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Two-Drug maintenance strategy aims to stall advanced bladder cancer

NCT ID NCT05092958

Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase III trial tests whether adding cabozantinib to avelumab (an immunotherapy) helps keep metastatic urothelial cancer from growing after initial chemotherapy. About 654 patients will receive either the combination or avelumab alone as maintenance therapy. The goal is to see if the combo improves overall survival and delays cancer progression.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cabozantinib and avelumab
What this could lead to
If successful, this combination could become a new standard maintenance therapy to delay cancer progression and extend survival in metastatic bladder cancer.
What could go wrong
This is an advanced trial, but adding cabozantinib may increase side effects without guaranteeing better outcomes. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 654 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2022

Expected to finish

Jul 2029

An estimate. End dates often move.

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Histologically or cytologically-confirmed diagnosis of advanced or metastatic urothelial cancer of the renal pelvis, ureter, bladder, or urethra (transitional cell and mixed transitional/non-transitional cell histologies except for small-cell histology), including N3 only disease prior to start of first-line platinum-based chemotherapy * Prior first-line treatment must have consisted of 4-6 cycles of 1st-line therapy (platinum-based chemotherapy; gemcitabine-cisplatin, gemcitabine-carboplatin, methotrexate, vinblastine, doxorubicin and cisplatin \[MVAC\] or dose-dense \[dd\]MVAC) * No more than 1 line of prior chemotherapy for metastatic or locally advanced disease (neoadjuvant or adjuvant chemotherapy will be allowed if given 12 or more months prior to registration) * Tumor objective response of CR, PR, or SD upon completion of first line platinum-based chemotherapy by treating physician's assessment * The last dose of first-line chemotherapy must have been received no less than 3 weeks, and no more than 10 weeks, prior to randomization in the present study * No prior immunotherapy with IL-2, IFN-alpha, or an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137, or CTLA-4 antibody (including ipilimumab), or any other antibody or drug specifically targeting T-cell co-stimulation or immune checkpoint pathways * Age \>= 18 years * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 * Not pregnant and not nursing, because this study involves an agent that has known genotoxic, mutagenic and teratogenic effects * Women of childbearing potential must have a negative pregnancy test =\< 14 days prior to registration. * Women of childbearing potential include women who have experienced menarche and who have not undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or are not postmenopausal. Post menopause is defined as amenorrhea \>= 12 consecutive months. Note: women who have been amenorrheic for 12 or more months are still considered to be of childbearing potential if the amenorrhea is possibly due to prior chemotherapy, antiestrogens, ovarian suppression or any other reversible reason * No use of immunosuppressive medication within 7 days prior to randomization except: * Intranasal, inhaled, topical steroids, or local steroid injections (e.g., intra-articular injection); * Systemic corticosteroids at physiologic doses =\< 10 mg/day of prednisone or equivalent; * Steroids as premedication for hypersensitivity reactions (e.g., computed tomography \[CT\] scan premedication) * Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial * Patients with diabetes type I, vitiligo, psoriasis, or hypo or hyperthyroid disease not requiring immunosuppressive treatment are eligible * None of the following: * Active autoimmune disease that might deteriorate when receiving the anti PD-L1 agent, avelumab. * No known symptomatic central nervous system (CNS) metastases. Patients with previously diagnosed CNS metastases are eligible if they have completed their treatment and have recovered from the acute effects of radiation therapy or surgery prior to randomization, have discontinued corticosteroid treatment for at least 2 weeks, and are neurologically stable. Baseline brain imaging with contrast-enhanced CT or MRI scans for subjects with known brain metastases is required to confirm eligibility. * No major surgery within 4 weeks prior to randomization. Subjects must have complete wound healing from surgery before randomization. Subjects with clinically relevant ongoing complications from prior surgery are not eligible. * No palliative radiotherapy within 48 hours prior to patient randomization. * No hemoptysis of ≥ 0.5 teaspoon (2.5 mL) of red blood, clinically significant hematuria, hematemesis, coagulopathy, or other history of significant bleeding (eg. Pulmonary hemorrhage) within 3 months before randomization. * No known cavitating pulmonary lesion(s) or known endobronchial disease manifestation. * No administration of a live, attenuated vaccine within 30 days prior to randomization. The use of inactivated (killed) vaccines for the prevention of infectious disease is permitted. The use of COVID-19 vaccines is permitted. * No uncontrolled, significant intercurrent or recent illness including, but not limited to, the following conditions: * Cardiovascular disorders including: * Congestive