginia, 24014, United States
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Bradford Hill Norte ( Site 0357)
RECRUITINGAntofagasta, 1240000, Chile
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Bradfordhill-Clinical Area ( Site 0351)
RECRUITINGSantiago, Region M. de Santiago, 8420383, Chile
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Bruce W. Carter Veterans Affairs Medical Center ( Site 0082)
COMPLETEDMiami, Florida, 33125, United States
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CIO - Centro de Inmuno-Oncología de Occidente ( Site 1103)
RECRUITINGGuadalajara, Jalisco, 44630, Mexico
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Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer ( Site 0632)
RECRUITINGRennes, Ille-et-Vilaine, 35042, France
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Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire ( Site 0630)
RECRUITINGNîmes, Gard, 30029, France
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Centre Hospitalier de l'Université de Montréal ( Site 0326)
ACTIVE_NOT_RECRUITINGMontreal, Quebec, H2X 3E4, Canada
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Centre Hospitalier de la Cote Basque ( Site 0633)
RECRUITINGBayonne, Pyrenees-Atlantiques, 64109, France
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Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre ( Site 0328)
RECRUITINGGreenfield Park, Quebec, J4V 2H1, Canada
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Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne ( Site 0629)
RECRUITINGClermont-Ferrand, Puy-de-Dome, 63003, France
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Centre Oscar Lambret ( Site 0634)
RECRUITINGLille, Ain, 59020, France
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Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0327)
RECRUITINGQuébec, Quebec, G1J 1Z4, Canada
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Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer ( Site 0329)
ACTIVE_NOT_RECRUITINGSherbrooke, Quebec, J1H 5H4, Canada
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Centro de Investigacion Clinica de Oaxaca ( Site 1109)
RECRUITINGMexico City, Mexico City, 68020, Mexico
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Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 1302)
RECRUITINGBydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-796, Poland
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Chang Gung Medical Foundation-Linkou Branch-Medical Oncology ( Site 1504)
RECRUITINGTaoyuan, 333, Taiwan
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Charing Cross Hospital-Oncology Research ( Site 1606)
RECRUITINGLondon, Hammersmith and Fulham, W6 8RF, United Kingdom
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Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 0679)
RECRUITINGBerlin, 10117, Germany
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China Medical University Hospital-Department of Urology ( Site 1503)
RECRUITINGTaichung, 40447, Taiwan
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Chongqing Three Gorges Central Hospital's ( Site 0426)
RECRUITINGChongqing, Chongqing Municipality, 404100, China
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Chongqing University Cancer Hospital ( Site 0416)
RECRUITINGChongqing, Chongqing Municipality, 400030, China
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Chulalongkorn University ( Site 1530)
RECRUITINGBangkok, Bangkok, 10330, Thailand
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Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia-Center Investigator ( Site 0501)
RECRUITINGBogotá, Bogota D.C., 111321, Colombia
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Clinica Universidad Catolica del Maule-Oncology ( Site 0355)
RECRUITINGTalca, Maule Region, 3465584, Chile
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Clinical Research Chile SpA ( Site 0358)
ACTIVE_NOT_RECRUITINGValdivia, Los Ríos Region, 5110683, Chile
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Clínica Imbanaco S.A.S ( Site 0509)
