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New pill could help when blood pressure meds Aren't enough

NCT ID NCT05769608

Disease control Sponsor: Mineralys Therapeutics Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested an experimental drug called lorundrostat in 285 adults whose high blood pressure remained uncontrolled despite taking 2 to 5 other medications. The drug works by blocking a hormone that raises blood pressure. Researchers measured how much it lowered blood pressure over 24 hours compared to a placebo. The goal is to find a better option for people whose hypertension is difficult to manage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

285 people

The number who actually took part.

Started

Mar 2023

Finished

Jan 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. At least 18 years of age at the time of signing the informed consent form 2. At Screening: AOBP SBP of 140-180 mmHg and AOBP DBP of 65-110 mmHg, or AOBP DBP of 90-110 mmHg 3. 24-hour average ABPM SBP of 130-180 mmHg or 24-hour average ABPM DBP \>80 mmHg 4. Taking between 2 and 5 AHT medications, inclusive, at Screening visit. 5. BMI of 18-40 kg/m2 inclusive at Screening Exclusion Criteria: 1. eGFR \<45 mL/min/1.73 m2 at Screening, calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula 2. Serum potassium \>5.0 mmol/L at Screening or \>4.8 mmol/L at Randomization 3. Serum sodium \<135 mmol/L at Screening 4. History of heart failure, myocardial infarction, stroke, or transient ischemic attack within 6 months prior to Screening. 5. Diabetes mellitus with a glycosylated hemoglobin (HbA1c) \>9% (\>74.9 mmol/mol) at Screening

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Conditions

The condition(s) this trial relates to.

hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypertension

Contacts and locations

Locations

  • ACRC Trials

    Plano, Texas, 75024, United States

  • AMS Cardiology

    Horsham, Pennsylvania, 19044, United States

  • Accel Research Sites

    Decatur, Georgia, 30030, United States

  • Accelerated Enrollment Solutions (AES)- Anderson

    Anderson, South Carolina, 29621, United States

  • Accelerated Enrollment Solutions (AES)- Vista

    Vista, California, 92083, United States

  • ActivMed Practices & Research, LLC

    Methuen, Massachusetts, 01844, United States

  • Advanced Internal Medicine, PLLC (Elligo Health Research)

    Paducah, Kentucky, 42001, United States

  • Albany Medical College Div of Community Endocrinology

    Albany, New York, 12203, United States

  • Alta Pharmaceutical Research Center

    Peachtree Corners, Georgia, 30092, United States

  • Asheville Clinical Trials (Elite Clinical Network)

    Asheville, North Carolina, 28803, United States

  • Blue Coast Research Center

    Vista, California, 92081, United States

  • Boston Clinical Trials

    Boston, Massachusetts, 02131, United States

  • Brown Road Family Medicine

    Mesa, Arizona, 85213, United States

  • Burke Internal Medicine

    Burke, Virginia, 22015, United States

  • CMR of Greater New Haven

    Hamden, Connecticut, 06517, United States

  • Cambridge Clinical Trials

    Alexandria, Louisiana, 71301, United States

  • Cardiology, P.C. - Birmingham

    Birmingham, Alabama, 35211, United States

  • Catalina Research Institute

    Montclair, California, 91763, United States

  • Cedars-Sinai Medical Center

    Los Angeles, California, 90048, United States

  • Centricity Research (Aventiv Research) - Women's Health

    Dublin, Ohio, 43016, United States

  • Centricity Research (IACT Health) (Hampton Roads Center For Clinical Research, Inc.)) - Suffolk Multispecialty Research

    Suffolk, Virginia, 23435, United States

  • Chandler Clinical Trials

    Chandler, Arizona, 85224, United States

  • Charlottesville Medical Research

    Charlottesville, Virginia, 22911, United States

  • Chattanooga Medical Research

    Chattanooga, Tennessee, 37404, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Clinical Investigations of Texas (CIT)

    Plano, Texas, 75075, United States

  • Clinical Neuroscience Solutions, INC.

    Orlando, Florida, 32801, United States

  • Clinical Neuroscience Solutions, Inc

    Memphis, Tennessee, 38119, United States

  • Clinical Neuroscience Solutions, Inc (Jacksonville)

    Jacksonville, Florida, 32256, United States

  • Clinical Research of West Florida, Inc.

    Tampa, Florida, 33606, United States

  • Clinical Trials Research

    Lincoln, California, 95648, United States

  • Coastal Carolina Research Center

    North Charleston, South Carolina, 29405, United States

  • Columbia University

    New York, New York, 10032, United States

  • David Turbay, MD, PLLC (Elligo Health Research)

    El Paso, Texas, 79905, United States

  • Del Sol Research Management, LLC

    Tucson, Arizona, 85715, United States

  • Delta Waves, Inc.

    Colorado Springs, Colorado, 80918, United States

  • Diabetes and Endocrinology Associates of Stark County, Inc.

