Tracking Kids' hearts years after rare COVID-19 complication
NCT ID NCT05287412
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study follows 1,200 children and young adults who had MIS-C, a rare inflammatory condition linked to COVID-19. Researchers will track heart function and other health outcomes over time using echocardiograms and medical records. The goal is to understand the long-term effects of MIS-C and improve care for affected children.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could reveal how MIS-C affects children's hearts and overall health in the long run, guiding future care and monitoring.
- What could go wrong
- This is an observational study, not a treatment trial. It cannot prove what causes long-term issues, and results may take years to emerge.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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1,200 people
The number who actually took part.
- Started
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Sep 2020
- Expected to finish
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Jul 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
children and young adults \<21 years with Multisystem Inflammatory Syndrome in Children associated with COVID-19 (MIS-C) at a participating hospital
- Ages
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Up to 21 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age \<21 years. 2. Fever ≥38°C for ≥24 hours, or report of subjective fever lasting ≥24 hours. 3. Laboratory evidence of inflammation, including, but not limited to, one or more of the following: an elevated CRP, ESR, fibrinogen, procalcitonin, d-dimer, ferritin, LDH, or IL-6, elevated neutrophils, reduced lymphocytes and low albumin. 4. Evidence of clinically severe illness requiring hospitalization, with multisystem (≥2) organ involvement, based on clinical judgment from record review, discharge diagnosis, laboratory or diagnostic tests. Organ system involvement includes but is not limited to cardiac, renal, respiratory, hematologic including coagulopathy, gastrointestinal including liver, dermatologic or neurological. 5. Positive for current or recent SARS-CoV-2 infection by RT-PCR, serology, or antigen test; or COVID-19 exposure within the 4 weeks prior to the onset of symptoms Exclusion Criteria: * No plausible alternative diagnosis, such as bacterial sepsis, murine typhus, staphylococcal or streptococcal shock syndromes
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ann & Robert Lurid Children's Hospital of Chicago
Chicago, Illinois, 60611, United States
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Baylor /Texas Children's Hospital
Houston, Texas, 77030, United States
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Boston Children's Hospital
Boston, Massachusetts, 02115, United States
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CS Mott Children's Hospital/University of Michigan
Ann Arbor, Michigan, 48109, United States
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Children's Hospital Los Angeles
Los Angeles, California, 90027, United States
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Children's Hospital of Colorado
Aurora, Colorado, 80045, United States
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Children's Hospital of Michigan
Detroit, Michigan, 48201, United States
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Children's Hospital of New Orleans
New Orleans, Louisiana, 70118, United States
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Children's Medical Center of Dallas - UT Southwestern Medical Center
Dallas, Texas, 75235, United States
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Children's Mercy Hospital
Kansas City, Missouri, 64108, United States
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Children's National Hospital
Washington D.C., District of Columbia, 20010, United States
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Chldren's Healthcare of Atlanta
Atlanta, Georgia, 30322, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Cohen Children's Medical Center
Queens, New York, 11040, United States
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Dell Medical Center
Austin, Texas, 78707, United States
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Duke Children's Hospital and Health Center
Durham, North Carolina, 27705, United States
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Joe DiMaggio Children's Hospital
Hollywood, Florida, 33021, United States
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Medical College of Wisconsin/Children's Hospital of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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Morgan Stanley Children's Hospital of New York
New York, New York, 10032, United States
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Nicklaus Children's Hospital
Miami, Florida, 33155, United States
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Phoenix Children's Hospital
Phoenix, Arizona, 85016, United States
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Primary Children's Hospital
Salt Lake City, Utah, 84113, United States
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Riley Children's Hospital
Indianapolis, Indiana, 46202, United States
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Seattle Children's Hospital
Seattle, Washington, 98105, United States
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The Hospital for Sick Children
Toronto, Ontario, Canada
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The Nemours Foundation
Wilmington, Delaware, 19808, United States
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UC San Diego, Rady Children's Hospital
San Diego, California, 92131, United States
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University of Alabama
Tuscaloosa, Alabama, 35401, United States
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University of Mississippi
Jackson, Mississippi, 39216, United States
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University of North Carolina
Chapel Hill, North Carolina, 27514, United States
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Valley Children's Healthcare and Hospital
Madera, California, 93636, United States
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