heart failure (CHF): New York Heart Association (NYHA) class III (moderate) or class IV (severe) at the time of screening. * Concurrent uncontrolled hypertension defined as sustained blood pressure (BP) \> 150 mm Hg systolic, or \> 90 mm Hg diastolic despite optimal antihypertensive treatment. * The patient has a known history of corrected QT interval calculated by the Fridericia formula (QTcF) \> 500 ms and confirmed by electrocardiogram (ECG) within 28 days before randomization. Note: if initial QTcF is found to be \> 500 ms, two additional electrocardiograms (EKGs) separated by at least 3 minutes should be performed. If the average of these three consecutive results for QTcF is ≤ 500 ms, the subject meets eligibility in this regard. * Any history of congenital long QT syndrome. * Stroke, transient ischemic attack (TIA), myocardial infarction, or other symptomatic ischemic event or thromboembolic event (eg, deep venous thrombosis, pulmonary embolism \[DVT/PE\]) within 6 months before randomization. Subjects with a diagnosis of incidental, subsegmental PE or DVT within 6 months are allowed if asymptomatic and stable at screening and treated with low molecular weight heparin (LMWH) or the direct factor Xa inhibitors rivaroxaban, edoxaban, or apixaban for at least 1 week before randomization. Non-symptomatic white matter disease in the brain is acceptable. * No significant gastrointestinal disorders, particularly those associated with a high risk of perforation or fistula formation including unresolved active peptic ulcer disease, cholecystitis, diverticultis, symptomatic cholangitis or appendicitis, or malabsorption syndrome within 28 days of randomization. * No other clinically significant disorders such as: * Any active infection requiring systemic treatment within 14 days before randomization. Subjects receiving oral (including prophylactic) antibiotics with no symptoms of infection at randomization are eligible. * Serious non-healing wound/ulcer/bone fracture within 28 days before randomization * History of organ or allogeneic stem cell transplant * No persisting toxicity related to prior therapy grade \> 2 constituting a safety risk based on the investigator's judgment. * No diagnosis of any other malignancy within 3 years prior to randomization, except for locally curable cancers that have been adequately treated such as basal cell or squamous cell skin cancer, or carcinoma in situ of the breast or of the cervix, Gleason \< 7 prostate cancer on surveillance without any plans for treatment intervention (eg, surgery, radiation, or castration), or prostate cancer that has been adequately treated with prostatectomy or radiotherapy and currently with no evidence of disease or symptoms and no indication for treatment. * No concomitant anticoagulation with coumarin agents (e.g., warfarin), direct thrombin inhibitors (e.g., dabigatran), direct factor Xa inhibitor betrixaban, or platelet inhibitors (e.g., clopidogrel). * Allowed anticoagulants are the following: * Prophylactic use of low-dose aspirin for cardio-protection (per local applicable guidelines) and low-dose low molecular weight heparins (LMWH).Therapeutic doses of LMWH or anticoagulation with direct factor Xa inhibitors rivaroxaban, edoxaban, or apixaban in subjects without known brain metastases who are on a stable dose of the anticoagulant for at least 1 week before first dose of study treatment without clinically significant hemorrhagic complications from the anticoagulation regimen or the tumor * Absolute neutrophil count (ANC) \>= 1,000/mm\^3 * Platelet count \>= 100,000/mm\^3 * Hemoglobin \>= 8 g/dL * Calculated (Calc.) creatinine clearance \>= 30 mL/min using the Cockcroft-Gault equation * Total serum bilirubin =\< 1.5 x upper limit of normal (ULN) * Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =\< 2.5 x ULN (or =\< 5 x ULN for patients with liver metastases or Gilbert's disease) * Urine protein creatinine (UPC) ratio =\< 1 or 24-hour protein \< 1 g * Physicians should consider whether any of the following may render the patient inappropriate for this protocol: * Psychiatric illness which would prevent the patient from giving informed consent. * Uncontrolled medical conditions which, in the opinion of the treating physician, would make this protocol unreasonably hazardous for the patient. * Patients who cannot swallow oral formulations of the agent(s). In addition: * Women and men of reproductive potential should agree to use an appropriate method of birth control throughout their participation in this study due to the teratogenic potential of the therapy utilized in this trial. Include as applicable: Appropriate methods of birth control include abstinence, oral contraceptives, implantable hormonal contraceptives or double barrier method (diaphragm plus condom). * Patients with rheumatoid arthritis and other rheumatologic arthropathies, Sjogren's syndrome and psoriasis controlled with topical medication and or steroids equivalent to \< 10 mg prednisone daily, not on immunosuppressive medications and patients with positive serology are eligible. Patients with vitiligo, endocrine deficiencies including hypo or hyper thyroid disease managed with replacement, diabetes type 1 are eligible. * Sexually active subjects (men and women) must agree to use medically accepted barrier methods of contraception (e.g., male or female condom) during the study and continue for 4 months after the last dose of study drugs, even if oral contraceptives are also used.

