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New study tests laser and Air-Polishing to save failing dental implants

NCT ID NCT03451981

Disease control Sponsor: Università Vita-Salute San Raffaele Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

Peri-implantitis is a common gum infection around dental implants that can lead to bone loss and implant failure. This study tested whether adding Er:YAG laser or erythritol air-polishing to standard mechanical cleaning improves outcomes. Forty-seven adults with at least one affected implant received one of the three treatments. The goal was to reduce pocket depth and bleeding, key signs of disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Er:YAG laser or erythritol air-polishing
What this could lead to
If successful, this could point toward a more effective non-surgical treatment for peri-implantitis, reducing the need for surgery.
What could go wrong
This is a small, completed trial with only 47 participants, so results may not apply to everyone. The improvements may be modest and not prevent disease relapse.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

47 people

The number who actually took part.

Started

Dec 2018

Finished

Oct 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * presence of at least one screw-type titanium implant exhibiting bleeding and/or suppuration on probing combined with: 1. a PPD ≥ 5 mm and bone loss \> 2 mm (compared to crestal bone levels at the time of placement of the reconstruction) 2. a PPD ≥ 6 mm and bone loss ≥ 3 mm (not compared to crestal bone levels at the time of placement of the reconstruction) * single tooth and bridgework restorations without overhangings * no evidence of occlusal overload (i.e. occlusal contacts revealed appropriate adjustment) * implant function time ≥ 1 year. Exclusion Criteria: * Patients with uncontrolled diabetes, * patients with osteoporosis or under bisphosphonate medication, * pregnant or lactating women, * patients with a history of radiotherapy to the head and neck region * patients with incapability to perform basal oral hygiene measures due to physical or mental disorders * hollow implants * implant mobility * implants at which no position could be identified where proper probing measurements could be performed; * previous surgical treatment of the peri-implantitis lesions

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Conditions

The condition(s) this trial relates to.

Peri-Implantitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Peri-implantitis

Contacts and locations

Locations

  • Università Vita-Salute San Raffaele

    Milan, Milano, 20100, Italy

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Other studies related to the condition(s) this trial covers.