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A beam of light to the brain: could it ward off Post-Surgery fog?

NCT ID NCT07736092

Disease control Sponsor: Peking University First Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 30, 2026 · Last updated Aug 11, 2026 · Updated 3 times

Summary

This trial tests whether shining a special near-infrared light on the forehead — a technique called transcranial photobiomodulation — can reduce the risk of delayed neurocognitive recovery (a form of brain fog) in older adults after surgery. The study includes people aged 65 and older who already have mild memory or thinking problems and are scheduled for non-cardiac, non-brain surgery. Participants receive either the real light treatment or a fake version before and after surgery to see if the light helps protect their cognitive function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a device that shines near-infrared light on the forehead
What this could lead to
If it works, this could offer a simple, non-drug way to protect older adults' thinking skills after surgery.
What could go wrong
This is a small, early-stage trial. The light therapy may not work better than a fake treatment, and its effects on the brain are still uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 130 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2026

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 65 years or older. * Preoperative Mini-Mental State Examination (MMSE) \<27. * Scheduled to undergo non-cardiac, non-neurosurgical surgery under general anesthesia, with an expected surgical duration \>1 hour. * Planned hospital stay of at least 1 day before surgery and at least 2 days after surgery. Exclusion Criteria: * Communication barriers before surgery due to coma, severe dementia, or language disorders. * History of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis, or delirium before surgery. * History of brain injury, tumors, or surgery, or intracranial metal implants, or skin or soft tissue injuries on the head or face. * History of ischemic or hemorrhagic stroke within 3 months before surgery. * An American Society of Anesthesiologists class ≥ IV. * Enrolled in other interventional studies. * Other conditions deemed unsuitable for study participation.

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Conditions

The condition(s) this trial relates to.

Emergence Delirium

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Delayed neurocognitive recovery Older adults Postoperative delirium Surgery Transcranial photobiomodulation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Peking University First Hospital

    RECRUITING

    Beijing, Beijing Municipality, 100034, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.