COMPLETEDCali, Valle del Cauca Department, 760042, Colombia
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Clínica Sánchez Ferrer ( Site 1261)
RECRUITINGTrujillo, La Libertad, 13009, Peru
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Clínica de Neoplasias Litoral ( Site 0305)
RECRUITINGItajaí, Santa Catarina, 88301-220, Brazil
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Colorado Clinical Research ( Site 0067)
COMPLETEDLakewood, Colorado, 80228, United States
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Complexo Hospitalario Universitario de Ourense ( Site 1426)
RECRUITINGOurense, Orense, 32005, Spain
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Comprehensive Cancer Centers of Nevada ( Site 0010)
RECRUITINGLas Vegas, Nevada, 89148, United States
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Cross Cancer Institute ( Site 0332)
RECRUITINGEdmonton, Alberta, T6G 1Z2, Canada
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Debreceni Egyetem Klinikai Kozpont-Onkológiai Klinika ( Site 0758)
RECRUITINGDebrecen, 4032, Hungary
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Dubbo Hospital ( Site 0235)
RECRUITINGDubbo, New South Wales, 2830, Australia
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Dunedin Hospital-Southern Blood and Cancers Service ( Site 1203)
RECRUITINGDunedin, Otago, 9016, New Zealand
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ETZ Elisabeth-Internal Medicine ( Site 1160)
RECRUITINGTilburg, North Brabant, 5022 GC, Netherlands
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Ehime University Hospital ( Site 0918)
RECRUITINGTōon, Ehime, 791-0295, Japan
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Emek Medical Center ( Site 0830)
RECRUITINGAfula, 1834111, Israel
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FALP ( Site 0353)
ACTIVE_NOT_RECRUITINGSantiago, Region M. de Santiago, 7500921, Chile
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Faculty of Medicine - Khon Kaen University ( Site 1526)
RECRUITINGMuang, Changwat Khon Kaen, 40002, Thailand
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Faculty of Medicine Siriraj Hospital ( Site 1531)
RECRUITINGBangkoknoi, Bangkok, 10700, Thailand
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Fakultni nemocnice Olomouc-Onkologicka klinika ( Site 0555)
RECRUITINGOlomouc, Olomouc Region, 779 00, Czechia
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Fakultni nemocnice Ostrava-Klinika onkologicka ( Site 0554)
RECRUITINGOstrava, Moravian-Silesian Region, 708 52, Czechia
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Fakultni nemocnice v Motole-Onkologicka klinika 2. LF UK a FN Motol ( Site 0551)
RECRUITINGPrague, Praha 5, 150 06, Czechia
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Filios Alta Medicina ( Site 1106)
RECRUITINGMonterrey, Nuevo León, 64460, Mexico
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First Huai'an Hospital Affiliated to Nanjing Medical University ( Site 0436)
RECRUITINGHuaian, Jiangsu, 223300, China
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Florida Cancer Specialists - South ( Site 7003)
COMPLETEDFort Myers, Florida, 33901, United States
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Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 0877)
RECRUITINGMilan, Lombardy, 20133, Italy
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Franciscus Gasthuis & Vlietland, Locatie Vlietland ( Site 1151)
RECRUITINGSchiedam, South Holland, 3118 JH, Netherlands
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Fred Hutchinson Cancer Center ( Site 0013)
RECRUITINGSeattle, Washington, 98109, United States
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Fudan University Shanghai Cancer Center-Urology department ( Site 0376)
RECRUITINGShanghai, Shanghai Municipality, 200000, China
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Fukushima Medical University Hospital ( Site 0933)
RECRUITINGFukushima, 960-1295, Japan
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Fundacion Centro Oncologico de Integración Regional-Medical Oncology ( Site 0204)
RECRUITINGMendoza, M5500AYB, Argentina
