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New study explores hidden metabolic differences between lipedema and obesity

NCT ID NCT07240298

Knowledge-focused Sponsor: Istanbul Physical Medicine Rehabilitation Training and Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 140 women to compare metabolic risk markers—like insulin resistance and cholesterol ratios—between those with lipedema and those with obesity. Researchers used existing blood test results to calculate these markers without any new treatments or interventions. The goal is to better understand how lipedema affects metabolic health compared to regular obesity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If this study finds clear differences, it could help doctors better distinguish lipedema from obesity and guide future research on metabolic risks.
What could go wrong
This is a small, completed observational study using existing data, so it cannot prove cause and effect. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

140 people

The number who actually took part.

Started

Oct 2025

Finished

Nov 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

obese patients with and without lipedema

Ages

18 to 75 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Clinically diagnosed with lipedema * Obese control group with BMI ≥30 kg/m² who do not meet lipedema criteria * Aged between 18 and 75 years * Availability of fasting lipid profile and fasting glucose tests within the past 3 months * Provided voluntary informed consent Exclusion Criteria: * Use of medications that routinely affect lipid or glucose metabolism: statins, fibrates, niacin, ezetimibe, high-dose omega-3 supplements, GLP-1 receptor agonists, SGLT2 inhibitors, or systemic corticosteroids (regular use within the past 3 months) * Presence of rheumatologic diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) or active malignancy * Neurological disorders (e.g., polyneuropathy, multiple sclerosis, history of stroke) * Pregnancy or lactation * History of lower extremity surgery or major trauma within the past 6 months * Received injection therapy or physical therapy for the lower extremities within the past 6 months * Active infection or dermatological disease affecting the lower extremities * History of significant venous insufficiency or acute deep vein thrombosis (DVT) * Alcohol or substance abuse * Smoking

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Conditions

The condition(s) this trial relates to.

Lipedema obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lipedema

Contacts and locations

Locations

  • Istanbul Physical Medicine Rehabilitation Training and Research Hospital

    Istanbul, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.