Herbal extract may ease the toll of lung cancer immunotherapy
NCT ID NCT04348149
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This pilot study tests whether a daily herbal supplement made from Lindera obtusiloba can improve quality of life for people with non-small cell lung cancer who are receiving PD-1 or PD-L1 inhibitor immunotherapy. About 20 adults will take the supplement for 8 weeks alongside their usual treatment. Researchers will measure changes in quality of life, lung cancer symptoms, and immune cell levels to see if the supplement offers any benefit.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Lindera obtusiloba extract (a herbal dietary supplement)
- What this could lead to
- If effective, this herbal supplement could offer a natural way to improve quality of life and reduce symptoms for lung cancer patients undergoing immunotherapy.
- What could go wrong
- This is a small pilot study with only 20 participants, so results may not be conclusive. The supplement's safety and effectiveness are not yet established, and it may not provide significant benefits.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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20 people
The number who actually took part.
- Started
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Dec 2018
- Finished
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Dec 2020
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults aged ≥ 20 years * Patients who have understood and signed the informed consent. * Subjects who have been confirmed histologically and radiologically for non small cell lung cancer and are scheduled to receive treatment with immune checkpoint inhibitors * Subjects whose urine HCG are negative and who have agreed with the appropriate method of contraception in case of women of childbearing potential * Subjects who can fully communicate with their medical doctor about their symptoms or quality of life and who can fill out questionnaires * Subjects who can follow up during the clinical trial * Eastern Cooperative Oncology Group (ECOG) performance status score ≤ 2 * Hemoglobin ≥ 9g/dL Exclusion Criteria: * Subjects who are pregnant, breastfeeding, planning to become pregnant or women of childbearing potential who do not agree with the appropriate method of contraception * Subjects who have symptomatic and uncontrolled brain or central nervous system metastasis * Subjects who complain of uncontrolled pain despite using analgesics * Diastolic Blood Pressure\>100mmHg or Systolic Blood Pressure\>160mmHg * Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels higher than 2.5 times the upper limit for normal * Creatinine level higher than 1.5 times the upper limit for normal * Subjects who have participated in other clinical trials within 1 months * Subjects with a history of serious drug allergies or who have hypersensitivity to the Investigational Product (the main ingredient and its components) * Subjects with autoimmune diseases * Subjects who have alcoholism or drug dependence * Subjects who have cognitive impairment or psychiatric problems * Subjects who have undergone surgery within 2 weeks * Subjects who took other herbal medicine or other medicines within 4 weeks * Subjects who have a medical condition that is likely to affect results or who are determined to be inappropriate to participate in this clinical trial at the investigator
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Korean Medicine Hospital, Pusan National University
Yangsan, Gyeongsangnam-do, 50612, South Korea
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Other studies related to the condition(s) this trial covers.
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