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Which reflux treatment works best? major trial to find out

NCT ID NCT07611162

Disease control Sponsor: University of Mons Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will compare five treatments for laryngopharyngeal reflux disease (LPRD) in 800 adults. Participants will receive either alginate, magaldrate, sucralfate, a proton pump inhibitor, or a special diet for three months. Researchers will measure symptom improvement to see which approach is most effective.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
alginate, magaldrate, sucralfate, proton pump inhibitors, and diet
What this could lead to
If successful, this study could identify which treatment works best for laryngopharyngeal reflux, helping doctors choose the most effective and tolerable option.
What could go wrong
This is a single trial with 800 participants, and results may not apply to everyone. The study hasn't started yet, so outcomes are uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 800 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

May 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Positive 24-h HEMII-pH \> 1 event Exclusion Criteria: * Smoker (\>5 cigarettes/day) , alcohol dependence (\>3 units/day), * upper respiratory tract infection within the last month, * pregnancy, * neurological or psychiatric illness, * previous history of neck surgery or trauma, * malignancy, * history of head and neck radiotherapy * active seasonal allergies or asthma.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Laryngopharyngeal reflux disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Mons

    Mons, 7000, Belgium