Could a simple inhaled drug during surgery prevent dangerous lung complications?
NCT ID NCT07000760
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether giving lidocaine as a mist into the lungs during major abdominal surgery could lower the chance of serious lung problems after the operation. Lung complications after surgery can lengthen hospital stays and increase costs and death risk. The study included 270 adults having planned major non-cardiac surgery under general anesthesia. The key approach was to use lidocaine's anti-inflammatory effects to protect the lungs.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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270 people
The number who actually took part.
- Started
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Jun 2025
- Finished
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Jan 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 90 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients who have signed the informed consent form and are willing to complete the study according to the protocol * Age ≥18 years old and ≤90 years old * ASA classification grades I-III * Elective major non-cardiac surgery * General anesthesia under tracheal intubation * Monitor invasive arterial blood pressure * The expected operation time ≥2 hours Exclusion Criteria: * Untreated ischemic heart disease Severe cardiovascular and cerebrovascular diseases * Severe asthma, pulmonary bullae, pneumothorax, bronchopleural fistula, etc * Severe underlying liver and kidney diseases * Age under 18 years old or over 90 years old * The expected operation time is ≥2 hours
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Fudan University Shanghai Cancer Center
Shanghai, China
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Fudan University Shanghai Cancer Centre
Shanghai, Shanghai Municipality, 200032, China
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Other studies related to the condition(s) this trial covers.
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