New hope for stuffy noses: drug trial targets nasal polyps

NCT ID NCT06338995

Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Sep 09, 2026 · Updated 10 times

Summary

This study tests an investigational drug called lebrikizumab in people with long-term sinus inflammation and nasal polyps. About 510 adults will receive either the drug or a placebo, while all continue using standard steroid nasal sprays. The goal is to see if the drug can improve nasal congestion and shrink polyps over 18 months.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 510 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2024

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Physician-diagnosed chronic rhinosinusitis (CRS) with bilateral nasal polyps (NP). * Prior treatment with systemic corticosteroids (SCS) within the last 2 years (or a medical contraindication or intolerance to SCS), prior surgery for NP, or both. * Endoscopic bilateral NPS score of at least 5 out of 8, with a minimum score of 2 in each nasal cavity performed at screening and baseline. * Ongoing symptoms for at least 8 weeks prior to study entry (screening), including: 1. Nasal congestion with moderate or severe symptom severity (score 2 or 3) at screening and a weekly average severity score of at least 1 (range 0 to 3) at randomization, and 2. At least one other symptom, such as partial loss of smell (hyposmia), total loss of smell (anosmia), or anterior or posterior rhinorrhea. * Have concomitant asthma must be stable in the 3 months prior to screening using permitted regular asthma treatment. * Adolescent participants ≥12 to \<18 years of age and weighing ≥40 kg at time of Visit 1. Exclusion Criteria: * Have received a dose of lebrikizumab. * Have received treatment with any rescue medication and/or have the need for surgery for NP during screening and/or run-in period. * Allergen immunotherapy (subcutaneous immunotherapy \[SCIT\]/sublingual immunotherapy \[SLIT\]) initiated within 6 months prior to screening, that is not on a stable dose (3 months prior to screening). * Has received a biologic treatment approved for use in CRSwNP, asthma, or AD, even if administered to treat a different condition, within 4 months or 5 half-lives, whichever is longer, prior to screening. * Have received treatment with any biologic or systemic immunosuppressants for inflammatory disease or autoimmune disease prior to the baseline visit: 1. B cell-depleting biologics, including rituximab, within 6 months. 2. other biologics within 5 half-lives (if known) or 8 weeks, whichever is longer. 3. Systemic immunosuppressants within 4 weeks prior to baseline. * Have had any sinus intranasal surgery (including nasal polypectomy) within 6 months prior to screening * Have had prior sino-nasal surgery or sinus surgery changing lateral wall structure of the nose making it difficult to assess endoscopic NPS * Have a presence of any of the following conditions that may impact the assessment of endpoints at screening or baseline: 1. Nasal septal deviation occluding at least one nostril. 2. Antrochoanal polyps. 3. Acute sinusitis, acute nasal infection, or acute upper respiratory infection. 4. Ongoing rhinitis medicamentosa. 5. Presence of another diagnosis associated with NP (ie, eosinophilic granulomatosis with polyangiitis, granulomatosis with polyangiitis, Young's syndrome, primary ciliary dyskinesia, cystic fibrosis). Note: for adolescents, documentation for ruling out cystic fibrosis and primary ciliary dyskinesia is required. 6. A nasal cavity tumor (malignant or benign). 7. Evidence of fungal rhinosinusitis. * Have anosmia from COVID or any reason other than CRSwNP. * Participants with forced expiratory volume in 1 second (FEV1) 50% or less (of predicted normal) at screening. * Female participant who is pregnant, breastfeeding, or is planning to become pregnant, or to breastfeed during the study.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic rhinosinusitis with nasal polyps (CRSWNP)

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

202 sites in 20 countries. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

1-8-1, Kishinoura
RECRUITING

Kitakyushu, 806-8501, Japan
3-54-2, Kotohirahommachi
RECRUITING

Kumamoto, 860-0814, Japan
8-2 Otemachi
RECRUITING

Shizuoka, 420-0853, Japan
ADCRC
NOT_YET_RECRUITING

La Mesa, California, 91942, United States
AOU Careggi- University of Florence
RECRUITING