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Conditions

The condition(s) this trial relates to.

bladder transitional cell carcinoma infiltrating bladder urothelial carcinoma malignant renal pelvis neoplasm renal pelvis carcinoma renal pelvis urothelial carcinoma renal pelvis/ureter urothelial carcinoma stage IVb bladder cancer ureter cancer ureter transitional cell carcinoma urethra cancer urethra transitional cell carcinoma Urethral Neoplasms Urinary Bladder Neoplasms urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Advanced bladder urothelial carcinoma Advanced renal pelvis urothelial carcinoma Advanced ureter urothelial carcinoma Advanced urethral urothelial carcinoma Metastatic bladder urothelial carcinoma Metastatic renal pelvis urothelial carcinoma Metastatic ureter urothelial carcinoma Metastatic urethral urothelial carcinoma Stage III bladder cancer ajcc V8 Stage III renal pelvis and ureter cancer ajcc V8 Stage III renal pelvis cancer ajcc V8 Stage III ureter cancer ajcc V8 Stage III urethral cancer ajcc V8 Stage IV bladder cancer ajcc V8 Stage IV renal pelvis and ureter cancer ajcc V8 Stage IV renal pelvis cancer ajcc V8 Stage IV ureter cancer ajcc V8 Stage IV urethral cancer ajcc V8

