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Could a diabetes drug gel ease knee arthritis pain?

NCT ID NCT07395895

Symptom relief Sponsor: Badr University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether applying metformin gel through the skin with a mild electric current (iontophoresis) plus physical therapy can reduce pain and improve function in postmenopausal women with knee osteoarthritis. Sixty-eight women aged 50-70 will receive either the active gel or a placebo gel, alongside standard physical therapy. The trial is double-blind, meaning neither participants nor researchers know who gets the real treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
metformin gel
What this could lead to
If it works, this could offer a new, non-invasive way to reduce pain and improve mobility in postmenopausal women with knee osteoarthritis.
What could go wrong
This is a small, early-stage trial with only 68 participants. The treatment may not prove more effective than placebo, and results may not apply to men or younger women.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 68 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2026

An estimate. Start dates often move.

Expected to finish

May 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 70 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * • Postmenopausal women aged 50-70 years. * Clinical and radiographic diagnosis of knee osteoarthritis according to the American College of Rheumatology criteria. * Radiographic severity classified as Kellgren-Lawrence grade II or III. * Chronic knee pain for a duration of at least 3 months. * Pain intensity ≥4 on the Visual Analog Scale. * Ability to ambulate independently with or without assistive devices. * Ability to understand and follow instructions. * Willingness to participate and provide written informed consent. Exclusion Criteria: * • Severe knee osteoarthritis (Kellgren-Lawrence grade IV). * History of knee surgery or intra-articular injections within the previous 6 months. * Presence of inflammatory rheumatic diseases such as rheumatoid arthritis or gout. * Neurological disorders affecting lower limb function. * Uncontrolled metabolic, cardiovascular, or systemic diseases. * Current or recent use of metformin or other antidiabetic medications. * Skin lesions, infections, or hypersensitivity at the iontophoresis site. * Contraindications to electrotherapy such as pacemakers or implanted electronic devices. * Body mass index ≥35 kg/m². * Participation in another clinical trial within the last 3 months.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis in postmenopausal women

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Badr University in Cairo

    Cairo, 11829, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.