Can laser beams ease your aching knees?
NCT ID NCT06654739
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tests whether adding laser therapy to standard physiotherapy and exercise reduces knee osteoarthritis pain more than a sham (fake) laser plus exercise. Sixty-four adults with knee osteoarthritis will receive either real or sham laser treatments twice a week for six weeks. The main goal is to measure pain changes using a standard pain scale.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- laser therapy (LightForce® Therapy Lasers) plus physiotherapy/exercise
- What this could lead to
- If it works, this could offer a non-drug, non-surgical option to ease knee osteoarthritis pain.
- What could go wrong
- This is a small, early-stage study with only 64 participants. The laser may not prove more effective than sham treatment, and results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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64 people
The number who actually took part.
- Started
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Nov 2024
- Expected to finish
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Mar 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient male or female with age ≥18 years old * Patient with radiographic diagnosis of knee osteoarthritis (as confirmed by x- ray or CT scan) to be treated by LightForce® Therapy Lasers according its indications. * Patient with Kellgren and Lawrence grade 2-3 unilateral or bilateral knee osteoarthritis * Patient suffering from knee osteoarthritis pain for more than 6 months prior to enrollment * Pain (either persistent or during activities) score reported by the subject at baseline ≥ 40 mm measured on VAS * Patient able to provide written informed consent * Patient with BMI ≤30 kg/m2 * For FRANCE ONLY: To be affiliated to the social security system or to be beneficiary of such system Exclusion Criteria: * Patient with musculoskeletal pathological conditions not to be treated with/contraindication to the use of LightForce® Therapy Lasers according to its intended use and indications * Patients who are taking drugs that have heat or light sensitive contraindications, such as but not limited to certain types of steroids * Patients who are administered with corticosteroids, should discontinue the treatment at least 2 weeks prior to study treatment start * Pregnant females or females of childbearing potentially planning to become pregnant during the study participation * Patients who had inflammatory arthritis (i.e. rheumatoid arthritis, psoriatic arthritis) * Patients who underwent intra-articular injection (Ialuronic acid, platelet rich plasma or corticosteroids) in the knee in the last 6 months * Patients who have a disease that would limit their participation in exercises (i.e. severe chronic obstructive pulmonary disease, severe heart failure, cerebrovascular event history) * Patients who have hip or ankle/foot joint pathology that might interfere with participation in exercises/knee recovery * Patients with a diagnosis of active cancer * Patients with tattoos covering more than 30% of the area to be treated with LightForce® Therapy Lasers * Patients who are mentally or physically incapacitated * Patient participating in other clinical study or has completed a clinical study less than 30 days prior to enrollment * Patients with other musculoskeletal problems of the knee joint such as tendon or ligament injury, recent surgery, recent fracture, or recent meniscus injury and/or undergoing to specific physiotherapy for these ("recent" is defined as within 30 days prior to enrollment) * Patients with other clinically significant co-morbidities that make the patient unsuitable for study participation, at the discretion of the investigator.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Cabinet Allaire
Le Havre, 76600, France
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Cabinet d'Ostéopathie
Grésy-sur-Aix, 73100, France
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Casertafisio
Caserta, Italy
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Fisioterapia Carioni
Milan, Italy
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Fisioterapia EUR
Roma, Italy
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Fisioterapia Gardenie
Roma, Italy
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Indergaard Physiotherapy
Leeds, United Kingdom
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