Florence, 50134, Italy
AOU Federico II Via Pansini
RECRUITING

Naples, 80131, Italy
ASST Brianza - Vimercate Hospital
RECRUITING

Vimercate, 20871, Italy
Aalborg Universitetshospital Medicinerhuset Lungemedicinsk Forskningsenhed
RECRUITING

Aalborg, Denmark
Aarhus University Hospital, Dept. of Ear-Nose-Throat
RECRUITING

Aarhus, 8200, Denmark
Ajou University Hospital
RECRUITING

Suwon, 16499, South Korea
Alamo ENT Associates
RECRUITING

San Antonio, Texas, 78258-3227, United States
Alina Clinical Trials
RECRUITING

Dallas, Texas, 75209, United States
AllerVie Clinical Research
NOT_YET_RECRUITING

Birmingham, Alabama, 35209, United States
Ark Clinical Research
NOT_YET_RECRUITING

Long Beach, California, 90815, United States
Asahioka, 1-24
RECRUITING

Niigata, 940-8621, Japan
Avenida Independencia
NOT_YET_RECRUITING

Aguascalientes, 20116, Mexico
Azienda Ospedaliera Di Padova
RECRUITING

Padova, 35128, Italy
Azienda Ospedaliero Universitaria Pisana - Stabilimento Santa Chiara
RECRUITING

Pisa, 56126, Italy
B&R Clinical Sp. z o.o
RECRUITING

Kielce, 25-426, Poland
Beijing Hospital
NOT_YET_RECRUITING

Beijing, 100730, China
Beijing Tongren Hospital
RECRUITING

Beijing, 100730, China
Bioresearch Partner-Kendale Lakes
RECRUITING

Miami, Florida, 33155, United States
Bispebjerg Hospital Department of Respiratory Medicine
NOT_YET_RECRUITING

Copenhagen, Denmark
Breathe Clear Institute
RECRUITING

Torrance, California, 90503, United States
Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02215, United States
Bristol Royal Infirmary University Hospitals
RECRUITING

Bristol, BS2 8HW, United Kingdom
CARE - Centro de Alergia y Enfermedades Respiratorias
RECRUITING

Villa Crespo, C1414AIF, Argentina
CEMLO - Centro de Especialidades Médicas Lobos
RECRUITING

Beunos Aires, B7240KJB, Argentina
CHA Bundang Medical Center
RECRUITING

Gyeonggi-do, 13496, South Korea
CIMER-Centro Integral de Medicina Respiratoria
RECRUITING

San Miguel de Tucumán, Argentina
CSAC
RECRUITING

Québec, Canada
Calle Pascual Orozco #2125 col. Magisterial Universidad
NOT_YET_RECRUITING

Chihuahua City, CP 31200, Mexico
Calle Penitenciaria
RECRUITING

Guadalajara Jalsico, 44100, Mexico
Cardiomed S.R.L
RECRUITING

Cluj-Napoca, 400015, Romania
Centro Clínico Académico - Braga (2CA-Braga) (Hospital de Braga)
RECRUITING

Braga, 4710-243, Portugal
Centro Médico Teknon
RECRUITING

Barcelona, 8022, Spain
Centro Respiratorio Infantil
NOT_YET_RECRUITING

Santa Fe, 2000, Argentina
Centro de Investigaciones Clínicas - IESR - Rosario
RECRUITING

Rosario, CP 2000, Argentina
Centrul Medical De Diagnostic Si Tratament Ambulator Neomed S.R.L
RECRUITING

Brasov, 500450, Romania
Centrul Medical De Diagnostic Si Tratament Ambulator Neomed S.R.L
RECRUITING

