Targeted pill may shrink lung tumors before surgery in new trial

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age :18 Years to 75 Years; * ECOG physical score 0-2 points; expected survival time ≥ 1 year; * Pathologically confirmed diagnosis with Stage III NSCLC which harbored ALK fusion detected by next generation sequencing (NGS) or immunohistochemistry (IHC) with or without FISH. Suspected N2 (station 2/4/7) for stage III disease should be confirmed by either mediastinoscopy or EBUS. * At least one measurable target lesion according to the RECIST 1.1 standard; * The main organ function meets the following criteria: 1) blood routine: absolute value of neutrophils ≥ 1.5 × 109 / L, platelets ≥ 75 × 109 / L, hemoglobin ≥ 80 g / L; 2) blood biochemistry: total bilirubin ≤ 1.5 times the upper limit of normal value, aspartate aminotransferase and alanine aminotransferase ≤ 2.5 times the upper limit of normal value (if liver metastasis, ≤ upper limit of normal value 5 times), serum creatinine ≤ 1.5 times the upper limit of normal; * Subjects voluntarily joined the study and signed informed consent, with good compliance to follow-up. Exclusion Criteria: * Stage I, stage II and metastatic stage IV NSCLC; * Histologically confirmed small cell lung cancer (including lung cancer mixed with small cell lung cancer and non-small cell lung cancer); * Patients who have previously used any other anti-tumor drugs or received surgery/radiotherapy; * Patients with any underlying disease that investigators consider it may affect patient's prognosis including sever cardiovascular, pulmonary disease or serious infections. * Clinically obvious gastrointestinal abnormalities, which may affect the intake, transport or absorption of drugs (such as inability to swallow, chronic diarrhea, intestinal obstruction, etc.), or patients with total gastrectomy; * Pregnant or lactating women; those who have fertility are unwilling or unable to take effective contraceptive measures; * Patients with low compliance or willingness to take the drugs and surveillance.