Gene therapy survivors monitored for years in massive safety study

NCT ID NCT03435796

Knowledge-focused Sponsor: Celgene Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Sep 18, 2026 · Updated 6 times

Summary

This study follows over 1,500 children and adults who previously received gene-modified T cell therapy for cancer. Researchers will track side effects, how long the modified cells last, and overall survival for up to 15 years. No new treatment is given—the goal is to understand long-term safety and effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to: If successful, this study could provide crucial safety data to support future approvals of gene-modified T cell therapies for cancer.
What could go wrong: This is a follow-up study, not a treatment trial. It cannot prove the therapy works, and results may take years. Some patients may experience delayed side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

About 1,541 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2018

Expected to finish

May 2043

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Received at least one gene-modified (GM) T-cell infusion in a previous Celgene sponsored, Juno Therapeutics, other affiliates of BMS, or Celgene alliance partner-sponsored trial, and have discontinued, or completed the post-treatment follow-up period in the parent treatment protocol, as applicable. * Must understand and voluntarily sign an Informed Consent Form/Informed Assent Form prior to any study-related assessments/procedures being conducted. Exclusion Criteria: Not Applicable Other protocol-defined inclusion/exclusion criteria apply

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Get notified about this study

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Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Neoplasms

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

176 sites in 22 countries. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

Allgemeinen Krankenhaus (AKH) Wien - Medizinische Universitaet Wien
RECRUITING

Vienna, 1090, Austria
Asan Medical Center (AMC)
RECRUITING

Seoul, 5505, South Korea
Azienda Ospedaliero Universitaria Di Bologna Policlinico Sorsola Malpighi
RECRUITING

Bologna, 40138, Italy
Azienda Sanitaria Ospedaliera San Giovanni Battista Molinette
RECRUITING

Turin, 10126, Italy
Banner MD Anderson Cancer Center
RECRUITING

Gilbert, Arizona, 85234, United States
Baptist Cancer Center
RECRUITING

Miami, Florida, 33176, United States
CHRU de Lille France
RECRUITING

Lille, 59037, France
CHU La Miletrie
RECRUITING

Poitiers, 86021, France
CHU Montpellier - Hôpital Saint Eloi
RECRUITING

Montpellier, 34295, France
CIUSSS de l'Est-de-l'Ile-de-Montreal
RECRUITING

Montreal, Quebec, H1T 2M4, Canada
Cancer Center of Kansas
RECRUITING

Wichita, Kansas, 67214, United States
Centre Hospitalier Lyon-Sud
RECRUITING

Pierre-Bénite, 69495, France
Centre Hospitalier Regional Universitaire (CHRU) Montpellier Arnaud de Villeneuve
RECRUITING

Montpellier, 34295, France
Centre Hospitalier Universitaire (CHU) de Bordeaux - Hopital Haut-Leveque
RECRUITING

Pessac, 33600, France
Charite-Universitaetsmedizin Berlin - Campus Charite Mitte (CCM)
RECRUITING

Berlin, 10117, Germany
Chiba University Hospital
RECRUITING

Chiba, Chiba, 260-8677, Japan
Christie Hospital Nhs Trust
RECRUITING

Manchester Withington, M20 4BX, United Kingdom
Chu Hotel Dieu
RECRUITING

Nantes, 44093, France
City Of Hope
RECRUITING

Duarte, California, 91010, United States
Cleveland Clinic Foundation
RECRUITING

Cleveland, Ohio, 44195, United States
Clinica Universidad de Navarra
RECRUITING

Pamplona, 31008, Spain
Colorado Blood Cancer Institute
RECRUITING

Denver, Colorado, 80218, United States
Columbia University Medical Center/New York-Presbyterian Hospital
RECRUITING

New York, New York, 10032, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27705, United States
Erasmus Medical Center - Daniel den Hoed
RECRUITING

Rotterdam, 3075 EA, Netherlands
Fiona Stanley Hospital
RECRUITING

Murdoch, Western Australia, 6150, Australia
Fondazione IRCCS Istituto Nazionale dei Tumori
RECRUITING

Milan, 20133, Italy
Fondazione Monza e Brianza per il Bambino e la sua Mamma (MBBM)
RECRUITING

Monza, 20900, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Universita Cattolica del Sacro Cuore
RECRUITING