Brasov, 500450, Romania
Centrul Medical Unirea SRL
RECRUITING

Brasov, 500091, Romania
Centrul de Excelenta in Rinologie S.R.L
RECRUITING

Dolj, 200222, Romania
Centrum Medyczne All-Med
RECRUITING

Krakow, 30-033, Poland
Centrum Medyczne Angelius Provita
RECRUITING

Katowice, 40-611, Poland
Centrum Medyczne Biotamed Morawska Barbara
RECRUITING

Wieliczka, 32-020, Poland
Centrum Medyczne Oporów
RECRUITING

Wroclaw, 52-416, Poland
Centrum Medyczne Pratia Katowice
RECRUITING

Katowice, 40-081, Poland
Centrum Medyczne Promed ul. Olszańska 5G
RECRUITING

Krakow, 31-513, Poland
Charing Cross Hospital
RECRUITING

Chelsea, W6 8RF, United Kingdom
Charite-Universitatsmedizin Berlin
RECRUITING

Berlin, 10117, Germany
Charleston ENT
NOT_YET_RECRUITING

Charleston, South Carolina, 29406, United States
Chesapeake Clinical Research, Inc.
RECRUITING

White Marsh, Maryland, 21162, United States
Chicago ENT
RECRUITING

Chicago, Illinois, 60657, United States
Circuit Clinical/Mercer Allergy and Pulmonary Associates
NOT_YET_RECRUITING

Hamilton, New Jersey, 08619, United States
Clinic Kashiwanoha
RECRUITING

Chiba, Japan
Clinica Universidad de Navarra
RECRUITING

Pamplona, 31008, Spain
Cliniques Universitaires Saint-Luc Avenue Hippocrate 10
RECRUITING

Woluwe-Saint-Lambert, 1200, Belgium
Colorado ENT & Allergy
RECRUITING

Colorado Springs, Colorado, 80923, United States
DaVinci Research LLC
RECRUITING

Roseville, California, 95661, United States
Delta Health Care S.R.L
RECRUITING

Bucharest, 14142, Romania
Delta Health Care S.R.L
RECRUITING

Bucharest, 14142, Romania
Department otorhinolaryngology - Head and Neck Surgery, Helsinki Univerity Hospital
NOT_YET_RECRUITING

Helsinki, 00130, Finland
Departmentof Allergy, Skin and Allergy Hospital, Helsinki Univerity Hospital
NOT_YET_RECRUITING

Helsinki, 00250, Finland
Diagnostic-Consultative Centre Ascendent EOOD
RECRUITING

Sofia, 1202, Bulgaria
EMC INSTYTUT MEDYCZNY S.A. Przychodnia
RECRUITING

Wroclaw, 50-220, Poland
EMEDR
RECRUITING

Overland Park, Kansas, 66211, United States
Ear Nose and Throat Associates of Texas PA
RECRUITING

McKinney, Texas, 75070-5735, United States
Eastern Virginia Medical School
RECRUITING

Norfolk, Virginia, 23507, United States
Entopy Research LLC
RECRUITING

Chicago, Illinois, 60616, United States
Equity Medical
RECRUITING

The Bronx, New York, 10455, United States
First People's Hospital of Yinchuan
RECRUITING

Yinchuan, 750002, China
Fondazione Policlinico A. Gemelli IRCCS
RECRUITING

Rome, 800168, Italy
Fundacion CIDEA
RECRUITING

Caba, C1121ABE, Argentina
Fundacion Respirar
RECRUITING

Buenos Aires, C1426BP, Argentina
FutureMeds DKF
RECRUITING

Madrid, 28002, Spain
Guys and St Thomas' NHS Foundation Trust
RECRUITING

London, SE1 7EH, United Kingdom
HNO Praxis
RECRUITING

Sachsen, 01067, Germany
HNO Zentrum am Kudamm
RECRUITING

Berlin, 10629, Germany
Hainan General Hospital
NOT_YET_RECRUITING

Haikou, 570311, China
Hangzhou First People's Hospital
RECRUITING

Hangzhou, China
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital
RECRUITING

Hokkaido, 060-0033, Japan
Hospital Clínico Universitario de Santiago
NOT_YET_RECRUITING

