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Do childhood infections shape a lifetime of immunity?

NCT ID NCT02654210

NEW Knowledge-focused Sponsor: Helmholtz Centre for Infection Research Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 21, 2026 · Last updated Sep 21, 2026

Summary

Researchers follow newborns in a German region to see how infections, the microbiome, and vaccinations interact as children's immune systems develop. The study tracks health data over time to understand why some children develop allergies or asthma. It aims to reveal patterns that could guide future prevention strategies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If researchers can map how infections and vaccinations shape immunity, this could inform strategies to prevent allergies and asthma in children.
What could go wrong
This is an observational birth cohort, so it can reveal patterns but cannot prove cause and effect. Findings may not apply to children outside the study region.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

782 people

The number who actually took part.

Started

Mar 2015

Expected to finish

Feb 2033

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Healthy Newborns in the Studyregions: Braunschweig, Hannover, Bremen, München, Halle (Saale), Germany

Ages

1 day to 3 months

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * newborn in a study region Exclusion Criteria: * parents \< 18 years old * insufficient knowledge of the German language (parents)

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Conditions

The condition(s) this trial relates to.

infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Infectious diseases

Contacts and locations

Locations

  • Helmholtz Centre for Infection Research

    Braunschweig, Lower Saxony, 38124, Germany

  • Martin-Luther-University Halle-Wittenberg

    Halle, Saxony-Anhalt, 06112, Germany

More trials for these conditions

Other studies related to the condition(s) this trial covers.