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Fundación Cardiovascular de Colombia ( Site 0503)
RECRUITINGPiedecuesta, Santander Department, 681017, Colombia
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Fundación Instituto Valenciano de Oncología-Oncologico ( Site 1430)
RECRUITINGValencia, Valenciana, Comunitat, 46009, Spain
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Fundación Valle del Lili ( Site 0505)
RECRUITINGCali, Valle del Cauca Department, 760032, Colombia
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Gifu University Hospital ( Site 0910)
RECRUITINGGifu, 501-1112, Japan
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Greenebaum Comprehensive Cancer Center ( Site 0049)
RECRUITINGBaltimore, Maryland, 21201, United States
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Gulhane Egitim Arastirma Hastanesi ( Site 1558)
RECRUITINGAnkara, 06010, Turkey (Türkiye)
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Gustave Roussy ( Site 0626)
RECRUITINGVillejuif, Val-de-Marne, 94800, France
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HELIOS Kliniken Schwerin ( Site 0694)
RECRUITINGSchwerin, Mecklenburg-Vorpommern, 19055, Germany
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HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO-Medical Oncology ( Site 1428)
RECRUITINGSeville, 41013, Spain
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Hacettepe Universite Hastaneleri-oncology hospital ( Site 1551)
RECRUITINGAnkara, 06230, Turkey (Türkiye)
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Hadassah Medical Center ( Site 0833)
RECRUITINGJerusalem, 9112001, Israel
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Haga Ziekenhuis locatie Leyweg-Oncology ( Site 1164)
RECRUITINGThe Hague, South Holland, 2545 AA, Netherlands
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Hattiesburg Clinic Hematology/Oncology ( Site 0120)
RECRUITINGHattiesburg, Mississippi, 39401, United States
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Henry Ford Hospital ( Site 0015)
COMPLETEDDetroit, Michigan, 48202, United States
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Hiroshima University Hospital ( Site 0916)
RECRUITINGHiroshima, 734-8551, Japan
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Hokkaido University Hospital ( Site 0931)
RECRUITINGSapporo, Hokkaido, 060-8648, Japan
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Hopitaux Universitaires de Strasbourg ( Site 0627)
RECRUITINGStrasbourg, Bas-Rhin, 67200, France
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Hospital Aleman-Oncology ( Site 0207)
ACTIVE_NOT_RECRUITINGBuenos Aires, C1118AAT, Argentina
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Hospital Británico de Buenos Aires-Oncology ( Site 0202)
ACTIVE_NOT_RECRUITINGCiudad Autónoma de Buenos Aires, Buenos Aires, C1280AEB, Argentina
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Hospital Felicio Rocho ( Site 0317)
RECRUITINGBelo Horizonte, Minas Gerais, 30110-934, Brazil
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Hospital Jerez de la Frontera ( Site 1427)
RECRUITINGJerez de la Frontera, Cadiz, 11407, Spain
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Hospital Kuala Lumpur-Radiotherapy and Oncology ( Site 1078)
RECRUITINGKuala Lumpur, 50586, Malaysia
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Hospital Lucus Augusti-Oncology ( Site 1432)
RECRUITINGLugo, 27003, Spain
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Hospital Mario Penna ( Site 0309)
RECRUITINGBelo Horizonte, Minas Gerais, 30380-472, Brazil
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Hospital Santa Rita de Cassia-Centro de Pesquisa Clínica ( Site 0320)
RECRUITINGVitória, Espírito Santo, 29041-295, Brazil
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Hospital Sultan Ismail ( Site 1081)
RECRUITINGJohor Bahru, Johor, 81100, Malaysia
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Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Servicio de Oncología ( Site 1107)
RECRUITINGMonterrey, Nuevo León, 64460, Mexico
