Could a stretched rectum begin in childhood? new study investigates
NCT ID NCT07599527
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at adults with severe constipation and an enlarged rectum (idiopathic megarectum) to see if the problem started in childhood. Researchers will compare 120 participants—some with the condition and some without—by asking about their early-life digestive health and environmental factors. The goal is to better understand what causes this rare condition, not to test a new treatment.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jun 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
* Patients with idiopathic Mega-Rectum (MI) treated in the Digestive Physiology Department between 2016 and 2026 for the performance of a rectal barostat to confirm the megarectum suspected by anorectal manometry. * Constipated patients recruited consecutively during consultations by physicians in the Digestive Physiology department, and whose anorectal manometry, performed as part of routine care, ruled out the diagnosis of megarectum
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Idiopathic megarectum (IM) group: * Adult patients presenting with chronic constipation according to the Rome criteria; * Patients with megarectum suspected by anorectal manometry and confirmed by rectal barostat; * Isolated, idiopathic megarectum (no known cause); Constipated group: * Constipated adult patients presenting consecutively with chronic functional constipation according to the Rome criteria; * Patients without megarectum suspected by anorectal manometry. Exclusion Criteria: * Patients who are not constipated; * Hirschsprung's disease; * Patients with anorectal malformation; * Patients with known neurological conditions; * Patients with endocrine disorders that may cause constipation; * Patients taking constipating medications such as morphine or neuroleptics; * Patients with a potential organic and/or drug-induced cause of constipation; * Constipation secondary to medication; * Patients unable to complete a questionnaire; * Patients deprived of their liberty, under guardianship, or curatorship
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Digestive Physiology Department
Rouen, 76031, France