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Tiny bone holes could make Braces-Free teeth straightening faster

NCT ID NCT07169968

Symptom relief Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests whether making tiny holes in the jawbone (micro-osteoperforations) can speed up clear aligner treatment for crowded lower front teeth. Twenty adults aged 18 to 35 with mild to moderate crowding will be split into two groups: one gets aligners alone, the other gets aligners plus the bone holes. Researchers will compare how many aligners each group needs and measure pain, gum health, and crowding relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
micro-osteoperforations (tiny holes drilled in the jawbone)
What this could lead to
If it works, this could make clear aligner treatment faster and more efficient for people with crowded lower front teeth.
What could go wrong
This is a very small early trial with only 20 people, so results may not apply to everyone. The procedure involves drilling tiny holes in the bone, which could cause pain or swelling.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2024

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria 1. Adult patients with age ranging from 18 to 35 years. 2. Healthy periodontium. 3. Presence of full set of permanent dentition excluding third molars. 4. Patients requiring non-extraction orthodontic treatment in the mandibular arch. 5. Mandibular anterior little's irregularity index from 3 to 6. 6. No spaces in the mandibular arch. Exclusion Criteria: 1. Presence of retained primary teeth in the mandibular arch. 2. Patients having systemic diseases as (e.g., diabetes, osteoporosis) or taking medication that could affect tooth movement (e.g., bisphosphonates, anticancer drugs) 3. Vulnerable patients. 4. Smokers. 5. Pregnant female patients.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mandibular dental crowding

Contacts and locations

Locations

  • Department of orthodontics, Faculty of Dentistry, Ain Shams University

    Cairo, Abassia, 11566, Egypt