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Mind over matter: could mental training strengthen MS hands?

NCT ID NCT07749690

Symptom relief Sponsor: Abant Izzet Baysal University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This trial tests whether adding mental rotation and motor imagery training to standard physiotherapy can improve upper-extremity function in people with relapsing-remitting multiple sclerosis (RRMS). Participants receive either this cognitive-motor training or an active visual-attention control, alongside conventional physiotherapy, three times a week for six weeks. The study measures changes in hand dexterity, processing speed, and spatial visualization to see if mental practice can translate into real-world motor benefits.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A structured cognitive-motor training program combining laterality recognition, motor imagery, and mental rotation exercises, added to conventional physiotherapy.
What this could lead to
If effective, this training could offer a drug-free way to improve hand and arm function in people with relapsing-remitting MS, potentially enhancing daily independence.
What could go wrong
This is a small, early-stage trial, and the training may not produce meaningful improvements over standard physiotherapy. Results may not apply to all MS patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

54 people

The number who actually took part.

Started

Feb 2024

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosed with definite relapsing-remitting multiple sclerosis by a neurologist according to the revised McDonald criteria * Not experiencing an acute MS relapse * Mini Mental State Examination score ≥24 * No clinical MS relapse within the previous 3 months * No corticosteroid treatment for an MS relapse within the previous 3 months * Expanded Disability Status Scale score between 1.5 and 6.0 * Modified Ashworth Scale score ≤2 * Sufficient communication ability to understand visual and verbal instructions and follow the training protocol * Able to attend at least 80% of the planned sessions * Able to complete the Movement Imagery Questionnaire-3 Exclusion Criteria: * Any medication change within the previous 3 months * Uncorrected severe visual or hearing impairment * A communication disorder preventing the perception of or response to the visual and verbal stimuli used in the study * Participation in another structured upper-extremity rehabilitation program or interventional study during the study period * Presence of an additional neurological disorder * Advanced sensory loss or proprioceptive impairment that could affect participation in the intervention * Botulinum toxin injection within the previous 3 months

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Conditions

The condition(s) this trial relates to.

relapsing-remitting multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Relapsing remitting MS (RRMS)

Contacts and locations

Locations

  • Abant Izzet Baysal University Faculty of Health Science

    Bolu, 14100, Turkey (Türkiye)