Liquid metformin: easier swallowing or just different?
NCT ID NCT07300020
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how a new liquid version of metformin (a common diabetes medicine) is absorbed by the body compared to regular tablets. Twenty-four healthy adults will take both forms in a random order, with blood tests to measure drug levels. The goal is to see if the liquid works similarly to the tablet, not to treat any disease.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
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About 24 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Apr 2026
An estimate. Start dates often move.
- Expected to finish
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Jun 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 55 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male or female adults 18 to 55 years of age, inclusive. Body mass index (BMI) between 18.0 and 30.0 kg/m², inclusive. Medically healthy based on medical history, physical examination, vital signs, 12-lead ECG, and clinical laboratory tests, in the opinion of the investigator. Non-smoker or light smoker (10 or fewer cigarettes per day or equivalent) willing to abstain from smoking during confinement periods, as determined by the investigator. Able to understand and provide written informed consent before any study-specific procedures are performed. Willing and able to comply with all study requirements, including fasting requirements, visit schedules, and pharmacokinetic blood sampling. Females of childbearing potential must use acceptable contraception as determined by the investigator. Exclusion Criteria: * Known hypersensitivity or contraindication to metformin or any component of the study formulations. History or presence of any clinically significant cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, hematologic, neurologic, or psychiatric disease that, in the opinion of the investigator, could interfere with study participation or interpretation of results. Estimated glomerular filtration rate (eGFR) less than 90 mL/min/1.73 m², or any clinically significant abnormality in clinical laboratory tests. History of lactic acidosis. Use of any prescription or over-the-counter medications, herbal products, or dietary supplements within 14 days before the first study dose, unless considered acceptable by the investigator. Positive test for hepatitis B surface antigen, hepatitis C antibody, or HIV. Positive urine drug screen or positive alcohol breath test at screening or at admission to the clinical unit. Participation in another clinical trial or receipt of an investigational drug or device within 30 days or 5 half-lives of the prior investigational product (whichever is longer) before the first study dose. Donation of 450 mL or more of blood, or significant blood loss, within 8 weeks before the first study dose. Pregnant or breastfeeding females. Women of childbearing potential not using acceptable methods of contraception. Any condition or circumstance that, in the opinion of the investigator, would make the subject unsuitable for the study.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
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