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Hospital Universitario 12 de Octubre-Medical Oncology ( Site 1433)
RECRUITINGMadrid, Madrid, Comunidad de, 28041, Spain
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Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 1431)
RECRUITINGMadrid, Madrid, Comunidad de, 28034, Spain
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Hospital Universitário Evangélico Mackenzie-Centro de Oncologia Mackenzie ( Site 0314)
RECRUITINGCuritiba, Paraná, 80440-220, Brazil
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Hospital Universitário São Francisco de Assis - Bragança Paulista ( Site 0308)
RECRUITINGBragança Paulista, São Paulo, 12916-542, Brazil
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Hospital of the University of Occupational and Environmental Health, Japan ( Site 0921)
COMPLETEDKitakyushu, Fukuoka, 807-8556, Japan
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Huadong Hospital Affiliated to Fudan University-Urology ( Site 0388)
RECRUITINGShanghai, Shanghai Municipality, 200041, China
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Hubei Cancer Hospital-Urinary surgery ( Site 0406)
RECRUITINGWuhan, Hubei, 430079, China
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Hunan Cancer Hospital ( Site 0405)
RECRUITINGChangsha, Hunan, 410013, China
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Hôpital Européen Georges Pompidou ( Site 0628)
ACTIVE_NOT_RECRUITINGParis, 75015, France
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IC La Serena Research ( Site 0356)
ACTIVE_NOT_RECRUITINGLa Serena, Coquimbo Region, 1720430, Chile
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IMAT S.A.S ( Site 0504)
RECRUITINGMontería, Departamento de Córdoba, 230002, Colombia
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INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS-Medical Oncology ( Site 1256)
RECRUITINGLima, 15038, Peru
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IPOR Instituto Peruano de Oncología & Radioterapia-Centro de Investigación ( Site 1254)
ACTIVE_NOT_RECRUITINGLima, 15036, Peru
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IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"-Oncologia Medica ( Site 0879)
RECRUITINGMeldola, Emilia-Romagna, 47014, Italy
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Instituto Alexander Fleming-Alexander Fleming ( Site 0206)
RECRUITINGBuenos Aires, Buenos Aires F.D., C1426ANZ, Argentina
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Instituto Regional de Enfermedades Neoplasicas del Centro (IREN CENTRO) ( Site 1258)
RECRUITINGConcepción, Departamento de Junín, 12125, Peru
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Instituto de Investigaciones Clínicas Mar del Plata ( Site 0201)
ACTIVE_NOT_RECRUITINGMar del Plata, Buenos Aires, B7600FZO, Argentina
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Istanbul Universitesi Cerrahpasa-Medical Oncology ( Site 1555)
RECRUITINGIstanbul, 34668, Turkey (Türkiye)
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James J. Peters VA Medical Center ( Site 0088)
RECRUITINGThe Bronx, New York, 10468, United States
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Jiangxi Cancer Hospital ( Site 0386)
RECRUITINGNanchang, Jiangxi, 330029, China
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Kagawa University Hospital ( Site 0917)
RECRUITINGKita, Kagawa-ken, 761-0701, Japan
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Kagoshima University Hospital ( Site 0929)
RECRUITINGKagoshima, 890-8520, Japan
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Kaiser Permanente Riverside Medical Center ( Site 0099)
RECRUITINGRiverside, California, 92505, United States
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Kanazawa Medical University Hospital ( Site 0909)
RECRUITINGMukai-awagasaki, Ishikawa-ken, 920-0265, Japan
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Kansai Medical University Hospital ( Site 0912)
RECRUITINGHirakata, Osaka, 573-1191, Japan
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Karolinska Universitetssjukhuset Solna ( Site 1478)
