Can we predict who returns to work after stress treatment?

NCT ID NCT07757997

Knowledge-focused Sponsor: Clinica Holistica Engiadina Source: ClinicalTrials.gov ↗

First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time

Summary

This study follows people who received inpatient treatment for stress-related conditions like depression, adjustment disorder, or burnout. Researchers will track their health and work ability for up to three years after discharge, using online questionnaires. The goal is to understand how these factors evolve over time and what influences a successful return to work.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to: If successful, this could identify factors that help people return to work after treatment for stress-related disorders, potentially improving rehabilitation programs.
What could go wrong: This is an observational follow-up study, so it cannot prove cause and effect. Results may be limited by participant dropout or self-report bias.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 143 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants of the HARMODI study had the following inclusion criteria: * diagnosis of depressive episode (F32 or F33) as well as burnout (Z73) without psychotic symptoms according to ICD-10, * German language skills, * smartphone ownership, * age 18-65 years. Exclusion criteria: * comorbid post-traumatic stress disorder as well as anxiety and panic disorder * current treatment with antiarrhythmic drugs and tricyclic antidepressant medication * history of cardiac diseases such as myocardial infarction, stroke and unstable heart failure within the previous six months impairing exercise testing and training, * heart failure (NYHA III and IV) * type 1 \& 2 diabetes mellitus with cardiovascular autonomic neuropathy, * COPD GOLD stage ≥ III, * ongoing cancer treatment, * moderate to severe chronic kidney disease (eGFR stage 3a (G3a) or worse (≤ 45 ml/min)), * current anorexia nervosa and bulimia nervosa, * drug or alcohol abuse, * known pregnancy, * suicidal thoughts

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Previously participatiom in the HARMODI study (No. 2022-01871) * Completion of inpatient treatment at the Clinica Holistica Engiadina Exclusion Criteria: * Withdraw of consent for participation in the HARMODI study. * Participants who cannot be reached despite predefined contact attempts (e.g., invalid email or postal address or telephone number)

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Conditions

The condition(s) this trial relates to.

adjustment disorder Burnout, Psychological Depression major depressive disorder occupation-related stress disorder Psychological Well-Being

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adjustment disorder Burnout syndrome Depression - major depressive disorder

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

2 sites. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Can we predict who returns to work after stress treatment?

What the study statuses mean