Can donor cartilage transplants stand the test of time? a lifelong registry aims to find out
NCT ID NCT02503228
First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time
Summary
This registry follows patients who receive donor cartilage or meniscus transplants for joint defects in the knee, hip, ankle, or shoulder. Researchers are collecting long-term data on pain, function, and whether the grafts need revision or fail over time. The goal is to understand how well these transplants hold up and what factors influence success.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- osteochondral and/or meniscal allograft transplantation
- What this could lead to
- If successful, this registry could provide long-term data on how well these grafts work and which patients benefit most.
- What could go wrong
- As an observational registry, it cannot prove cause and effect, and results may take many years to emerge.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 5,000 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2015
- Expected to finish
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Dec 2050
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients enrolled will be those that have undergone an OCA and or meniscal transplantation at University of Missouri Healthcare (Mizzou BioJoint Center) and consented to inclusion in the registry
- Ages
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13 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Adults and children age ≥13 years 2. Knee, hip, ankle, or shoulder osteochondral defect ≥15mm as determined by MRI or diagnostic knee arthroscopy for allograft transplantation 3. Must be physically and mentally willing and able to comply with postoperative and routinely scheduled clinical and radiographic evaluations. 4. Must be able to read and understand English or a language for which translated versions of the patient reported questionnaires and Informed consent form are available. 5. Must be able to sign informed consent and must voluntarily sign the Institutional Review Board (IRB)/Independent Ethics Committee (IEC)-approved subject Informed Consent Form. Exclusion Criteria: 1. Is a prisoner 2. Is receiving workman's compensation 3. Subject is mentally incompetent such that would preclude the subject from providing adequate consent and/or complying with study requirements
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of Missouri
Columbia, Missouri, 65212, United States