Sound waves against binge eating: new brain zap trial launches

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Males and non-pregnant females, 22 - 65 years of age. * Participant meets DSM-5 criteria for moderate to extreme BED. * Weight ≤450lb to accommodate in MRI. * Shoulder width of ≤65 inches to accommodate in MRI. * The neuromodulation targets are visible on MRI for target selection. * Participant is able and willing to give informed consent. Exclusion Criteria: * Unable to undergo MR-imaging because of implanted pacemakers, medication pumps, aneurysm clips, metallic prostheses (including metal pins and rods, heart valves or cochlear implants), shrapnel fragments, permanent make-up or small metal fragments in the eye that welders and other metal workers may have, or if candidates are uncomfortable in small spaces (have claustrophobia). * Participants with more than 30% of the skull area traversed by the sonication pathway are covered by scars, scalp disorders (e.g., eczema), atrophy of the scalp, or implanted objects in the skull or the brain. * Participants with known untreated or unstable cardiac status or hypertension * Evidence of substance (alcohol or other drug) use disorder during the previous 12 months (assessed via SCID-5). * Past or present diagnosis of schizophrenia, psychotic disorder or bipolar disorder (assessed via SCID-5) * Participant who is currently participating in another clinical investigation with an active treatment arm. * Use of any medications that, in the opinion of the Investigator, may put the participant at higher risk for AEs, or impair the participant's ability to perform complete study procedures. * Participant is considered to be a poor surgical or study candidate, which may include, but is not limited to the following: any medical, social, or psychological problem that could complicate the required procedures and evaluations of the study in the judgment of the investigator. * Participant is pregnant/lactating or planning to be pregnant.