ACTIVE_NOT_RECRUITINGStockholm, Stockholm County, 171 64, Sweden
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Klinikum Wels-Grieskirchen GmbH ( Site 0279)
RECRUITINGWels, Upper Austria, 4600, Austria
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Kobe University Hospital ( Site 0914)
RECRUITINGKobe, Hyōgo, 650-0017, Japan
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Koc Universitesi Hastanesi ( Site 1561)
RECRUITINGIstanbul, 34010, Turkey (Türkiye)
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Kuopion Yliopistollinen Sairaala ( Site 0603)
ACTIVE_NOT_RECRUITINGKuopio, Northern Savonia, 70200, Finland
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Kurume University Hospital ( Site 0920)
RECRUITINGKurume, Fukuoka, 830-0011, Japan
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Kyushu University Hospital ( Site 0919)
RECRUITINGFukuoka, 812-8582, Japan
-
M Health Fairview Clinics and Surgery Center ( Site 0019)
RECRUITINGMinneapolis, Minnesota, 55455, United States
-
Macquarie University-MQ Health Clinical Trials Unit ( Site 0234)
RECRUITINGMacquarie University, New South Wales, 2109, Australia
-
Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 0553)
RECRUITINGBrno, Brno-mesto, 656 53, Czechia
-
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 1310)
RECRUITINGSiedlce, Masovian Voivodeship, 08-110, Poland
-
Meander Medisch Centrum ( Site 1157)
RECRUITINGAmersfoort, Utrecht, 3813 TZ, Netherlands
-
Medical Care and Research SA de CV ( Site 1108)
COMPLETEDMérida, Yucatán, 97070, Mexico
-
Medical College of Wisconsin ( Site 0020)
RECRUITINGMilwaukee, Wisconsin, 53226, United States
-
Medische Centrum Leeuwarden ( Site 1172)
ACTIVE_NOT_RECRUITINGLeeuwarden, Provincie Friesland, 8934 AD, Netherlands
-
Medizinische Universität Graz-Innere Medizin Klin. Abt. Onkologie ( Site 0280)
RECRUITINGGraz, Styria, 8036, Austria
-
Meir Medical Center. ( Site 0832)
RECRUITINGKfar Saba, 4428164, Israel
-
Memorial Ankara Hastanesi-Medical Oncology ( Site 1557)
RECRUITINGAnkara, 06520, Turkey (Türkiye)
-
Metro-Minnesota Community Clinical Oncology ( Site 0014)
ACTIVE_NOT_RECRUITINGSaint Louis Park, Minnesota, 55416, United States
-
Miyazaki Prefectural Miyazaki Hospital ( Site 0927)
RECRUITINGMiyazaki, 880-8510, Japan
-
Nagano Municipal Hospital ( Site 0932)
RECRUITINGNagano, 381-8551, Japan
-
Nanbu Tokushukai Hospital ( Site 0930)
RECRUITINGShimajiri, Okinawa, 901-0417, Japan
-
Nanchong Central Hospital-urology ( Site 0422)
RECRUITINGNanchong, Sichuan, 500643, China
-
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Urology ( Site 0377)
RECRUITINGNanjing, Jiangsu, 210008, China
-
Nara Medical University Hospital ( Site 0915)
COMPLETEDKashihara, Nara, 634-8522, Japan
-
National Cancer Centre Singapore ( Site 1377)
RECRUITINGSingapore, Central Singapore, 168583, Singapore
-
National Cancer Institute ( Site 1079)
RECRUITINGPutrajaya, Putrajaya, 62250, Malaysia
-
National Cheng Kung University Hospital-Urology ( Site 1502)
RECRUITINGTainan, 704, Taiwan
-
National Hospital Organization Kumamoto Medical Center ( Site 0924)
RECRUITINGKumamoto, 860-0008, Japan
-
National Hospital Organization Nagasaki Medical Center ( Site 0923)
RECRUITINGŌmura, Nagasaki, 856-8562, Japan
-
National Hospital Organization Oita Medical Center ( Site 0925)
RECRUITINGŌita, 870-0263, Japan
-
National Taiwan University Hospital-Urology ( Site 1506)
RECRUITINGTaipei, 10002, Taiwan
-
National University Hospital ( Site 1376)
RECRUITINGSingapore, Central Singapore, 119074, Singapore
-
Nederlands Kanker Instituut - Antoni van Leeuwenhoek - NKI-AVL ( Site 1153)
RECRUITINGAmsterdam, North Holland, 1066 CX, Netherlands
-
Nograd Varmegyei Szent Lazar Korhaz-Onkologia es Sugarterapias Osztaly ( Site 0761)
RECRUITINGSalgótarján, Nógrád megye, 3100, Hungary
-
Obras Sociais Irma Dulce ( Site 0302)
RECRUITINGSalvador, Estado de Bahia, 41680-430, Brazil
-
Ochsner Clinic Foundation ( Site 0108)
COMPLETEDNew Orleans, Louisiana, 70121, United States
-
Odense Universitetshospital-Department of oncology ( Site 0579)
ACTIVE_NOT_RECRUITINGOdense, Region Syddanmark, 5000, Denmark
-
Oncosalud-Clinical Research ( Site 1260)
