Milk mystery: which type causes fewer gut woes?
NCT ID NCT05305391
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study looked at how different types of milk—A2 milk and protein-hydrolysed lactose-free A1 milk—affect gut symptoms and inflammation in 37 adults who usually feel discomfort from regular milk. Participants drank each milk type for three days while taking either a lactase capsule or a placebo. The goal was to see if protein breakdown or lactose content makes milk easier to tolerate.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- milk (A2, protein-hydrolysed lactose-free A1) with lactase or placebo capsule
- What this could lead to
- If successful, this could help identify which milk components cause symptoms and inflammation, potentially guiding dietary choices for people with milk intolerance.
- What could go wrong
- This is a small, early-stage study with only 37 participants. Results may not apply to everyone with milk intolerance, and the findings are exploratory.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
37 people
The number who actually took part.
- Started
-
May 2022
- Finished
-
Mar 2023
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 65 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Perceive disturbing gut symptoms from regular milk * Commits to the research diet for the whole research period * Age: 18-65 * BMI: 18.5-30 * Healthy (normal kidney, liver and thyroid function and self-reported) Exclusion Criteria: * Milk allergy * Regular medication (other than contraceptives) or medication affecting the gut * Recent course of antibiotics (\< 3 months prior the study) * Pregnancy or lactation * Diagnosed bowel disease
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Milk intolerance are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Food Sciences, Department of Life Technologies, University of Turku
Turku, Turku, 20500, Finland
More trials for these conditions
Other studies related to the condition(s) this trial covers.