Triple threat: Low-Dose radiation plus chemo and immunotherapy takes on tough lung cancer

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Main Inclusion Criteria: 1. Histologically or cytologically confirmed ES-SCLC 2. No prior treatment for ES-SCLC 3. Measurable disease, as defined by RECIST v1.1. Previously irradiated lesions can be considered as measurable disease only if progressive disease has been unequivocally documented at that site since radiation. 4. ECOG performance status of 0 or 1 5. Life expectancy \>= 3 months 6. Adequate hematologic and end-organ function 7. For participants receiving therapeutic anticoagulation: stable anticoagulant regimen 8. Negative human immunodeficiency virus (HIV) test at screening 9. Negative hepatitis B surface antigen (HBsAg) test at screening 10. Positive hepatitis B surface antibody (HBsAb) test at screening, or negative HBsAb at screening accompanied by either of the following: Negative total hepatitis B core antibody (HBcAb), or positive total HBcAb test followed by a negative hepatitis B virus (HBV) DNA test. The HBV DNA test will be performed only for participants who have a negative HBsAg test, a negative HBsAb test, and a positive total HBcAb test. 11. Negative hepatitis C virus (HCV) antibody test at screening, or positive HCV antibody test followed by a negative HCV RNA test at screening. The HCV RNA test will be performed only for participants who have a positive HCV antibody test. 12. For women of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraception 13. For men: agreement to remain abstinent (refrain from heterosexual intercourse) or use a condom, and agreement to refrain from donating sperm Main Exclusion Criteria: 1. Symptomatic, untreated, or actively progressing central nervous system (CNS) metastases 2. Participants with pulmonary artery invasion 3. History of leptomeningeal disease 4. Uncontrolled tumor-related pain 5. Uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent drainage procedures 6. Uncontrolled or symptomatic hypercalcemia 7. Active or history of autoimmune disease or immune deficiency 8. History of idiopathic pulmonary fibrosis, organizing pneumonia, drug-induced pneumonitis, or idiopathic pneumonitis, or evidence of active pneumonitis on screening chest computed tomography (CT) scan 9. Active tuberculosis 10. Significant cardiovascular disease within 3 months prior to initiation of study treatment, unstable arrhythmia, or unstable angina 11. History of malignancy other than small cell lung cancer (SCLC) within 5 years prior to screening, with the exception of malignancies with a negligible risk of metastasis or death