New combo aims to shrink KRAS lung tumors before surgery
NCT ID NCT05118854
First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 24 times
Summary
This study tests whether giving a targeted pill (sotorasib) together with standard chemotherapy before surgery can improve outcomes for people with a certain genetic type of lung cancer (KRAS G12C mutation). About 27 adults with stage IIA to IIIB non-squamous lung cancer that can be removed will receive the drug combination for 4 cycles, then have surgery. The main goal is to see if this approach leads to a major reduction in tumor cells in the removed tissue.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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M D Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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