Galícia, 15706, Spain
Hospital Pedro Hispano
RECRUITING

Senhora da Hora, 4464-513, Portugal
Hospital Universitario Fundación Jiménez Díaz
RECRUITING

Madrid, 28040, Spain
Hospital Universitario Virgen de la Macarena Avenida Dr. Fedriani
RECRUITING

Andalucia, 41009, Spain
Hospital Universitario de Jerez
RECRUITING

Cadiz, 11407, Spain
Huai'an First People's Hospital
RECRUITING

Huai'an, 223300, China
Humboldt 302 Col. Centro
NOT_YET_RECRUITING

Oaxaca City, 68000, Mexico
Hyogo Medical University Hospital
RECRUITING

Hyōgo, 663-8131, Japan
IKF Pneumologie
RECRUITING

Frankfurt am Main, 60596, Germany
Ibaraki Prefectural Central Hospital
RECRUITING

Ibaraki, Japan
Inje University Haeundae Paik Hospital
RECRUITING

Busan, 48108, South Korea
Investigaciones en Patologías Respiratorias SRL
RECRUITING

San Miguel de Tucumán, CP4000, Argentina
JCHO Shimonoseki Medical center
RECRUITING

Yamaguchi, 750-0061, Japan
James Paget University Hospitals NHS Foundation Trust
RECRUITING

Great Yarmouth, NR31 6LA, United Kingdom
Japan Community Health care Organization Osaka Hospital
RECRUITING

Osaka, 553-0003, Japan
Kagoshima Kouseiren Hospital
RECRUITING

Kagoshima, 890-0062, Japan
Kansai Electric Power Hospital
RECRUITING

Osaka, 553-0003, Japan
Kansai Medical University Hospital
RECRUITING

Hirakata, 573-1191, Japan
Keck Medicine of USC
NOT_YET_RECRUITING

Arcadia, California, 91007, United States
Kimitsu Chuo Hospital
RECRUITING

Kisarazu, 292-8535, Japan
Komarom-Esztergom Varmegyei Szent Borbala Korhaz
RECRUITING

Tatabánya, H-2800, Hungary
Korea University Anam Hospital
RECRUITING

Seoul, 02841, South Korea
Korea University Guro Hospital
NOT_YET_RECRUITING

Seoul, 08308, South Korea
Kyosai Hospital
RECRUITING

Minami-Alps, 400-0405, Japan
Kyushu University Hospital
RECRUITING

Fukuoka, 812-8582, Japan
MJ Research
NOT_YET_RECRUITING

Tampa, Florida, 33615, United States
Madison ENT & Facial Plastic Surgery
RECRUITING

New York, New York, 10016, United States
Matsuda Hospital
RECRUITING

Fukuoka, 812-0053, Japan
Medical Center Medconsult Pleven OOD
RECRUITING

Pleven, 5800, Bulgaria
Medical University of South Carolina- Department of Otolaryngology and Head and Neck Surgery
NOT_YET_RECRUITING

Charleston, South Carolina, 29425, United States
Medovation Research
NOT_YET_RECRUITING

Huntsville, Alabama, 35801, United States
Mie University Hospital
RECRUITING

Tsu, 514-8507, Japan
Miguel Hidalgo 2525, Consultorio 2 Urgencias
RECRUITING

Nuevo León, 64060, Mexico
Military Medical Academy - Multiprofile Hospital for Active Treatment - Sofia,
NOT_YET_RECRUITING

Sofia, 1431, Bulgaria
Multiprofile Hospital For Active Treatment Dr Tota Venkova A
RECRUITING

Gabrovo, 1431, Bulgaria
Multiprofile Hospital for Active treatment Trakia EOOD
NOT_YET_RECRUITING

Zagora, 1504, Bulgaria
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan
New York Allergy and Sinus Center
RECRUITING

New York, New York, 10016, United States
Newcastle upon Tyne Hospitals NHSFT Freeman Hospital
RECRUITING