ACTIVE_NOT_RECRUITINGLima, 15036, Peru
-
Ordensklinikum Linz GmbH Elisabethinen-Urologie ( Site 0276)
RECRUITINGLinz, Upper Austria, 4020, Austria
-
Oregon Health and Science University ( Site 0028)
COMPLETEDPortland, Oregon, 97239, United States
-
Országos Onkológiai Intézet-Urogenitális Tumorok és Klinikai Farmakológiai Osztály ( Site 0756)
RECRUITINGBudapest, Pest County, 1122, Hungary
-
Ospedale San Raffaele-Oncologia Medica ( Site 0876)
RECRUITINGMilan, 20132, Italy
-
Pan American Center for Oncology Trials - Ciudadela ( Site 1351)
COMPLETEDSan Juan, 00909, Puerto Rico
-
Peking University First Hospital-Urology ( Site 0390)
RECRUITINGBeijing, Beijing Municipality, 100034, China
-
Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 0230)
RECRUITINGMelbourne, Victoria, 3000, Australia
-
Pontificia Universidad Catolica de Chile-Hemato-Oncology ( Site 0354)
RECRUITINGSantiago, Region M. de Santiago, 8330024, Chile
-
Prince of Wales Hospital ( Site 0730)
ACTIVE_NOT_RECRUITINGShatin, Hong Kong
-
Princess Alexandra Hospital-Cancer Care Serices ( Site 0237)
RECRUITINGBrisbane, Queensland, 4102, Australia
-
Princess Margaret Cancer Centre ( Site 0330)
RECRUITINGToronto, Ontario, M5G 2M9, Canada
-
Puerto Rico Medical Research Center LLC ( Site 1354)
COMPLETEDHato Rey, 00917, Puerto Rico
-
Queen Mary Hospital ( Site 0727)
ACTIVE_NOT_RECRUITINGHong Kong, Hong Kong
-
Quemex Medical and Research ( Site 1112)
RECRUITINGMexico City, Mexico City, 14308, Mexico
-
Rabin Medical Center ( Site 0828)
RECRUITINGPetah Tikva, 4941492, Israel
-
Radboudumc-Medical Oncology ( Site 1152)
RECRUITINGNijmegen, Gelderland, 6525 GA, Netherlands
-
Ralph H. Johnson VA Health Care System (RHJVAHCS)-Urology ( Site 0083)
COMPLETEDCharleston, South Carolina, 29401, United States
-
Rambam Health Care Campus-Oncology Division ( Site 0826)
RECRUITINGHaifa, 3109601, Israel
-
Regionalny Szpital Specjalistyczny im. dr. Władyslawa Biegańskiego ( Site 1316)
COMPLETEDGrudziądz, Kuyavian-Pomeranian Voivodeship, 86-300, Poland
-
Rigshospitalet ( Site 0576)
RECRUITINGCopenhagen, Capital Region, 2100, Denmark
-
Rutgers Cancer Institute of New Jersey ( Site 0033)
COMPLETEDNew Brunswick, New Jersey, 08903, United States
-
SCRI Oncology Partners ( Site 7000)
RECRUITINGNashville, Tennessee, 37203, United States
-
Saga-Ken Medical Centre Koseikan ( Site 0922)
RECRUITINGSaga, Saga-ken, 840-8571, Japan
-
Sahlgrenska Universitetssjukhuset ( Site 1479)
RECRUITINGGothenburg, Västra Götaland County, 413 45, Sweden
-
Samsun Medical Park Hastanesi-medical oncology ( Site 1560)
RECRUITINGSamsun, 55200, Turkey (Türkiye)
-
Samsung Medical Center ( Site 1405)
RECRUITINGSeoul, 06351, South Korea
-
Sanatorio Parque ( Site 0208)
RECRUITINGRosario, Santa Fe Province, S2000DSV, Argentina
-
Sapporo Medical University Hospital ( Site 0902)
RECRUITINGSapporo, Hokkaido, 060-8543, Japan
-
Sarawak General Hospital-Radiotherapy Unit ( Site 1076)
RECRUITINGKuching, Sarawak, 93586, Malaysia
-
Second Affiliated hospital of Anhui Medical University-Urology ( Site 0408)
RECRUITINGHefei, Anhui, 230000, China
-
Seoul National University Hospital-Oncology ( Site 1401)
RECRUITINGSeoul, 03080, South Korea
-
Severance Hospital, Yonsei University Health System-Medical oncology ( Site 1404)
RECRUITINGSeoul, 03722, South Korea
-
Sheba Medical Center ( Site 0827)
RECRUITINGRamat Gan, 5265601, Israel
-
Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0502)
RECRUITINGValledupar, Cesar Department, 200001, Colombia
-
Songklanagarind hospital ( Site 1527)
RECRUITINGHat Yai, Changwat Songkhla, 90110, Thailand
-
Southwest Hospital of Third Military Medical University ( Site 0420)
RECRUITINGChongqing, Chongqing Municipality, 400038, China
-
Spaarne Gasthuis - Hoofddorp-Oncology ( Site 1170)
ACTIVE_NOT_RECRUITINGHoofddorp, North Holland, 2134 TM, Netherlands
-
St. Olavs Hospital-Kreftklinikken ( Site 1231)
ACTIVE_NOT_RECRUITINGTrondheim, Sor-Trondelag, 7030, Norway
-
St. Vincent's University Hospital ( Site 0802)
RECRUITINGDublin, Dublin, D04 T6F4, Ireland
-
Stanford Cancer Center ( Site 0036)
RECRUITINGPalo Alto, California, 94304, United States
-