Contacts and locations

Locations

  • AMG Crystal Lake - Oncology

    Crystal Lake, Illinois, 60014, United States

  • AMG Libertyville - Oncology

    Libertyville, Illinois, 60048, United States

  • Abbott-Northwestern Hospital

    Minneapolis, Minnesota, 55407, United States

  • Advocate Christ Medical Center

    Oak Lawn, Illinois, 60453-2699, United States

  • Advocate Good Samaritan Hospital

    Downers Grove, Illinois, 60515, United States

  • Advocate Good Shepherd Hospital

    Barrington, Illinois, 60010, United States

  • Advocate Illinois Masonic Medical Center

    Chicago, Illinois, 60657, United States

  • Advocate Lutheran General Hospital

    Park Ridge, Illinois, 60068, United States

  • Advocate Sherman Hospital

    Elgin, Illinois, 60123, United States

  • Advocate South Suburban Hospital

    Hazel Crest, Illinois, 60429, United States

  • Allan Blair Cancer Centre

    Regina, Saskatchewan, S4T 7T1, Canada

  • Alta Bates Summit Medical Center-Herrick Campus

    Berkeley, California, 94704, United States

  • Arnot Ogden Medical Center/Falck Cancer Center

    Elmira, New York, 14905, United States

  • Atrium Health Cabarrus/LCI-Concord

    Concord, North Carolina, 28025, United States

  • Atrium Health Cleveland/LCI-Cleveland

    Shelby, North Carolina, 28150, United States

  • Atrium Health Lincoln/LCI-Lincolnton

    Lincolnton, North Carolina, 28092, United States

  • Atrium Health University City/LCI-University

    Charlotte, North Carolina, 28262, United States

  • Atrium Medical Center-Middletown Regional Hospital

    Franklin, Ohio, 45005-1066, United States

  • Aurora Bay Area Medical Group-Marinette

    Marinette, Wisconsin, 54143, United States

  • Aurora BayCare Medical Center

    Green Bay, Wisconsin, 54311, United States

  • Aurora Cancer Care-Grafton

    Grafton, Wisconsin, 53024, United States

  • Aurora Cancer Care-Kenosha South

    Kenosha, Wisconsin, 53142, United States

  • Aurora Cancer Care-Milwaukee

    Milwaukee, Wisconsin, 53209, United States

  • Aurora Cancer Care-Milwaukee West

    Wauwatosa, Wisconsin, 53226, United States

  • Aurora Cancer Care-Racine

    Racine, Wisconsin, 53406, United States

  • Aurora Cancer Care-Southern Lakes VLCC

    Burlington, Wisconsin, 53105, United States

  • Aurora Health Care Germantown Health Center

    Germantown, Wisconsin, 53022, United States

  • Aurora Medical Center in Summit

    Summit, Wisconsin, 53066, United States

  • Aurora Saint Luke's Medical Center

    Milwaukee, Wisconsin, 53215, United States

  • Aurora Sinai Medical Center

    Milwaukee, Wisconsin, 53233, United States

  • Aurora West Allis Medical Center

    West Allis, Wisconsin, 53227, United States

  • Avera Cancer Institute

    Sioux Falls, South Dakota, 57105, United States

  • Avera Cancer Institute at Yankton

    Yankton, South Dakota, 57078, United States

  • Avera Cancer Institute-Aberdeen

    Aberdeen, South Dakota, 57401, United States

  • Baptist Health Louisville

    Louisville, Kentucky, 40207, United States

  • Beacon Kalamazoo Cancer Center

    Kalamazoo, Michigan, 49009, United States

  • Beebe Health Campus

    Rehoboth Beach, Delaware, 19971, United States

  • Beebe South Coastal Health Campus

    Millville, Delaware, 19967, United States

  • Bon Secours Memorial Regional Medical Center

    Mechanicsville, Virginia, 23116, United States

  • Bon Secours Saint Francis Medical Center

    Midlothian, Virginia, 23114, United States

  • Bon Secours Saint Mary's Hospital

    Richmond, Virginia, 23226, United States

  • Bronson Battle Creek

    Battle Creek, Michigan, 49017, United States

  • Bronson Methodist Hospital

    Kalamazoo, Michigan, 49007, United States

  • California Pacific Medical Center-Pacific Campus

    San Francisco, California, 94115, United States

  • Cancer Care Center of O'Fallon

    O'Fallon, Illinois, 62269, United States

  • Cancer Care Specialists of Illinois - Decatur

    Decatur, Illinois, 62526, United States

  • Cancer Center of Western Wisconsin

    New Richmond, Wisconsin, 54017, United States

  • Cancer Hematology Centers - Flint

    Flint, Michigan, 48503, United States

  • Cancer and Hematology Centers of Western Michigan - Norton Shores

    Norton Shores, Michigan, 49444, United States

  • Carle Cancer Center

    Urbana, Illinois, 61801, United States

  • Carle Physician Group-Effingham

    Effingham, Illinois, 62401, United States

  • Carle Physician Group-Mattoon/Charleston

    Mattoon, Illinois, 61938, United States

  • Carle at The Riverfront

    Danville, Illinois, 61832, United States

  • Carolinas Medical Center/Levine Cancer Institute

    Charlotte, North Carolina, 28203, United States

  • Centralia Oncology Clinic

    Centralia, Illinois, 62801, United States

  • Chelsea Hospital

    Chelsea, Michigan, 48118, United States

  • Cleveland Clinic Akron General

    Akron, Ohio, 44307, United States

  • Cleveland Clinic Cancer Center Mansfield

    Mansfield, Ohio, 44906, United States

  • Cleveland Clinic Cancer Center Strongsville

    Strongsville, Ohio, 44136, United States

  • Cleveland Clinic Cancer Center/Fairview Hospital

    Cleveland, Ohio, 44111, United States

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • Cleveland Clinic Wooster Family Health and Surgery Center

