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Engineered immune cells take on Hard-to-Treat blood cancer

NCT ID NCT03758417

First seen Nov 01, 2025 · Last updated May 23, 2026 · Updated 32 times

Summary

This study tested a new treatment called LCAR-B38M CAR-T cells in 123 Chinese adults with multiple myeloma that had returned or not responded to at least three prior therapies. The therapy uses a patient's own immune cells, modified to target a protein called BCMA on myeloma cells. The main goal was to see how many patients achieved at least a partial response, while also monitoring side effects.

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Contacts and locations

Locations

  • Fujian Medical University Union hospital

    Fuzhou, Fujian, 350001, China

  • Jiangsu Province Hospital

    Nanjing, Jiangsu, 210029, China

  • Nanjing Drum Tower Hospital

    Nanjing, Jiangsu, 210008, China

  • Peking University Third Hospital

    Beijing, Beijing Municipality, 100191, China

  • Ruijin Hospital, Shanghai Jiao Tong University

    Shanghai, Shanghai Municipality, 200025, China

  • Shanghai Changzheng Hospital

    Shanghai, Shanghai Municipality, 200003, China

  • Shanghai Fourth People Hospital

    Shanghai, Shanghai Municipality, 200434, China

  • Sun Yat -Sen University Cancer Center

    Guandong, Guangzhou, 510060, China

  • The First Affiliated Hospital, Medical School of Zhejiang University

    Hangzhou, Zhejiang, 310003, China

  • The Second Affiliated Hospital of Xi'an Jiaotong University

    Xi’an, Shanxi, 710004, China

  • West China Hospital, Sichuan University

    Chengdu, Sichuan, 610041, China

Conditions

Explore the condition pages connected to this study.