Newcastle upon Tyne, NE7 7DN, United Kingdom
Niepubliczny Zakład Opieki Zdrowotnej E-Vita
RECRUITING

Bialystok, 15-879, Poland
Nihon University Itabashi Hospital
RECRUITING

Tokyo, 173-0032, Japan
Niigata University Medical & Dental Hospital
RECRUITING

Niigata, 951-8520, Japan
Ningbo Medical Center Lihuili Hospital
NOT_YET_RECRUITING

Ningbo, China
Novak Clinical Research - Tucson - North La Cholla Boulevard
RECRUITING

Tucson, Arizona, 85741, United States
NuLine Clinical Trial Center
NOT_YET_RECRUITING

Pompano Beach, Florida, 33060, United States
Odawara Municipal Hospital
RECRUITING

Kanagawa, 250-8558, Japan
Optimed Research, LTD
RECRUITING

Columbus, Ohio, 43235, United States
Orlando ENT & Allergy
NOT_YET_RECRUITING

Orlando, Florida, 32825, United States
Osaka Habikino Medical Center
RECRUITING

Habikino-shi, 583-8588, Japan
Ospedale San Raffaele
NOT_YET_RECRUITING

Milan, 20132, Italy
Peking University Third Hospital
RECRUITING

Beijing, 100191, China
Pneumocare
RECRUITING

Erpent, 5101, Belgium
Policonsultorio CEPIR
RECRUITING

Buenos Aires, B1904CUL., Argentina
Praxis für HNO und Allergologie
RECRUITING

Dresden, 01139, Germany
Pusan National University Hospital
RECRUITING

Pusan, 49241, South Korea
Renmin Hospital of Wuhan University
RECRUITING

Wuhan, 430060, China
Richmond Ear Nose and Throat
NOT_YET_RECRUITING

Richmond, Virginia, 23235, United States
Ritsuzankai Iida Hospital
RECRUITING

Nagano, 395-0056, Japan
Royal Berkshire NHS Foundation Trust
RECRUITING

London, RG1 5AN, United Kingdom
SMG-SNU Boramae Medical Center
RECRUITING

Seoul, 7061, South Korea
SNUH - Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Saiseikai Fukuoka General Hospital
RECRUITING

Fukuoak, 810-0001, Japan
Seoul National University Bundang Hospital
RECRUITING

Seongnam-si, 13620, South Korea
Shengjing Hospital of China Medical University
RECRUITING

Shenyang, 110004, China
Shenzhen Second People's Hospital
RECRUITING

Guangdong, China
Sichuan Provincial People's Hospital
RECRUITING

Chengdu, 610072, China
Sjællands Universitets Hospital
RECRUITING

Køge, Denmark
South Louisiana Ear, Nose, Throat & Facial Plastic Surgery - PPDS
RECRUITING

Mandeville, Louisiana, 70471, United States
Specjalistyczny Niepubliczny Zakład Opieki Zdrowotnej Alergologia Plus Ośrodek Diagnostyki
RECRUITING

Poznan, 60-693, Poland
St Paul's Sinus Centre
NOT_YET_RECRUITING

Vancouver, V6Z 1Y6, Canada
St. Joseph's Hospital
RECRUITING

Ontario, N6A 4V2, Canada
Stepping Hill Hospital
RECRUITING

Stockport, SK2 7JE, United Kingdom
Taipei Medical University Shuang Ho Hospital
RECRUITING

New Taipei City, 23561, Taiwan
Takarazuka City Hospital
RECRUITING

Hyōgo, 665-0827, Japan
The 2nd Affiliated Hospital of Wenzhou Medical University
RECRUITING

Wenzhou Avenue, 325038, China
The Affiliated Hospital of Xuzhou Medical University
RECRUITING

Xuzhou, 221006, China
The Catholic University of Korea
RECRUITING

Seoul, 06591, South Korea
The First Affiliated Hospital Of Fujian Medical University
RECRUITING

Fuzhou, 350000, China
The First Affiliated Hospital of Bengbu Medical College
NOT_YET_RECRUITING

