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Can a single bike ride improve artery function in metabolic syndrome?

NCT ID NCT07430839

Knowledge-focused Sponsor: University of Wisconsin, Madison Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether young adults with metabolic syndrome have poorer artery function in the neck, and if a 30-minute bike ride can temporarily improve it. Researchers will compare 48 participants with and without metabolic syndrome. The goal is to understand sex differences and the immediate benefits of exercise.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
exercise
What this could lead to
If successful, this could point toward exercise as a quick way to improve blood vessel health in young adults with metabolic syndrome.
What could go wrong
This is a small, early-stage study with only 48 participants, so results may not apply to everyone. The exercise effect may be temporary or not seen in all individuals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 48 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Young adult male and female participants with metabolic syndrome and age matched healthy male and female participants.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria (MetSyn cohort): * Waist circumference greater than 102 cm (males) or 82 cm (females) * Triglycerides over 150 mg/dL * HDL cholesterol less than 40 mg/dL (males) or 50 mg/dL (females) * Blood pressure ≥130/85 mmHg * Fasting plasma glucose over 110 mg/dL Inclusion Criteria (Healthy cohort): \- meet age criteria Exclusion Criteria: * Current smoker, defined as more than 5 cigarettes over past 30 days * Current diagnosis or history of: * peripheral vascular disease * hepatic disease * renal disease * lung disease * gastrointestinal disorders/bleeding * hematologic disease * stroke * myocardial infarction * coronary heart disease * congestive heart failure * heart surgery * sleep apnea * autoimmune diseases * traumatic brain injury, concussion, stroke, or seizures * Asthma * Polycystic ovarian syndrome * Type II diabetes * Currently pregnant or breastfeeding * Current musculoskeletal injury Medication use known to influence cardiovascular function, other than oral contraceptives * Hormonal contraceptive use, such as intrauterine device or hormonal implant use * Participants with ICAs unsuitable for imaging, as assessed during the screening visit via doppler ultrasonography Exclusion Criteria (healthy controls only): * BMI greater than 25 kg/m2 * Blood pressure over 125/80 mmHg * Meeting any MetSyn criteria listed for MetSyn cohort

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Conditions

The condition(s) this trial relates to.

abdominal obesity-metabolic syndrome metabolic syndrome X Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Metabolic syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Wisconsin

    RECRUITING

    Madison, Wisconsin, 53792, United States

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