New DNA vaccine shows promise against deadly MERS virus
NCT ID NCT04588428
First seen Jan 27, 2026 · Last updated Jun 23, 2026 · Updated 21 times
Summary
This Phase 2 trial tested a new DNA vaccine called INO-4700 in 192 healthy adults to see if it is safe and can trigger an immune response against MERS, a serious coronavirus. The vaccine is given as a shot under the skin followed by a quick electric pulse to help cells take up the DNA. The study looked at side effects and measured antibodies and T-cell responses.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Ahero Clincal Trials Unit
Kisumu, 40100, Kenya
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American University of Beirut Medical Center
Beirut, Lebanon
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Clinical Research Center, Irbid Specialty Hospital (CRC/ISH)
Irbid, 21110, Jordan
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Hammoud Hospital University Medical Center
Saida, Lebanon
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Kenya Medical Research Institute (KEMRI)/Walter Reed Project (WRP)
Kericho, 20200, Kenya
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Pharmaceutical Research Center / Jordan University of Science and Technology
Irbid, 22110, Jordan
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
INO-4700 (DNA vaccine given under the skin followed by a mild electric pulse to boost uptake)
What this could lead to
If successful, this could lead to a vaccine that protects people from MERS, a serious respiratory virus.
What could go wrong
This is a Phase 2 trial with only 192 healthy volunteers, so it is still early. The vaccine may not produce strong enough immunity or could cause side effects like injection site reactions.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.