Bengbu, 233004, China
The First Affiliated Hospital of Nanchang University
RECRUITING

Nanchang, 330006, China
The First Hospital of Shanxi Medical University
RECRUITING

Taiyuan, 30001, China
The First People's Hospital of Foshan
RECRUITING

Foshan, 528000, China
The Gordon and Leslie Diamond Health Care Centre
NOT_YET_RECRUITING

Vancouver, V5Z 1M9, Canada
The Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226-3548, United States
The People's Hospital of Guangxi Zhuang Autonomous Region
RECRUITING

Nanning, 530021, China
The Third Xiangya Hospital of Central South University
RECRUITING

Changsha, 410013, China
The first Affilliated Hospital Shandong First Medical University
RECRUITING

Shandong, 250014, China
Tianjin People's Hospital
RECRUITING

Tianjin, 300121, China
Toho University Ohashi Medical Center
RECRUITING

Tokyo, 153-8515, Japan
Toho University Sakura Medical Center
RECRUITING

Sakura, 285-0841, Japan
Tohoku Medical and Pharmaceutical University Hospital
RECRUITING

Miyagi, Japan
Tokai University Hospital
RECRUITING

Kanagawa, 259-1193, Japan
Tonghua Central Hospital
NOT_YET_RECRUITING

Tonghua, 134001, China
Tongji Hospital of Tongji University
RECRUITING

Shanghai, China
Toyota Memorial Hospital
RECRUITING

Aichi, Japan
Treasure Valley Medical Research
RECRUITING

Boise, Idaho, 83706, United States
UCMC
NOT_YET_RECRUITING

Cincinnati, Ohio, 45267, United States
ULS da Região de Aveiro, EPE - Hospital Infante D. Pedro
RECRUITING

Aveiro, 3814-501, Portugal
ULS do Algarve, EPE - Hospital de Portimão
RECRUITING

Seco Portimao Faro, 8500-338, Portugal
UT Southwestern Medical Center
NOT_YET_RECRUITING

Dallas, Texas, 75390-9035, United States
UZ Gent
RECRUITING

Ghent, 9000, Belgium
Ujpesti Egeszsegugyi Szolgaltato
RECRUITING

Budapest, 1046, Hungary
Unidade Local de Saúde Loures-Odivelas
RECRUITING

Loures, Portugal
Unidade Local de Saúde de Almada-Seixal, E.P.E.
NOT_YET_RECRUITING

Almada, Portugal
Union Hospital Tongji Medical College Huazhong University of Science and Technology
RECRUITING

Wuhan, 430022, China
University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna
RECRUITING

Sofia, 1527, Bulgaria
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35233, United States
University of California, Irvine
RECRUITING

Irvine, California, 92697, United States
University of Fukui Hospital
RECRUITING

Fukui, Japan
University of Missouri
RECRUITING

Columbia, Missouri, 65212, United States
University of South Florida
RECRUITING

Tampa, Florida, 33613, United States
University of Texas Physicians Department of Otorhinolaryngology Clinc
RECRUITING

Houston, Texas, 77030, United States
University of Yamanashi Hospital
RECRUITING

Chūō, 409-3821, Japan
Universitätsklinikum Carl Gustav Carus an der TU Dresden
RECRUITING

Dresden, 74, 01307, Germany
Universitätsklinikum Jena
NOT_YET_RECRUITING

Jena, 07747, Germany
Universitätsklinikum Schleswig-Holstein
NOT_YET_RECRUITING

Lübeck, 23538, Germany
WIM-PIB
RECRUITING

Warsaw, Poland
Washington University School of Medicine
NOT_YET_RECRUITING

St Louis, Missouri, 63141, United States
Yamaguchi University Hospital
RECRUITING

Yamaguchi, 755-8505, Japan
Yokohama City Minato Red Cross Hospital
RECRUITING

Kanagawa, 231-0801, Japan
Yokohama Minami Kyosai Hospital
RECRUITING

Yokohama, 236-0037, Japan

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