    Wooster, Ohio, 44691, United States

  • Cleveland Clinic-Weston

    Weston, Florida, 33331, United States

  • Coborn Cancer Center at Saint Cloud Hospital

    Saint Cloud, Minnesota, 56303, United States

  • Condell Memorial Hospital

    Libertyville, Illinois, 60048, United States

  • Corewell Health Grand Rapids Hospitals - Butterworth Hospital

    Grand Rapids, Michigan, 49503, United States

  • Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

    Saint Joseph, Michigan, 49085, United States

  • Corewell Health Reed City Hospital

    Reed City, Michigan, 49677, United States

  • Cross Cancer Institute

    Edmonton, Alberta, T6G 1Z2, Canada

  • Crossroads Cancer Center

    Effingham, Illinois, 62401, United States

  • Dayton Physician LLC - Englewood

    Dayton, Ohio, 45415, United States

  • Drexel Town Square Health Center

    Oak Creek, Wisconsin, 53154, United States

  • Froedtert Menomonee Falls Hospital

    Menomonee Falls, Wisconsin, 53051, United States

  • Froedtert West Bend Hospital/Kraemer Cancer Center

    West Bend, Wisconsin, 53095, United States

  • Genesee Hematology Oncology PC

    Flint, Michigan, 48503, United States

  • Genesys Hurley Cancer Institute

    Flint, Michigan, 48503, United States

  • Glens Falls Hospital

    Glens Falls, New York, 12801, United States

  • Hackensack University Medical Center

    Hackensack, New Jersey, 07601, United States

  • Harold Alfond Center for Cancer Care

    Augusta, Maine, 04330, United States

  • Helen F Graham Cancer Center

    Newark, Delaware, 19713, United States

  • Hematology Oncology Consultants-Clarkston

    Clarkston, Michigan, 48346, United States

  • Hennepin County Medical Center

    Minneapolis, Minnesota, 55415, United States

  • Henry Ford Saint John Hospital - Macomb Medical

    Macomb, Michigan, 48044, United States

  • Hillcrest Hospital Cancer Center

    Mayfield Heights, Ohio, 44124, United States

  • Hope Cancer Center

    Pontiac, Michigan, 48341, United States

  • Hurley Medical Center

    Flint, Michigan, 48503, United States

  • Huron Gastroenterology PC

    Ypsilanti, Michigan, 48106, United States

  • Illinois CancerCare - Washington

    Washington, Illinois, 61571, United States

  • Illinois CancerCare-Bloomington

    Bloomington, Illinois, 61704, United States

  • Illinois CancerCare-Canton

    Canton, Illinois, 61520, United States

  • Illinois CancerCare-Carthage

    Carthage, Illinois, 62321, United States

  • Illinois CancerCare-Dixon

    Dixon, Illinois, 61021, United States

  • Illinois CancerCare-Eureka

    Eureka, Illinois, 61530, United States

  • Illinois CancerCare-Galesburg

    Galesburg, Illinois, 61401, United States

  • Illinois CancerCare-Kewanee Clinic

    Kewanee, Illinois, 61443, United States

  • Illinois CancerCare-Macomb

    Macomb, Illinois, 61455, United States

  • Illinois CancerCare-Ottawa Clinic

    Ottawa, Illinois, 61350, United States

  • Illinois CancerCare-Pekin

    Pekin, Illinois, 61554, United States

  • Illinois CancerCare-Peoria

    Peoria, Illinois, 61615, United States

  • Illinois CancerCare-Peru

    Peru, Illinois, 61354, United States

  • Illinois CancerCare-Princeton

    Princeton, Illinois, 61356, United States

  • Jefferson Methodist Hospital

    Philadelphia, Pennsylvania, 19148, United States

  • Kettering Medical Center

    Kettering, Ohio, 45429, United States

  • Legacy Cancer Institute Medical Oncology and Day Treatment

    Vancouver, Washington, 98684, United States

  • Legacy Good Samaritan Hospital and Medical Center

    Portland, Oregon, 97210, United States

  • Legacy Meridian Park Hospital

    Tualatin, Oregon, 97062, United States

  • Legacy Mount Hood Medical Center

    Gresham, Oregon, 97030, United States

  • Legacy Salmon Creek Hospital

    Vancouver, Washington, 98686, United States

  • Lehigh Valley Hospital - Muhlenberg

    Bethlehem, Pennsylvania, 18017, United States

  • Lehigh Valley Hospital-Cedar Crest

    Allentown, Pennsylvania, 18103, United States

  • Levine Cancer Institute-Ballantyne

    Charlotte, North Carolina, 28277, United States

  • Levine Cancer Institute-Rock Hill

    Rock Hill, South Carolina, 29732, United States

