New hope for advanced melanoma patients: experimental virus therapy combined with immunotherapy enters phase 3 trial

NCT ID NCT06264180

Recruiting now Disease control Sponsor: Replimune, Inc. Source: ClinicalTrials.gov ↗

First seen Oct 31, 2025 · Last updated May 20, 2026 · Updated 22 times

Summary

This Phase 3 study tests whether an experimental cancer-killing virus (vusolimogene oderparepvec) combined with the immunotherapy nivolumab works better than standard treatments for people with advanced melanoma that has worsened after prior immunotherapy. About 400 participants will be randomly assigned to receive either the combination or a doctor's choice of other therapies. The main goal is to see if the combination helps people live longer.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

Advocate Lutheran General Hospital
WITHDRAWN

Park Ridge, Illinois, 60068, United States
Banner MD Anderson Cancer Center
RECRUITING

Gilbert, Arizona, 85234, United States

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Baptist MD Anderson Cancer Center
RECRUITING

Jacksonville, Florida, 32207, United States

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CHU Nice
RECRUITING

Nice, 06200, France

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CHU de Bordeaux, Hôpital Saint-André
RECRUITING

Bordeaux, 33075, France

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CHU de Lille
RECRUITING

Lille, 59000, France

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Charité - Universitätsmedizin Berlin
RECRUITING

Berlin, 10117, Germany

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Clatterbridge Cancer Centre NHS Foundation Trust
RECRUITING

Liverpool, L7 8YA, United Kingdom

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Clinica Universidad de Navarra - Madrid
RECRUITING

Madrid, 28027, Spain

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Clinica Universidad de Navarra - Pamplona
RECRUITING

Pamplona, 31008, Spain

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Corewell Health
RECRUITING

Grand Rapids, Michigan, 49503, United States

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Dartmouth Hitchcock Cancer Center
RECRUITING

Lebanon, New Hampshire, 03756, United States

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Duke Cancer Center
RECRUITING

Durham, North Carolina, 27710, United States

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Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States

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Guy's & St. Thomas' NHS Foundation Trust
RECRUITING

London, SE1 9RT, United Kingdom

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Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States

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Helios Klinik
RECRUITING

Erfurt, 99089, Germany

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Henry Ford Cancer - Detroit (Brigitte Harris Cancer Pavilion)
WITHDRAWN

Detroit, Michigan, 48202, United States
Hopital de La Timone
RECRUITING

Marseille, 13005, France

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Hospices Civils de Lyon (HCL) - Centre Hospitalier Lyon-Sud
RECRUITING

Pierre-Bénite, 69495, France

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Hospital Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain

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Hospital Clínico Universitario Virgen de la Arrixaca
RECRUITING

El Palmar, 30120, Spain

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Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain

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Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain

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Huntsman Cancer Institute
RECRUITING

Salt Lake City, Utah, 84112, United States

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Hôpital Saint Louis - AP-HP
RECRUITING

Paris, 75010, France

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Institut Gustave Roussy
RECRUITING

Villejuif, 94800, France

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Intermountain Health
RECRUITING

Murray, Utah, 84107, United States

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LMU München - Klinik and Poliklinik für Dermatologie und Allergologie, Dermatoonkologie
RECRUITING

München, 80337, Germany

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MD Anderson Cancer Center at Cooper
WITHDRAWN

Camden, New Jersey, 08103, United States
Maria Sklodowska-Curie National Research Institute of Oncology
RECRUITING

Warsaw, 02-781, Poland

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MedStar Washington Hospital Center
RECRUITING

Washington D.C., District of Columbia, 20010, United States

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Memorial Cancer Institute at Memorial Regional Hospital
RECRUITING

Hollywood, Florida, 33021, United States

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Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States

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Montefiore Medical Center
RECRUITING

The Bronx, New York, 10461, United States

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Morristown Medical Center - Atlantic Health System
RECRUITING

Morristown, New Jersey, 07960, United States

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National and Kapodistrian University of Athens, General Hospital of Athens "Laiko"
RECRUITING

Athens, 11527, Greece

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Northwell Health, R.J. Zuckerberg Cancer Center
RECRUITING

Lake Success, New York, 11042, United States

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Northwestern Memorial Hospital
RECRUITING

Chicago, Illinois, 60611, United States

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Rhode Island Hospital
RECRUITING

Providence, Rhode Island, 02903, United States

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Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States

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Royal Free London NHS Foundation Trust - Royal Free Hospital
RECRUITING

London, NW3 2QG, United Kingdom

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San Francisco Oncology Associates
RECRUITING

San Francisco, California, 94115, United States

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St. George Regional Hospital
WITHDRAWN

St. George, Utah, 84790, United States
Stanford Cancer Institute
RECRUITING

Palo Alto, California, 94304, United States

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Stony Brook University Cancer Center
WITHDRAWN

Stony Brook, New York, 11794, United States
Sutter Medical Group
WITHDRAWN

Sacramento, California, 95816, United States
Texas Oncology
RECRUITING

Dallas, Texas, 75246, United States

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The Angeles Clinic and Research Institute
RECRUITING

Los Angeles, California, 90025, United States

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The Christie NHS Foundation Trust
RECRUITING

Manchester, M20 4BX, United Kingdom

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The Melanoma and Skin Cancer Institute
RECRUITING

Englewood, Colorado, 80113, United States

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The Ohio State University- Martha Morehouse Tower
RECRUITING

Columbus, Ohio, 43210, United States

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The Royal Marsden NHS Foundation Trust
RECRUITING

London, SW3 6JJ, United Kingdom

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The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States

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Thomas Jefferson University
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

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UC Irvine Health, Chao Family Comprehensive Cancer Center
RECRUITING

Orange, California, 92868, United States

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UC San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92037, United States

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UCLA Department of Medicine - Hematology/Oncology
RECRUITING

Los Angeles, California, 90095, United States

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UCSF Helen Diller Family Comprehensive Cancer Center
RECRUITING

San Francisco, California, 94143, United States

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UPMC
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States

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USC Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States

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Universitatsklinikum Mainz Hautklinik und Poliklinik
RECRUITING

Mainz, 55131, Germany

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University Hospital Carl Gustav Carus Dresden
RECRUITING

Dresden, 01307, Germany

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University of Colorado Hospital - Anschutz Cancer Pavilion
RECRUITING

Aurora, Colorado, 80045, United States

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University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States

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University of Kansas Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States

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University of Kiel
RECRUITING

Kiel, 24105, Germany

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University of Louisville Brown Cancer Center
RECRUITING

Louisville, Kentucky, 40202, United States

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University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States

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University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27514, United States

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University of Tennessee
RECRUITING

Knoxville, Tennessee, 37920, United States

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University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States

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University of Vermont Medical Center
RECRUITING

Burlington, Vermont, 05401, United States

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Universitätsklinikum Essen
RECRUITING

Essen, 45147, Germany

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Universitätsklinikum Hospital Heidelberg
RECRUITING

Heidelberg, 69120, Germany

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Universitätsklinikum Medical Center
RECRUITING

Hamburg, 20246, Germany

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Universitätsklinikum of Tübingen
RECRUITING

Tübingen, 72076, Germany

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Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, 80-214, Poland

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West Cancer Center and Research Institute
RECRUITING

Germantown, Tennessee, 38138, United States

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West Virginia University
RECRUITING

Morgantown, West Virginia, 26506, United States

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Winship Cancer Institute, Emory University
RECRUITING

Atlanta, Georgia, 30322, United States

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Conditions

Explore the condition pages connected to this study.

ADVANCED MELANOMA