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Sleep hormone melatonin tested for knee arthritis pain relief

NCT ID NCT06012175

First seen Nov 20, 2025 · Last updated Apr 30, 2026 · Updated 16 times

Summary

This study tested whether melatonin, a natural sleep hormone, can safely reduce pain in people with knee osteoarthritis. Researchers gave melatonin or a placebo to 340 adults aged 40-80 with moderate knee pain. The main goal was to see if melatonin improves pain scores on a standard arthritis questionnaire.

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Contacts and locations

Locations

  • Xiangya Hospital of Central South University

    Changsha, Hunan, 410000, China

Conditions

Explore the condition pages connected to this study.