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Long COVID exercise breakthrough? new study tests ways to boost energy

NCT ID NCT06404047

Symptom relief Sponsor: Duke University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested different treatments to help people with Long COVID who struggle with exercise and feel very tired after activity. Researchers enrolled 660 adults across multiple medical centers to see if these treatments could improve exercise ability, daily activity, and quality of life. The goal is to find practical ways to help people feel better and do more.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

660 people

The number who actually took part.

Started

Jul 2024

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. ≥ 18 years of age at the time of enrollment 2. Previous suspected, probable, or confirmed SARS-CoV-2 infection, as defined by the Pan American Health Organization\* * Suspected\* or probable SARS-CoV-2 infection will only be allowed if it occurred before May 1, 2021, and will be limited to no more than 10% of the study population. Otherwise, confirmed cases are required. Suspected case of SARS-CoV-2 infection - Three options, A through C: A. A person who meets the clinical OR epidemiological criteria. Clinical criteria: Acute onset of fever AND cough (influenza-like illness) OR Acute onset of ANY THREE OR MORE of the following signs or symptoms: fever, cough, general, weakness/fatigue, headache, myalgia, sore throat, coryza, dyspnea, nausea, diarrhea, anorexia. Epidemiological criteria: Contact of a probable or confirmed case or linked to a COVID-19 cluster; or B. Acute respiratory infection with history of fever or measured fever of ≥ 38°C; and cough; with onset within the last 10 days; and who requires hospitalization; or C. With no clinical signs or symptoms, NOR meeting epidemiologic criteria with a positive professional use or self-test SARS-CoV-2 Antigen-Rapid Diagnostic Test. Probable case of SARS-CoV-2 infection: A. A patient who meets clinical criteria above AND is a contact of a probable or confirmed case or is linked to a COVID-19 cluster. Confirmed case of SARS-CoV-2 infection - Two options, A and B: A. A person with a positive nucleic acid amplification test, regardless of clinical criteria OR epidemiological criteria; or B. Meeting clinical criteria AND/OR epidemiological criteria (See suspected case A above for criteria). With a positive professional use or self-test SARS- CoV-2 Antigen-Rapid Diagnostic Test. 3. Self-reported limitation to physical activity due to the presence of symptoms such as fatigue, shortness of breath, and/or PEM following a SARS-CoV-2 infection, that has persisted for at least 12 weeks and is present at the time of consent. 4. Willing, able, and agree to provide informed consent, complete questionnaires and outcome assessments, and participate in the study, including assigned intervention or control and study visits whether remote, hybrid, or in-person. Exclusion Criteria: An individual who meets any of the following criteria will be excluded from participation in this study: 1. Known active acute SARS-CoV-2 infection ≤ 4 weeks prior to the consent. 2. Known prior diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), not related to SARS-CoV-2 infection. 3. Current or recent use (within the last 14 days) of a formal program utilizing one or more of the current study intervention(s) or similar intervention(s) to treat the underlying condition, unless a washout period is permitted per Appendices. 4. Participation in another interventional clinical trial. 5. Any condition that would make the participant, in the opinion of the investigator, unsuitable for the study.

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Conditions

The condition(s) this trial relates to.

long COVID-19 Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Long COVID Long COVID-19 Long COVID19

Contacts and locations

Locations

  • Avera McKennan Hospital & University Health Center

    Sioux Falls, South Dakota, 57108, United States

  • Banner University Medical Center Phoenix

    Phoenix, Arizona, 85006, United States

  • Banner University Medical Center Tucson

    Tucson, Arizona, 85719, United States

  • Beth Israel Deaconess Med. Ctr.

    Boston, Massachusetts, 02215, United States

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • Cedar Valley Clinical Research

    Waterloo, Iowa, 50701, United States

  • Dartmouth Hitchcock Medical Center

    Lebanon, New Hampshire, 03756, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Emory Hope Clinic

    Decatur, Georgia, 30030, United States

  • Grady Memorial Hospital (Emory)

    Atlanta, Georgia, 30303, United States

  • Henry Ford Hospital

    Detroit, Michigan, 48202, United States

  • Houston Methodist Hospital

    Houston, Texas, 77030, United States

  • Innovation Clinical Trials Inc.

    Miami, Florida, 33144, United States

  • Kansas University Medical Center

    Kansas City, Kansas, 66160, United States

  • Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center

    Torrance, California, 90509, United States

  • Maine Health Institute of Research

    Scarborough, Maine, 04074, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • NYU Langone Health/Brooklyn Hospital

    Brooklyn, New York, 11220, United States

  • North Shore University HealthSystem/Evanston Hospital

    Evanston, Illinois, 60201, United States

  • Oregon Health and Science University

    Portland, Oregon, 97239-3098, United States

  • Rush University Medical Center

    Chicago, Illinois, 60612, United States

  • Saint Francis Medical Center

    Peoria, Illinois, 61637, United States

  • Southwest Family Medicine Associates

    Dallas, Texas, 75235, United States

  • Stanford University

    Stanford, California, 94035, United States

  • Tufts Medical Center

    Boston, Massachusetts, 02111, United States

  • University Physicians and Surgeons, Inc dba Marshall Health

    Huntington, West Virginia, 25701, United States

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35205, United States

  • University of Colorado

    Aurora, Colorado, 80045, United States

  • University of Florida College of Medicine Jacksonville

    Jacksonville, Florida, 32209, United States

  • University of Illinois at Chicago

    Chicago, Illinois, 60608, United States

  • University of Kentucky

    Lexington, Kentucky, 40536, United States

  • University of New Mexico Health Sciences Center

    Albuquerque, New Mexico, 87102, United States

  • University of North Carolina Hospital

    Chapel Hill, North Carolina, 27514, United States

  • University of Pittsburgh

    Pittsburgh, Pennsylvania, 15213, United States

  • University of Texas Health Science Center at Houston

    Houston, Texas, 77030, United States

  • University of Utah

    Salt Lake City, Utah, 84132, United States

  • Valencia Medical and Research Center

    Miami, Florida, 33165, United States

  • Vermont Lung Center, University of Vermont

    Colchester, Vermont, 05446, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • West Virginia Clinical and Translational Science Institute

    Morgantown, West Virginia, 26506, United States

  • Yale - New Haven Hospital

    New Haven, Connecticut, 06520-8017, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.