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Can hip exercises protect knee cartilage in osteoarthritis?

NCT ID NCT07657481

Disease control Sponsor: Pamukkale University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial investigates whether adding hip strengthening exercises to a standard quadriceps program better preserves knee cartilage thickness and improves symptoms in people with knee osteoarthritis. Fifty-six adults with mild-to-moderate knee OA will be randomly assigned to one of two home exercise routines. Researchers will use ultrasound to measure cartilage changes at 1 and 3 months, alongside pain and function assessments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
home exercise program (quadriceps strengthening with or without hip abductor/adductor exercises)
What this could lead to
If hip exercises prove more effective, this could lead to better non-surgical treatments for knee osteoarthritis that preserve cartilage and reduce pain.
What could go wrong
This is a small, early-stage trial with only 56 participants, so results may not apply broadly. Exercise programs rely on patient adherence, and cartilage changes may be minimal.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 56 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥18 years 2. Diagnosis of knee osteoarthritis according to ACR criteria, Kellgren-Lawrence grade 2-3 3. Knee pain for at least 3 months 4. Having the physical capacity to perform a home exercise program 5. Willingness to provide written informed consent Exclusion Criteria: 1. History of knee, hip, or spine surgery 2. Active inflammatory arthritis (e.g., rheumatoid arthritis, gout, psoriatic arthritis) 3. Intra-articular injection within the last 3 months 4. Neurological or neuromuscular disorders 5. Body mass index (BMI) \> 40 kg/m² 6. Pregnancy 7. Cardiovascular or orthopedic contraindications preventing participation in a regular exercise program 8. Cognitive impairment

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteo arthritis of the knee

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Kütahya Physical Therapy and Rehabilitation Hospital

    Kütahya, Turkey (Türkiye)

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