Laser precision could transform oral cancer prevention surgery
NCT ID NCT07678281
First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time
Summary
This trial compares two surgical methods for removing oral epithelial dysplasia, a precancerous condition of the mouth lining. One group receives laser surgery, while the other has traditional scalpel removal. Researchers measure wound healing speed, swelling, redness, and pain to see which approach leads to a smoother recovery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- fiber laser (1.94 micrometers)
- What this could lead to
- If laser surgery proves better, it could become a standard, less painful option for removing precancerous mouth lesions.
- What could go wrong
- This is a small, early-stage trial (74 people) comparing two surgical techniques, so results may not apply broadly. Laser surgery may not improve healing or pain enough to justify its cost.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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74 people
The number who actually took part.
- Started
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Nov 2020
- Finished
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Nov 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. The patient's written informed consent to participate in the study; 2. Men and women aged 18-80 years; 3. Verified diagnoses K 13.2 "Leukoplakia and other changes in the oral epithelium", L 43 "Lichen planus" with pathohistological signs of epithelial dysplasia. 4. Patients who, after conservative treatment of lesions of the oral mucosa, have not achieved a therapeutic effect and have indications for surgery. Non-inclusion criteria: 1. Patients who have achieved the therapeutic effect of the disease after conservative treatment; 2. Patients who have symptoms of malignant transformation and who could not / did not want to make all necessary visits to the doctor; 3. Pregnant women and during lactation, women who planned pregnancy during this study. Exclusion Criteria: 1. Patient's refusal to continue participating in the study; 2. Pregnancy; 3. The onset of an exacerbation of concomitant pathology; 4. Allergic reaction to medications used; 5. A change in the state of health that, in the researcher's opinion, prevents the patient from continuing to participate in the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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I.M. Sechenov First Moscow State Medical University (Sechenov University)
Moscow, Russia
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