New triple therapy aims to tame immune side effects in advanced melanoma

NCT ID NCT03999749

Ongoing Disease control Sponsor: NYU Langone Health Source: ClinicalTrials.gov ↗

First seen Mar 28, 2026 · Last updated Apr 24, 2026 · Updated 3 times

Summary

This study tests a three-drug combination for people with advanced melanoma that cannot be removed by surgery. The goal is to see if adding tocilizumab to standard immunotherapy (ipilimumab and nivolumab) can reduce severe immune-related side effects while still controlling the cancer. About 71 participants will receive the drugs over several months, with the main focus on safety and tumor response.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Dana Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
NYU Langone Health

New York, New York, 10016, United States
The Angeles Clinic

Los Angeles, California, 90025, United States

Conditions

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MELANOMA