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Maitake mushroom extract tested as immune booster for cancer patients

NCT ID NCT06323473

Disease control Sponsor: The Canadian College of Naturopathic Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial is testing whether a liquid extract from maitake mushrooms can improve immune function in 40 adults receiving chemotherapy or CDK4/6 inhibitors for cancer. Participants take the supplement alongside their standard treatment. The study measures changes in white blood cell counts and rates of fever-related low white blood cell counts.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Maitake mushroom extract (Black Maitake Prothera)
What this could lead to
If it works, this could point toward a natural supplement to help support the immune system during cancer treatment.
What could go wrong
This is a small, early-phase trial with no placebo group, so results may not be conclusive. Maitake could interact with other medications or cause allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2024

Expected to finish

May 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adults (≥18 years of age) 2. Confirmed cancer diagnosis through biopsy or radiologic imaging 3. Undergoing systemic treatment with either chemotherapy or CD4/6 inhibitors 4. Currently receiving cancer treatment in Ontario, Canada Exclusion Criteria: 1. Hematologic cancers 2. Previously received any mushroom supplement within 6 months prior to enrolment 3. Allergy to mushrooms or mushroom products 4. Diagnosis of diabetes 5. Currently taking hypoglycemic or anticoagulant medications 6. Currently receiving immune checkpoint inhibitors 7. Unable to attend in in-person visits in either Ottawa or Toronto 8. Any reason which, under the discretion of the Qualified Investigator or delegate, would preclude the patient from participating

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Conditions

The condition(s) this trial relates to.

cancer neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cancer

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Canadian College of Naturopathic Medicine - Integrative Cancer Centre

    RECRUITING

    Toronto, Ontario, M2K 1E2, Canada

  • The Centre for Health Innovation

    RECRUITING

    Ottawa, Ontario, K2P 0M7, Canada

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