Roma, 00168, Italy
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Franciscan Health Indianapolis
RECRUITING

Indianapolis, Indiana, 46237, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Froedtert Hospital BMT Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Gustave Roussy
RECRUITING

Villejuif, 94805, France
H. Lee Moffitt Cancer Center and Research Institute University of South Florida
RECRUITING

Tampa, Florida, 33612, United States
Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Hadassah Medical Center - Ein Kerem Hospital
RECRUITING

Jerusalem, 9112001, Israel
Helsinki University Central Hospital (HUCH)
RECRUITING

Helsinki, 00290, Finland
Hematology and Oncology Associates of SC, LLC
RECRUITING

Greenville, South Carolina, 29615, United States
Hokkaido University Hospital
RECRUITING

Sapporo, Hokkaido, 0608648, Japan
Hopital Henri Mondor
RECRUITING

Creteil-Paris, 94000, France
Hopital Saint Louis
RECRUITING

Paris, 75010, France
Hopital Sud
RECRUITING

Rennes, 35000, France
Hospital 12 De Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Infantil Universitario Nino Jesus
RECRUITING

Madrid, 28009, Spain
Hospital Regional Universitario de Malaga (Antiguo Carlos Haya)
RECRUITING

Málaga, 29010, Spain
Hospital Saint Louis
RECRUITING

Paris, 75475, France
Hospital Universitari Germans Trias i Pujol ICO Badalona
RECRUITING

Barcelona, 08916, Spain
Hospital Universitario Reina Sofia
RECRUITING

Córdoba, 14004, Spain
Hospital Universitario Vall D hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca
RECRUITING

Salamanca, 37007, Spain
Hospital Virgen Del Rocio
RECRUITING

Seville, 41013, Spain
Hôpitaux Universitaires Pitie Salpêtrière Charles Foix
RECRUITING

Paris, 75013, France
IN Univ Simon Cancer Center
RECRUITING

Indianapolis, Indiana, 46202, United States
Icahn School Of Medicine At Mount Sinai
RECRUITING

New York, New York, 10029, United States
Inselspital Bern
RECRUITING

Bern, 3010, Switzerland
Institut Clinic de Nefrologia i Urologia - Hospital Clinic i Provincial de Barcelona
RECRUITING

Barcelona, 8036, Spain
Institut Universitaire du Cancer de Toulouse - Oncopole
RECRUITING

Toulouse, 31059, France
Instituto De Investigacion Marques De Valdecilla (IDIVAL)
RECRUITING

Santander, 39008, Spain
Institutul Clinic Fundeni
RECRUITING

Bucharest, 22328, Romania
Instytut Hematologii I Transfuzjologii
RECRUITING

Warsaw, 02-776, Poland
Intermountain Healthcare - LDS Hospital
RECRUITING

Salt Lake City, Utah, 84143, United States
Istituto Clinico Humanitas
RECRUITING

Rozzano (MI), 20089, Italy
Istituto Nazionale Per Lo Studio E La Cura Dei Tumori Fondazione Giovanni Pascale
RECRUITING

Naples, 80131, Italy
Japan Red Cross Medical Center
RECRUITING

Shibuya-ku, 150-8935, Japan
Jichi Medical University Hospital
RECRUITING

Shimotsuke, Tochigi, 329-0498, Japan
Jules Bordet Institut
RECRUITING

Anderlecht, 1070, Belgium
Kansas University Medical Center
RECRUITING

Westwood, Kansas, 66205, United States
Karmanos Cancer Center Wayne State University
RECRUITING

Detroit, Michigan, 48201, United States
Karolinska University Hospital Huddinge
RECRUITING

Stockholm, 14186, Sweden
Kings College Hospital
RECRUITING

London, SE5 9RS, United Kingdom
Kinikum der Universitaeat zu Koeln
RECRUITING

Cologne, 50937, Germany
Kyushu University Hospital
RECRUITING

Fukuoka, 812-8582, Japan
LMU Klinikum der Universität
RECRUITING

München, 81377, Germany
Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28204, United States
Local Institution - 01020
COMPLETED