Suining Central Hospital ( Site 0437)
RECRUITINGSuining, Sichuan, 629000, China
-
Sun Yat-sen University Cancer Center-Internal medicine ( Site 0413)
RECRUITINGGuangzhou, Guangdong, 511400, China
-
Sunnybrook Research Institute ( Site 0331)
RECRUITINGToronto, Ontario, M4N 3M5, Canada
-
Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zakl-Klinika Onkologii Klinicznej, Dzial Ch ( Site 1318)
RECRUITINGKielce, Świętokrzyskie Voivodeship, 25-734, Poland
-
Sykehuset Østfold Kalnes ( Site 1228)
COMPLETEDSarpsborg, Østfold fylke, 1714, Norway
-
Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie-Oddzial Dzienny Chemioterapii ( Site 1303)
RECRUITINGKoszalin, West Pomeranian Voivodeship, 75-581, Poland
-
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 1553)
RECRUITINGIstanbul, 34722, Turkey (Türkiye)
-
Taipei Veterans General Hospital ( Site 1505)
RECRUITINGTaipei, 112, Taiwan
-
Tallaght University Hospital ( Site 0801)
RECRUITINGDublin, D24 NR0A, Ireland
-
Tampereen yliopistollinen sairaala ( Site 0604)
RECRUITINGTampere, Pirkanmaa, 33520, Finland
-
Tan Tock Seng Hospital-Medical Oncology ( Site 1378)
RECRUITINGSingapore, Central Singapore, 308433, Singapore
-
Tauranga Hospital-Bay of Plenty Clinical Trials Unit ( Site 1201)
RECRUITINGTauranga, Bay of Plenty, 3112, New Zealand
-
Texas Oncology - Central/South Texas ( Site 8003)
RECRUITINGAustin, Texas, 78731, United States
-
Texas Oncology - DFW ( Site 8001)
COMPLETEDDallas, Texas, 75246, United States
-
Texas Oncology - Gulf Coast ( Site 8002)
RECRUITINGHouston, Texas, 77024, United States
-
The Beatson West of Scotland Cancer Centre ( Site 1603)
RECRUITINGGlasgow, Glasgow City, G12 0YN, United Kingdom
-
The Christie NHS Foundation Trust ( Site 1608)
RECRUITINGManchester, m20 4bx, United Kingdom
-
The First Affiliated Hospital Of Fujian Medical University-Urology ( Site 0414)
RECRUITINGFuzhou, Fujian, 350005, China
-
The First Affiliated Hospital of Chongqing Medical University ( Site 0427)
RECRUITINGChongqing, Chongqing Municipality, 400010, China
-
The First Affiliated Hospital of Guangzhou Medical University ( Site 0412)
RECRUITINGGuangzhou, Guangdong, 510230, China
-
The First Affiliated Hospital of Ningbo University ( Site 0383)
RECRUITINGNingbo, Zhejiang, 315010, China
-
The First Affiliated Hospital of Wenzhou Medical University-Urology Surgery ( Site 0379)
RECRUITINGWenzhou, Zhejiang, 325000, China
-
The First Affiliated Hospital of Xi'an Jiaotong University-Oncology ( Site 0393)
RECRUITINGXi'an, Shaanxi, 710061, China
-
The First Affiliated hospital of Xiamen University-Urology ( Site 0415)
RECRUITINGXiamen, Fujian, 361003, China
-
The First Hospital of Jiaxing-urology ( Site 0380)
RECRUITINGJiaxing, Zhejiang, 314001, China
-
The Jikei University Hospital ( Site 0907)
COMPLETEDMinato, Tokyo, 105-8471, Japan
-
The Ottawa Hospital - General Campus-The Ottawa Hospital Cancer Centre ( Site 0336)
RECRUITINGOttawa, Ontario, K1H 8L6, Canada
-
The Royal Cornwall Hospital ( Site 1610)
RECRUITINGTruro, England, TR1 3LJ, United Kingdom
-
The Second Affiliated Hospital Of Kunming Medical University ( Site 0429)
RECRUITINGKunming, Yunnan, 650033, China
-
The Second Affiliated Hospital of Xi'an Jiaotong University ( Site 0394)
RECRUITINGXi'an, Shaanxi, 710004, China
-
The Second Hospital of Tianjin Medical University ( Site 0391)
RECRUITINGTianjin, Tianjin Municipality, 300211, China
-
The Third People's Hospital of Chengdu (CDTPH) ( Site 0428)
RECRUITINGChengdu, Sichuan, 500643, China
-
The University of Osaka Hospital ( Site 0911)
RECRUITINGSuita, Osaka, 565-0871, Japan
-
Tianjin Medical University Cancer Institute & Hospital ( Site 0392)
RECRUITINGTianjin, Tianjin Municipality, 300060, China
-
Toho University Sakura Medical Center ( Site 0906)
RECRUITINGSakura, Chiba, 285-8741, Japan
-
Tongji Hospital Tongji Medical,Science & Technology ( Site 0407)
RECRUITINGWuhan, Hubei, 430000, China
-
Turku University Hospital-Department of Oncology ( Site 0601)
RECRUITINGTurku, Southwest Finland, 20520, Finland
-
Universitaetsklinikum Hamburg-Eppendorf-Onkologisches Zentrum ( Site 0705)
RECRUITINGHamburg, 20246, Germany
-