  • Levine Cancer Institute-SouthPark

    Charlotte, North Carolina, 28211, United States

  • MU Health - University Hospital/Ellis Fischel Cancer Center

    Columbia, Missouri, 65212, United States

  • Marshfield Medical Center - Minocqua

    Minocqua, Wisconsin, 54548, United States

  • Marshfield Medical Center - Weston

    Weston, Wisconsin, 54476, United States

  • Marshfield Medical Center-EC Cancer Center

    Eau Claire, Wisconsin, 54701, United States

  • Marshfield Medical Center-Marshfield

    Marshfield, Wisconsin, 54449, United States

  • Marshfield Medical Center-Rice Lake

    Rice Lake, Wisconsin, 54868, United States

  • Marshfield Medical Center-River Region at Stevens Point

    Stevens Point, Wisconsin, 54482, United States

  • Mary Greeley Medical Center

    Ames, Iowa, 50010, United States

  • Mayo Clinic Hospital in Arizona

    Phoenix, Arizona, 85054, United States

  • Mayo Clinic in Florida

    Jacksonville, Florida, 32224-9980, United States

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

  • McFarland Clinic - Ames

    Ames, Iowa, 50010, United States

  • McFarland Clinic - Boone

    Boone, Iowa, 50036, United States

  • McFarland Clinic - Jefferson

    Jefferson, Iowa, 50129, United States

  • McFarland Clinic - Marshalltown

    Marshalltown, Iowa, 50158, United States

  • McFarland Clinic - Trinity Cancer Center

    Fort Dodge, Iowa, 50501, United States

  • MedStar Washington Hospital Center

    Washington D.C., District of Columbia, 20010, United States

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Medical Oncology Hematology Consultants PA

    Newark, Delaware, 19713, United States

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

  • Memorial Hospital East

    Shiloh, Illinois, 62269, United States

  • Memorial Medical Center

    Modesto, California, 95355, United States

  • Memorial Medical Center-Las Cruces

    Las Cruces, New Mexico, 88011, United States

  • Memorial Sloan Kettering Basking Ridge

    Basking Ridge, New Jersey, 07920, United States

  • Memorial Sloan Kettering Bergen

    Montvale, New Jersey, 07645, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Commack

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Monmouth

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan Kettering Nassau

    Uniondale, New York, 11553, United States

  • Memorial Sloan Kettering Westchester

    Harrison, New York, 10604, United States

  • Mercy Hospital Saint Louis

    St Louis, Missouri, 63141, United States

  • Miami Valley Cancer Care and Infusion

    Greenville, Ohio, 45331, United States

  • Miami Valley Hospital North

    Dayton, Ohio, 45415, United States

  • Miami Valley Hospital South

    Centerville, Ohio, 45459, United States

  • Michigan Healthcare Professionals Pontiac

    Pontiac, Michigan, 48341, United States

  • Morristown Medical Center

    Morristown, New Jersey, 07960, United States

  • Munson Medical Center

    Traverse City, Michigan, 49684, United States

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

  • New Hampshire Oncology Hematology PA-Concord

    Concord, New Hampshire, 03301, United States

  • Newland Medical Associates-Clarkston

    Clarkston, Michigan, 48346, United States

  • Newland Medical Associates-Pontiac

    Pontiac, Michigan, 48341, United States

  • North Coast Cancer Care

    Sandusky, Ohio, 44870, United States

  • Northwest Cancer Center - Crown Point

    Crown Point, Indiana, 46307, United States

  • Northwest Cancer Center - Hobart

    Hobart, Indiana, 46342, United States

  • Northwest Cancer Center - Valparaiso

    Valparaiso, Indiana, 46383, United States

  • Northwest Oncology LLC

    Dyer, Indiana, 46311, United States

  • Northwestern Medicine Cancer Center Delnor

    Geneva, Illinois, 60134, United States

  • Northwestern Medicine Cancer Center Kishwaukee

    DeKalb, Illinois, 60115, United States

  • Northwestern Medicine Cancer Center Warrenville

    Warrenville, Illinois, 60555, United States

  • Northwestern Medicine Lake Forest Hospital

    Lake Forest, Illinois, 60045, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • Oklahoma Cancer Specialists and Research Institute-Tulsa

