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Nerve block combo may tame inflammation after knee surgery

NCT ID NCT07367009

Knowledge-focused Sponsor: Fatih Sultan Mehmet Training and Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether adding an extra nerve block to the usual pain block can reduce inflammation after total knee replacement. Researchers will measure inflammation markers in the blood of 60 adults. The goal is to see if this approach leads to less pain medicine use and better recovery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients aged 18 years and older, scheduled for elective unilateral total knee arthroplasty under spinal anesthesia (SA), classified as American Society of Anesthesiologists (ASA) physical status I-III, and who provided written informed consent after being informed one day before surgery on the ward, will be included.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * • Patients scheduled for elective unilateral total knee arthroplasty under spinal anesthesia * Aged 18 years and older * Body mass index (BMI) \<40 kg/m² * ASA physical status I-III * Provision of written informed consent Exclusion Criteria:• Emergency surgery * Revision or bilateral surgery * General anesthesia or conversion to general anesthesia due to failed block * BMI ≥40 kg/m² * ASA physical status \>III * Local infection, hematoma, previous surgery, or deformity at the block site * Coagulopathy or history of hematologic, renal, or hepatic disease; advanced respiratory or cardiac failure; malignancy * Use of anticoagulant therapy * History of local anesthetic allergy or toxicity * Impaired cooperation, Alzheimer's disease, dementia, psychiatric or neurological disorders, or language/communication barriers * Chronic analgesic use, chronic alcohol consumption, or substance abuse * Refusal to participate in the study

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Total knee anthroplasty

Contacts and locations

Locations

  • Fatih Sultan Mehmet Training and Research Hospital

    Istanbul, ataşehir, 34752, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.