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Could adjusting lung pressure during spine surgery prevent dangerous blood pressure drops?

NCT ID NCT06378710

Knowledge-focused Sponsor: University Hospital, Caen Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study investigates whether using lower pressure on the lungs (PEEP) along with extra fluids can prevent blood pressure drops in patients undergoing spine surgery in the knee-chest position. The knee-chest position naturally lowers blood pressure, and standard protective lung ventilation may worsen this effect. Researchers will compare a low-PEEP approach with standard care in 84 adults to see which better maintains stable blood pressure during surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to safer anesthesia practices for spine surgery, reducing dangerous drops in blood pressure.
What could go wrong
This is a small, early-stage study focused on monitoring, not treatment. Results may not apply to all patients or surgeries.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

84 people

The number who actually took part.

Started

Jan 2023

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient \> 18 years old * Beneficiary of Social Security or CMU * Surgical operation under general anesthesia requiring a knee-pectoral position * Dated and signed informed consent Exclusion Criteria: * BMI \> 35 kg/m² * Hemodynamic instability before placing the knee in the pectoral position. * ASA class IV or V * Prolonged intervention \> 2 hours * Lack of consent * Contraindications to the use of esophageal Doppler * Concomitant third-party clinical trial that may induce a hemodynamic or respiratory change in the patient

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Surgery

Contacts and locations

Locations

  • CAEN University Hospital

    Caen, France

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