    Tulsa, Oklahoma, 74146, United States

  • OptumCare Cancer Care at Charleston

    Las Vegas, Nevada, 89102, United States

  • OptumCare Cancer Care at Fort Apache

    Las Vegas, Nevada, 89183, United States

  • Overlook Hospital

    Summit, New Jersey, 07902, United States

  • Palo Alto Medical Foundation Health Care

    Palo Alto, California, 94301, United States

  • Palo Alto Medical Foundation-Camino Division

    Mountain View, California, 94040, United States

  • Palo Alto Medical Foundation-Fremont

    Fremont, California, 94538, United States

  • Palo Alto Medical Foundation-Santa Cruz

    Santa Cruz, California, 95065, United States

  • Palo Alto Medical Foundation-Sunnyvale

    Sunnyvale, California, 94086, United States

  • Park Nicollet Clinic - Saint Louis Park

    Saint Louis Park, Minnesota, 55416, United States

  • Penn State Health Medical Group - Andrews Patel Hematology/Oncology East

    Harrisburg, Pennsylvania, 17111, United States

  • Penn State Milton S Hershey Medical Center

    Hershey, Pennsylvania, 17033-0850, United States

  • Premier Blood and Cancer Center

    Dayton, Ohio, 45409, United States

  • Prisma Health Cancer Institute - Butternut

    Greenville, South Carolina, 29605, United States

  • Prisma Health Cancer Institute - Easley

    Easley, South Carolina, 29640, United States

  • Prisma Health Cancer Institute - Eastside

    Greenville, South Carolina, 29615, United States

  • Prisma Health Cancer Institute - Faris

    Greenville, South Carolina, 29605, United States

  • Prisma Health Cancer Institute - Greer

    Greer, South Carolina, 29650, United States

  • Prisma Health Cancer Institute - Seneca

    Seneca, South Carolina, 29672, United States

  • Prisma Health Cancer Institute - Spartanburg

    Boiling Springs, South Carolina, 29316, United States

  • Prisma Health Greenville Memorial Hospital

    Greenville, South Carolina, 29605, United States

  • ProHealth D N Greenwald Center

    Mukwonago, Wisconsin, 53149, United States

  • ProHealth Oconomowoc Memorial Hospital

    Oconomowoc, Wisconsin, 53066, United States

  • ProHealth Waukesha Memorial Hospital

    Waukesha, Wisconsin, 53188, United States

  • Rapid City Regional Hospital

    Rapid City, South Dakota, 57701, United States

  • Regions Hospital

    Saint Paul, Minnesota, 55101, United States

  • Rice Memorial Hospital

    Willmar, Minnesota, 56201, United States

  • Rush MD Anderson Cancer Center

    Chicago, Illinois, 60612, United States

  • Rush-Copley Healthcare Center

    Yorkville, Illinois, 60560, United States

  • Rush-Copley Medical Center

    Aurora, Illinois, 60504, United States

  • SUNY Upstate Medical Center-Community Campus

    Syracuse, New York, 13215, United States

  • Saint Catherine Hospital

    Indianapolis, Indiana, 46312, United States

  • Saint Francis Medical Center

    Cape Girardeau, Missouri, 63703, United States

  • Saint Joseph's Regional Medical Center

    Paterson, New Jersey, 07503, United States

  • Saint Luke's East - Lee's Summit

    Lee's Summit, Missouri, 64086, United States

  • Saint Luke's Hospital of Kansas City

    Kansas City, Missouri, 64111, United States

  • Saint Mary Medical Center

    Hobart, Indiana, 46342, United States

  • Sanford Bismarck Medical Center

    Bismarck, North Dakota, 58501, United States

  • Sanford Broadway Medical Center

    Fargo, North Dakota, 58122, United States

  • Sanford Cancer Center Oncology Clinic

    Sioux Falls, South Dakota, 57104, United States

  • Sanford Joe Lueken Cancer Center

    Bemidji, Minnesota, 56601, United States

  • Sanford Roger Maris Cancer Center

    Fargo, North Dakota, 58122, United States

  • Sanford USD Medical Center - Sioux Falls

    Sioux Falls, South Dakota, 57117-5134, United States

  • Saskatoon Cancer Centre

    Saskatoon, Saskatchewan, S7N 4H4, Canada

  • Shenandoah Oncology PC

    Winchester, Virginia, 22601, United States

  • Siteman Cancer Center at Christian Hospital

    St Louis, Missouri, 63136, United States

  • Siteman Cancer Center at Saint Peters Hospital

    City of Saint Peters, Missouri, 63376, United States

  • Siteman Cancer Center at West County Hospital

    Creve Coeur, Missouri, 63141, United States

  • Siteman Cancer Center-South County

    St Louis, Missouri, 63129, United States

  • Solinsky Center for Cancer Care

    Manchester, New Hampshire, 03103, United States

  • South Pointe Hospital

    Warrensville Heights, Ohio, 44122, United States

  • Southeastern Medical Oncology Center-Clinton

    Clinton, North Carolina, 28328, United States

  • Southeastern Medical Oncology Center-Goldsboro

    Goldsboro, North Carolina, 27534, United States

  • Southeastern Medical Oncology Center-Jacksonville

    Jacksonville, North Carolina, 28546, United States

  • Southern Illinois University School of Medicine

    Springfield, Illinois, 62702, United States

  • Springfield Clinic

