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Could a simple mineral prevent heart trouble in the ICU?

NCT ID NCT05829317

Prevention Sponsor: Dr. Stephanie Sibley Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether giving magnesium through an IV can prevent new-onset atrial fibrillation (a type of irregular heartbeat) in critically ill patients in the intensive care unit. Researchers will enroll 200 adults and randomly assign them to receive either magnesium or a placebo. The main goal is to see if the study procedures are practical, not yet to prove the treatment works.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Magnesium sulfate
What this could lead to
If it works, this could point toward a simple, low-cost way to prevent a common heart complication in ICU patients.
What could go wrong
This is a small pilot study focused on feasibility, not effectiveness. It may not show a clear benefit, and results may not apply to all ICU patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2023

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria 1. Age ≥18 years; 2. Admitted to an ICU with one or more of the following: 1. Non-invasive ventilation (including CPAP, Bipap and high flow oxygen (\>10L/min) or invasive mechanical ventilation with an expected duration \>24 hours for respiratory failure (hypercarbic or hypoxic) 2. Vasopressor or inotropic support with an expected duration of \>24 hours 3. Cardiac arrest 3. Continuous cardiac monitoring. Exclusion Criteria 1. Receiving ICU intervention (Non-invasive ventilation (including high flow nasal canula), invasive mechanical ventilation or inotropic support) for \>18 hours 2. Receiving IMV for airway protection only (for example, isolated head trauma) 3. Active atrial fibrillation at the time of enrolment 4. On oral or continuous infusion of Amiodarone 5. Unlikely to survive \>24 hours or palliative patients 6. Cardiac surgery patients 7. Patients requiring parenteral magnesium therapy (e.g. pre-eclampsia, asthma) 8. Patients receiving dialysis 9. Positive pregnancy test (females \<50 years old) 10. Previously enrolled in this trial 11. Treating physician refuses enrollment

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Conditions

The condition(s) this trial relates to.

Critical Illness atrial fibrillation prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Critical illness New onset atrial fibrillation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    4 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Kingston Health Sciences Centre

    RECRUITING

    Kingston, Ontario, K7L2V7, Canada

  • St Joseph's Healthcare Hamilton

    NOT_YET_RECRUITING

    Hamilton, Ontario, L8N 1Y3, Canada

  • The Ottawa Hospital - Civic Campus

    NOT_YET_RECRUITING

    Ottawa, Ontario, K1Y 4E9, Canada

  • The Ottawa Hospital - General Campus

    NOT_YET_RECRUITING

    Ottawa, Ontario, K1H 8L6, Canada

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