Indianapolis, Indiana, 46237, United States
Local Institution - 01021
WITHDRAWN

Tucson, Arizona, 85724, United States
Local Institution - 01023
WITHDRAWN

Richmond, Virginia, 23298, United States
Local Institution - 01026
WITHDRAWN

New Orleans, Louisiana, 70112, United States
Local Institution - 01030
COMPLETED

East Brunswick, New Jersey, 08816, United States
Local Institution - 01033
WITHDRAWN

Temple, Texas, 76508, United States
Local Institution - 01035
COMPLETED

Orlando, Florida, 32804, United States
Local Institution - 01039
COMPLETED

Scottsdale, Arizona, 85258, United States
Local Institution - 01040
WITHDRAWN

Maywood, Illinois, 60153, United States
Local Institution - 01043
WITHDRAWN

Sacramento, California, 95816, United States
Local Institution - 01045
COMPLETED

Norfolk, Virginia, 23502, United States
Local Institution - 01050
WITHDRAWN

Washington D.C., District of Columbia, 20007, United States
Local Institution - 01051
WITHDRAWN

Rochester, New York, 14642, United States
Local Institution - 01053
WITHDRAWN

New Brunswick, New Jersey, 08903, United States
Local Institution - 01054
COMPLETED

Tyler, Texas, 75702, United States
Local Institution - 01055
WITHDRAWN

Tacoma, Washington, 98405, United States
Local Institution - 01056
COMPLETED

Southfield, Michigan, 48075, United States
Local Institution - 01060
WITHDRAWN

Seattle, Washington, 98105, United States
Local Institution - 01061
COMPLETED

Philadelphia, Pennsylvania, 19104, United States
Local Institution - 01063
WITHDRAWN

Niles, Illinois, 60714, United States
Local Institution - 01064
WITHDRAWN

Sioux Falls, South Dakota, 57105, United States
Local Institution - 01066
WITHDRAWN

New York, New York, 10016, United States
Local Institution - 01069
NOT_YET_RECRUITING

Wauwatosa, Wisconsin, 53226, United States
Local Institution - 01106
WITHDRAWN

Boston, Massachusetts, 02115, United States
Local Institution - 01107
WITHDRAWN

Boston, Massachusetts, 02114, United States
Local Institution - 01114
COMPLETED

Bethesda, Maryland, 20892-1203, United States
Local Institution - 01206
WITHDRAWN

Los Angeles, California, 90048, United States
Local Institution - 02801
WITHDRAWN

Hamilton, Ontario, L8V 1C3, Canada
Local Institution - 02802
WITHDRAWN

Vancouver, British Columbia, V5Z 1M9, Canada
Local Institution - 03155
NOT_YET_RECRUITING

Berlin, 13353, Germany
Local Institution - 03454
WITHDRAWN

Münster, 48149, Germany
Local Institution - 03500
WITHDRAWN

Frankfurt, 60590, Germany
Local Institution - 03503
COMPLETED

Tübingen, 72076, Germany
Local Institution - 03513
WITHDRAWN

Düsseldorf, 40225, Germany
Local Institution - 04400
WITHDRAWN

Utrecht, 3584 CS, Netherlands
Local Institution - 04650
COMPLETED

Amsterdam, 1081 HV, Netherlands
Local Institution - 05200
WITHDRAWN

Ghent, 9000, Belgium
Local Institution - 07500
WITHDRAWN

Roma, 00168, Italy
Local Institution - 07610
COMPLETED

Torino, 01012, Italy
Local Institution - 08251
COMPLETED

Esplugues de Llobregat, 08950, Spain
Local Institution - 09400
COMPLETED

Marseille, 13009, France
Local Institution - 09600
WITHDRAWN

Paris, 75935, France
Local Institution - 09601
WITHDRAWN

Lyon, 69008, France
Local Institution - 09602
WITHDRAWN

Marseille, 13385, France
Local Institution - 10850
WITHDRAWN

Leeds, LS9 7TF, United Kingdom
Local Institution - 13202
COMPLETED

Bunkyō City, 113-8677, Japan
Local Institution - 13804
WITHDRAWN

Shinjuku, 162-8666, Japan
Local Institution - 20003
NOT_YET_RECRUITING

Aarhus, 8200, Denmark
Local Institution - UNK 2
WITHDRAWN

Leuven, B-3000, Belgium
M Health Fairview University of Minnesota Medical Center - East Bank
RECRUITING