    Springfield, Illinois, 62702, United States

  • Springfield Memorial Hospital

    Springfield, Illinois, 62781, United States

  • State University of New York Upstate Medical University

    Syracuse, New York, 13210, United States

  • Stony Brook University Medical Center

    Stony Brook, New York, 11794, United States

  • Sutter Auburn Faith Hospital

    Auburn, California, 95602, United States

  • Sutter Medical Center Sacramento

    Sacramento, California, 95816, United States

  • Sutter Roseville Medical Center

    Roseville, California, 95661, United States

  • Sutter Solano Medical Center/Cancer Center

    Vallejo, California, 94589, United States

  • The Community Hospital

    Munster, Indiana, 46321, United States

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania, 19107, United States

  • Toledo Clinic Cancer Centers-Toledo

    Toledo, Ohio, 43623, United States

  • Trinity Health Grand Rapids Hospital

    Grand Rapids, Michigan, 49503, United States

  • Trinity Health IHA Medical Group Hematology Oncology - Brighton

    Brighton, Michigan, 48114, United States

  • Trinity Health IHA Medical Group Hematology Oncology - Canton

    Canton, Michigan, 48188, United States

  • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

    Chelsea, Michigan, 48118, United States

  • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

    Ypsilanti, Michigan, 48197, United States

  • Trinity Health Medical Center - Brighton

    Brighton, Michigan, 48114, United States

  • Trinity Health Medical Center - Canton

    Canton, Michigan, 48188, United States

  • Trinity Health Muskegon Hospital

    Muskegon, Michigan, 49444, United States

  • Trinity Health Saint Joseph Mercy Hospital Ann Arbor

    Ann Arbor, Michigan, 48106, United States

  • Trinity Health Saint Joseph Mercy Oakland Hospital

    Pontiac, Michigan, 48341, United States

  • Trinity Health Saint Mary Mercy Livonia Hospital

    Livonia, Michigan, 48154, United States

  • UF Health Cancer Institute - Gainesville

    Gainesville, Florida, 32610, United States

  • UMass Memorial Medical Center - University Campus

    Worcester, Massachusetts, 01655, United States

  • UT Southwestern Clinical Center at Richardson/Plano

    Richardson, Texas, 75080, United States

  • UT Southwestern Simmons Cancer Center - RedBird

    Dallas, Texas, 75237, United States

  • UT Southwestern/Simmons Cancer Center-Dallas

    Dallas, Texas, 75390, United States

  • UT Southwestern/Simmons Cancer Center-Fort Worth

    Fort Worth, Texas, 76104, United States

  • UW Cancer Center at ProHealth Care

    Waukesha, Wisconsin, 53188, United States

  • UW Health Carbone Cancer Center Rockford

    Rockford, Illinois, 61114, United States

  • University Cancer Specialists - Alcoa

    Alcoa, Tennessee, 37701, United States

  • University Health Network-Princess Margaret Hospital

    Toronto, Ontario, M5G 2M9, Canada

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California, 95817, United States

  • University of Illinois

    Chicago, Illinois, 60612, United States

  • University of Iowa/Holden Comprehensive Cancer Center

    Iowa City, Iowa, 52242, United States

  • University of Michigan Health - Sparrow Lansing

    Lansing, Michigan, 48912, United States

  • University of Michigan Health - West

    Wyoming, Michigan, 49519, United States

  • University of New Mexico Cancer Center

    Albuquerque, New Mexico, 87106, United States

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, 73104, United States

  • University of Tennessee - Knoxville

    Knoxville, Tennessee, 37920, United States

  • Upper Valley Medical Center

    Troy, Ohio, 45373, United States

  • Upstate Cancer Center at Oswego

    Oswego, New York, 13126, United States

  • Upstate Cancer Center at Verona

    Verona, New York, 13478, United States

  • VCU Community Memorial Health Center

    South Hill, Virginia, 23970, United States

  • VCU Massey Cancer Center at Stony Point

    Richmond, Virginia, 23235, United States

  • VCU Massey Comprehensive Cancer Center

    Richmond, Virginia, 23298, United States

  • Valley Medical Center

    Renton, Washington, 98055, United States

  • Vince Lombardi Cancer Clinic - Oshkosh

    Oshkosh, Wisconsin, 54904, United States

  • Vince Lombardi Cancer Clinic-Sheboygan

    Sheboygan, Wisconsin, 53081, United States

  • Vince Lombardi Cancer Clinic-Two Rivers

    Two Rivers, Wisconsin, 54241, United States

  • Virginia Cancer Institute

    Richmond, Virginia, 23229, United States

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, 27157, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • West Michigan Cancer Center

    Kalamazoo, Michigan, 49007, United States

  • West Virginia University Charleston Division

    Charleston, West Virginia, 25304, United States

  • Women's Diagnostic Center - Munster

    Munster, Indiana, 46321, United States

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