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New laser zaps away Smoker's lines in minutes

NCT ID NCT07222397

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a special laser (2910 nm) to treat deep wrinkles around the mouth in 20 adults aged 50-80. Participants get up to two treatments, with follow-ups at 1 and 3 months. Doctors and independent reviewers will check if the wrinkles look better, and track any side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
2910 nm erbium-doped fluoride fiber glass laser (UltraClear)
What this could lead to
If it works, this could offer a safe, effective laser option for reducing deep wrinkles around the mouth without surgery.
What could go wrong
This is a very small early trial with only 20 participants, so results may not apply to everyone. The laser may cause temporary redness or swelling, and improvement may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2025

Expected to finish

Feb 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Fitzpatrick skin type I-IV. 2. Male or female. 3. Subjects must be between 50 and 80 years of age. 4. Subjects must have the ability to receive up to two full face resurfacing laser treatment with specific focus on advanced perioral lines and wrinkles. 5. Subjects must read, understand, and sign the Informed Consent Form. 6. Subjects must be willing and able to comply with all follow-up visit requirements. 7. Subjects must agree to refrain from using cosmeceutical agents or topical agents during the study, except as directed by study investigator. 8. Subjects must be rated as Class II or Class III based on the Fitzpatrick Wrinkling and Degree of Elastosis Scale (FWS). 9. Subject identified as an appropriate candidate for study treatment based on principal investigator's opinion. 10. Subjects of childbearing potential have been on an acceptable form of contraception for 30 days prior to enrollment and agree to continue using throughout the course of the study. Exclusion Criteria: 1. Subjects must not have active localized or systemic infections. 2. Subjects must not have a compromised ability for wound healing, such as: malnutrition, steroid use, history of collagen vascular disease (e.g., lupus, scleroderma, history of keloid scar formation), atrophic dermatitis or immunologic abnormalities such as vitiligo. 3. Subjects must not have had treatments with 5FU, diclofenac, imiquimod, steroids, retinoids, or PDT within 1-month prior to enrollment. 4. Subjects must not currently be taking Accutane or have taken Accutane within the last 1-month. 5. Subjects must not have a known allergy to lidocaine or epinephrine, topical or injectable products containing lidocaine or any numbing medications. 6. Subjects must not have had previous surgery and/or fat transfer in the treatment area within the last 6-months. 7. Subject must not have had injectable soft tissue fillers within the last 12 months in the treatment area. 8. Subject must not have had Poly-L-Lactic acid (PLLA) fillers within the last 2 years in the treatment area. 9. Subject must not have had permanent filler i.e., Polymethylmethacrylate (PMMA) in the treatment area. 10. Subjects must not have had neurotoxins within the last 3-months in the treatment area. 11. Subject must not have a personal history of any facial threads i.e., PDO (Polydioxanone), PLLA (Polylactic acid), PCL (Polycaprolactone) in the treatment area within the last 12 months. 12. Subject must not have had a pulse dye or vascular laser, non-ablative laser, microneedling, or energy-based device treatment in the treatment area within the last 3 months. 13. Subject must not have had an ablative laser treatment in the treatment area within the last 6 months. 14. Subjects must not have a personal history of malignant melanoma, keloid scars, generalized psoriasis or systemic diseases that would preclude the use of topical anesthesia. 15. Subject must not have active sunburn or excessively tanned skin. 16. Subjects must not be pregnant or breastfeeding, think they may be pregnant or are trying to get pregnant during the study.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Dermatology & Laser Surgery Center

    RECRUITING

    Houston, Texas, 77030, United States

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