    Canton, Ohio, 44718, United States

  • Duke University Medical Center Heart Center Clinical Research Unit

    Durham, North Carolina, 27710, United States

  • Eagle Clinical Research

    Chicago, Illinois, 60621, United States

  • East Carolina University (ECU) Physicians - East Carolina Heart Institute - East Carolina University Location

    Greenville, North Carolina, 27834, United States

  • Eastern Virginia Medical School

    Norfolk, Virginia, 23510, United States

  • Elligo Health Research

    Austin, Texas, 78704, United States

  • Fellows Research Alliance, Inc

    Savannah, Georgia, 31406, United States

  • Fiel Family & Sports Medicine

    Tempe, Arizona, 85383, United States

  • Franciscan Physician Network-Indiana Heart Physicians

    Indianapolis, Indiana, 46237, United States

  • GenHarp Clinical Solutions

    Evergreen Park, Illinois, 60805, United States

  • Georgia Clinical Research, LLC

    Lawrenceville, Georgia, 30044, United States

  • Gulf Coast Clinical Research

    Houston, Texas, 77070, United States

  • Henderson Clinical Trials

    Henderson, Nevada, 89052, United States

  • Houston Methodist Research Institute

    Houston, Texas, 77030, United States

  • Indago Research & Health Center, Inc.

    Hialeah, Florida, 33012, United States

  • Indiana Clinical Research

    Merrillville, Indiana, 46410, United States

  • Intrepid Research

    Cincinnati, Ohio, 45245, United States

  • Iredell Memorial Hospital, Inc (Elligo Health Research)

    Statesville, North Carolina, 28677, United States

  • Juno Research LLC

    Houston, Texas, 77040, United States

  • Las Vegas Clinical Trials

    Las Vegas, Nevada, 89030, United States

  • Lifedoc Research

    Memphis, Tennessee, 38115, United States

  • Lillestol Research LLC

    Fargo, North Dakota, 58104, United States

  • Lucas Research, Inc.

    New Bern, North Carolina, 28557, United States

  • Marian David, MD, PC (Elligo Health Research)

    New York, New York, 11415, United States

  • Marvel Clinical Research

    Huntington Beach, California, 92647, United States

  • Medical Colleagues of Texas, LLP (Elligo Health Research)

    Katy, Texas, 77450, United States

  • Medical Colleagues of Texas, LLP (Elligo Health Research)

    Paris, Texas, 75462, United States

  • Nephrology Associates, PC - Downtown Augusta

    Augusta, Georgia, 30901, United States

  • Noble Clinical Research

    Tucson, Arizona, 85704, United States

  • Northridge Clinical Trials

    Northridge, California, 91325, United States

  • Nuovida Research Center Corp

    Miami, Florida, 33186, United States

  • Oasis Clinical Trials

    Las Vegas, Nevada, 89121, United States

  • PRX Research - Mesquite

    Mesquite, Texas, 75149, United States

  • Patron Medical - Andres Patron D.O. (Patron Ventures, LLC)

    Pembroke, Florida, 33026, United States

  • Pennington Biomedical Research Center

    Baton Rouge, Louisiana, 70808, United States

  • Progressive Medical Research

    Port Orange, Florida, 32127, United States

  • Punzi Medical Center

    Carrollton, Texas, 75006, United States

  • Quality Clinical Research Inc. (QCR) - Omaha

    Omaha, Nebraska, 68114, United States

  • Randomize Now

    Peachtree City, Georgia, 30269, United States

  • Renown Regional Medical Center

    Reno, Nevada, 89502, United States

  • Research Innovations (Elligo Health Research)

    Beavercreek, Ohio, 45431, United States

  • Reserka, LLC

    Miami, Florida, 33176, United States

  • STAT Research

    Springboro, Ohio, 45066, United States

  • Saint Louis University

    St Louis, Missouri, 63104, United States

  • San Antonio Clinical Trials

    San Antonio, Texas, 78240, United States

  • San Jose Clinical Trials

    San Jose, California, 95117, United States

  • Scottsdale Clinical Trials (Elite Clinical Network)

    Scottsdale, Arizona, 85260, United States

  • Seacoast Kidney & Hypertension Specialist

    Portsmouth, New Hampshire, 03801, United States

  • Southern Illinois School of Medicine

    Springfield, Illinois, 62702, United States

  • Sugar Lakes Family Practice (Elligo Health Research)

    Sugar Land, Texas, 77479, United States

  • Sun Research Institute (SRI) - San Antonio

    San Antonio, Texas, 78215, United States

  • Synergy Groups Medical - Bissonet Site

    Katy, Texas, 77494, United States

  • The Medical Research Group Inc.

    Fresno, California, 93720, United States

  • The Pierone Research Institute (Elligo Health Research)

    Vero Beach, Florida, 32960, United States

  • The Research Group of Lexington, LLC

    Lexington, Kentucky, 40503, United States

  • The University of Chicago Medicine

    Chicago, Illinois, 60637, United States

  • The University of Utah

    Salt Lake City, Utah, 84108, United States

  • Triad Internal Medicine

    Asheboro, North Carolina, 27205, United States

  • Triwest Research Associates

    San Diego, California, 92108, United States

  • University of Alabama at Birmingham (UAB) - Vascular Biology and Hypertension Program

    Birmingham, Alabama, 35294, United States

  • University of Buffalo

    Buffalo, New York, 14215, United States

  • University of California Irvine Medical Center

    Orange, California, 92868, United States

  • University of California San Diego (UCSD) - Altman Clinical and Translational Research Institute (ACTRI)

    La Jolla, California, 92037, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • Vanderbilt University Medical Center (VUMC)

    Nashville, Tennessee, 37232, United States

  • Versailles Family Medicine

    Versailles, Kentucky, 40383, United States

  • WR- Notus Clinical Trials, LLC

    Charleston, South Carolina, 29414, United States

  • Williamette Valley Clincial Studies

    Eugene, Oregon, 97404, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.