University College London Hospital ( Site 1612)
RECRUITINGLondon, London, City of, NW1 2PG, United Kingdom
-
University Hospitals Cleveland Medical Center ( Site 0043)
RECRUITINGCleveland, Ohio, 44106, United States
-
University Malaya Medical Centre ( Site 1077)
COMPLETEDLembah Pantai, Kuala Lumpur, 59100, Malaysia
-
University Of Nebraska Medical Center-Oncology/Hematology ( Site 0095)
RECRUITINGOmaha, Nebraska, 68105, United States
-
University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 0040)
COMPLETEDOrange, California, 92868, United States
-
University of Chicago Medical Center ( Site 0045)
RECRUITINGChicago, Illinois, 60637, United States
-
University of Colorado Health - Highlands Ranch Hospital ( Site 0111)
RECRUITINGHighlands Ranch, Colorado, 80129, United States
-
University of Colorado Health - Lone Tree Medical Center ( Site 0112)
RECRUITINGLone Tree, Colorado, 80124, United States
-
University of Illinois at Chicago ( Site 0105)
RECRUITINGChicago, Illinois, 60612, United States
-
University of Iowa ( Site 0047)
COMPLETEDIowa City, Iowa, 52242, United States
-
University of Kentucky Chandler Medical Center ( Site 0048)
COMPLETEDLexington, Kentucky, 40536, United States
-
University of Miami Hospital and Clinics, Sylvester Cancer Center ( Site 0051)
RECRUITINGMiami, Florida, 33136, United States
-
University of Miyazaki Hospital ( Site 0926)
RECRUITINGMiyazaki, 889-1692, Japan
-
University of Virginia Health System ( Site 0054)
RECRUITINGCharlottesville, Virginia, 22908, United States
-
Universitätsklinikum Bonn-Klinik und Poliklinik für Urologie und Kinderurologie ( Site 0680)
RECRUITINGBonn, North Rhine-Westphalia, 53127, Germany
-
Universitätsklinikum Jena-Klinik und Poliklinik für Urologie ( Site 0682)
RECRUITINGJena, Thuringia, 07747, Germany
-
Universitätsklinikum Münster - Albert Schweitzer Campus-Klinik für Urologie ( Site 0678)
RECRUITINGMünster, North Rhine-Westphalia, 48149, Germany
-
Universitätsklinikum Schleswig-Holstein-Klinik für Urologie ( Site 0691)
RECRUITINGLübeck, Schleswig-Holstein, 23538, Germany
-
VA Portland Health Care System ( Site 0058)
RECRUITINGPortland, Oregon, 97239, United States
-
VCU Health Adult Outpatient Pavillion ( Site 0061)
COMPLETEDRichmond, Virginia, 23219, United States
-
Vejle Sygehus ( Site 0578)
RECRUITINGVejle, Region Syddanmark, 7100, Denmark
-
VieCuri Medisch Centrum ( Site 1173)
COMPLETEDVenlo, Limburg, 5912 BL, Netherlands
-
Washington University School of Medicine-Internal Medicine/Oncology ( Site 0062)
RECRUITINGSt Louis, Missouri, 63110, United States
-
West China Hospital, Sichuan University-Urology Surgery ( Site 0417)
RECRUITINGChengdu, Sichuan, 610041, China
-
Westmead Hospital ( Site 0232)
RECRUITINGWestmead, New South Wales, 2145, Australia
-
Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu ( Site 1304)
COMPLETEDTorun, Kuyavian-Pomeranian Voivodeship, 87-100, Poland
-
Xinjiang Medical University Cancer Hospital - Urumqi-Urology ( Site 0419)
RECRUITINGÜrümqi, Xinjiang, 830000, China
-
Yale-New Haven Hospital-Yale Cancer Center ( Site 0064)
RECRUITINGNew Haven, Connecticut, 06510, United States
-
Yantai Yuhuangding Hospital ( Site 0397)
RECRUITINGYantai, Shandong, 264099, China
-
Yokohama City University Medical Center ( Site 0908)
RECRUITINGYokohama, Kanagawa, 232-0024, Japan
-
Yunnan Province Cancer Hospital ( Site 0418)
RECRUITINGKunming, Yunnan, 650107, China
-
Zachodniopomorskie Centrum Onkologii ( Site 1311)
RECRUITINGSzczecin, West Pomeranian Voivodeship, 71-730, Poland
-
Zhejiang Cancer Hospital ( Site 0435)
RECRUITINGHangzhou, Zhejiang, 310022, China
-
Zhejiang Provincial People's Hospital-Urology ( Site 0378)
RECRUITINGHangzhou, Zhejiang, 310014, China
-
Zhongshan Hospital Fudan University ( Site 0430)
RECRUITINGShanghai, Shanghai Municipality, 200032, China
-
Zuyderland Medical Centre-Trialbureau Interne Geneeskunde ( Site 1163)
RECRUITINGSittard-Geleen, Limburg, 6162 BG, Netherlands
-
klinikum rechts der isar der technischen universität münchen-Urologische Klinik und Poliklinik ( Site 0696)
ACTIVE_NOT_RECRUITINGMunich, Bavaria, 81675, Germany
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