Minneapolis, Minnesota, 55455, United States
Massachusetts General Hospital / Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic Phoenix
RECRUITING

Phoenix, Arizona, 85054, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Morristown Memorial Hosp
RECRUITING

Morristown, New Jersey, 07962, United States
Nagoya City University Hospital
RECRUITING

Nagoya, 467-8602, Japan
National Cancer Center Hospital
RECRUITING

Chuo-ku, Tokyo, 1040045, Japan
National Hospital Organization Okayama Medical Center
RECRUITING

Okayama, 701-1192, Japan
New York Oncology Hematology P.C.
RECRUITING

Albany, New York, 12206, United States
New York University - Langone Medical Center - The Center for Musculoskeletal Care
RECRUITING

New York, New York, 10016, United States
Northside Hospital, Inc
RECRUITING

Atlanta, Georgia, 30342, United States
Northwestern Memorial Hospital
RECRUITING

Chicago, Illinois, 60611, United States
Norton Cancer Institute Louisville Oncology
RECRUITING

Louisville, Kentucky, 40207, United States
Novant Health
RECRUITING

Salisbury, North Carolina, 28147, United States
Odense University Hospital
RECRUITING

Odense, 5000, Denmark
Ohio State University Comprehensive Cancer Center (OSUCCC) - The James Cancer Hospital and Solove Research Institute
RECRUITING

Columbus, Ohio, 43210, United States
Oncology Hematology Care, Inc.
RECRUITING

Cincinnati, Ohio, 45242, United States
Ordensklinikum Linz GmbH Elisabethinen
RECRUITING

Linz, 4020, Austria
Oregon Health and Science University OHSU
RECRUITING

Portland, Oregon, 97239, United States
Osaka Metropolitan university Hospital
RECRUITING

Osaka, 545-8586, Japan
Osaka Red Cross Hospital
RECRUITING

Tennoji-Ku, Osaka, 543-8555, Japan
Oslo Universitetssykehus
RECRUITING

Oslo, 0310, Norway
Ospedale Pediatrico Bambino Gesu
RECRUITING

Rome, 00165, Italy
Ospedali Riuniti di Ancona
RECRUITING

Ancona, 60126, Italy
Otto-von-Guericke-Universitaet Magdeburg - Universitaetsklinikum Magdeburg A.Oe.R - Universitaetskli
RECRUITING

Magdeburg, 39120, Germany
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, Victoria, 3000, Australia
Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States
Robert-Rossle-Klinik im HELIOS Klinikum Berlin-Buch Klinik fur Hamatologie, Onkologie u. Tumorimmuno
RECRUITING

Berlin, 13125, Germany
Roskilde Sygehus
RECRUITING

Roskilde, Region Sjælland, 4000, Denmark
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States
Royal Prince Alfred Hospital
RECRUITING

Camperdown, New South Wales, 2050, Australia
Sam Clinical Research Center
RECRUITING

San Antonio, Texas, 78229, United States
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Sarah Cannon Research Inst
RECRUITING

Nashville, Tennessee, 37203, United States
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Sidney Kimmel Comp Cancer Center at Johns Hopkins
RECRUITING

Baltimore, Maryland, 21231, United States
Siteman Cancer Center
RECRUITING

St Louis, Missouri, 63110, United States
Somers Cancer Research Building
RECRUITING

Shirley Southampton, SO16 6YD, United Kingdom
Soroka Medical Center
RECRUITING

Beersheba, Southern District, 85025, Israel
St Johns Cancer Centre in Lublin
RECRUITING

Lublin, 20-090, Poland
Stanford Cancer Center
RECRUITING

Stanford, California, 94305, United States
Swedish Cancer Institute
RECRUITING

Seattle, Washington, 98104, United States
Sylvester Comprehensive Cancer Center, University of Miami Hospital and Clinics
RECRUITING

Miami, Florida, 33136, United States
Tel-Aviv Sourasky Medical Center
RECRUITING

Tel Aviv, 6423906, Israel
Texas Oncology
RECRUITING

Dallas, Texas, 75230, United States
Texas Oncology - Baylor Charles A. Sammons Cancer Center
RECRUITING

Dallas, Texas, 75246, United States
The Alfred Hospital
RECRUITING

Melbourne, Victoria, 3004, Australia
The Catholic University of Korea, Seoul St. Mary's Hospital
RECRUITING

Seoul, 6591, South Korea
The Chaim Sheba Medical Center
RECRUITING

Tel Litwinsky, 5262100, Israel
The Mayo Clinic - Jacksonville, Davis-E
RECRUITING

Jacksonville, Florida, 32224, United States
The University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States
The University of Texas Health Science Center at Houston
RECRUITING

Houston, Texas, 77030, United States
Thomas Jefferson University - Clinical Research Institute
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Tokai University Hospital
RECRUITING

Isehara City, Kanagawa, 259-1193, Japan
Toranomon Hospital
RECRUITING

Minato-ku, Tokyo, 105-8470, Japan
Turku University Hospital
RECRUITING

Turku, 20520, Finland
UCL Cancer Institute
RECRUITING

London, WC1E 6BT, United Kingdom
UCLA Medical Centre-Santa Monica
RECRUITING

Santa Monica, California, 90095, United States
UPMC Cancer Pavillion
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
USF Health Morsani Center for Advanced Healthcare
RECRUITING

Tampa, Florida, 33606, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
Universitaetsklinikum Duesseldorf
RECRUITING

Düsseldorf, 40225, Germany
Universitaetsklinikum Essen
RECRUITING

Essen, 45147, Germany
Universitaetsklinikum Hamburg-Eppendorf
RECRUITING

Hamburg, 20426, Germany
Universitair Ziekenhuis Brussel
RECRUITING

Brussels, 1090, Belgium
Universitatsklinikum Carl Gustav Carus an der TU Dresden
RECRUITING

Dresden, D-01307, Germany
Universitatsklinikum Heidelberg
RECRUITING

Heidelberg, 69120, Germany
Universitatsklinikum Wurzburg Medizinische Klinik und Poliklinik II
RECRUITING

Würzburg, 97080, Germany
University General Hospital of Patras
RECRUITING

Rio Patras, 26504, Greece
University Hospital Leuven
RECRUITING

Leuven, 3000, Belgium
University Hospital of Ulm
RECRUITING

Ulm, 89081, Germany
University Hospital,Kyoto Prefectural University of Medicine
RECRUITING

Kyoto, 602-8566, Japan
University Hospitals of Cleveland
RECRUITING

Cleveland, Ohio, 44106-5000, United States
University Of Calgary
RECRUITING

Calgary, Alberta, T2N 2T9, Canada
University Of California San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92093, United States
University Of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637-1447, United States
University Of Colorado Cancer Center
RECRUITING

Aurora, Colorado, 80045, United States
University Of Kentucky
RECRUITING

Lexington, Kentucky, 40536, United States
University Of Michigan Comprehensive Cancer Center
RECRUITING

Ann Arbor, Michigan, 48109, United States
University Of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198-6840, United States
University Of Virginia Health System
RECRUITING

Charlottesville, Virginia, 22903, United States
University Of Wisconsin
RECRUITING

Madison, Wisconsin, 53705, United States
University of Alabama Birmingham
RECRUITING

Birmingham, Alabama, 10016, United States
University of California, San Francisco- California
RECRUITING

San Francisco, California, 94143, United States
University of Maryland - Greenebaum Comprehensive Cancer Center
RECRUITING

Baltimore, Maryland, 21201, United States
University of Massachusetts Memorial Medical Center
RECRUITING

North Worcester, Massachusetts, 01655, United States
University of Oklahoma Peggy and Charles Stephenson Cancer Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Pennsylvania Perelman Center for Advanced Medicine
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Texas- MD Anderson
RECRUITING

Houston, Texas, 77030, United States
University of Utah - Huntsman Cancer Institute
RECRUITING

Salt Lake City, Utah, 84112, United States
Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, 80-214, Poland
Uz Gent
RECRUITING

Ghent, 9000, Belgium
Weill Cornell Medicine / New York Presbyterian Hospital
RECRUITING

New York, New York, 10021, United States
Willamette Valley Cancer Institute
RECRUITING

Eugene, Oregon, 97401, United States
Winship Cancer Institute of Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Yale Cancer Center
RECRUITING

New Haven, Connecticut, 06520, United States

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