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Knee cartilage surgery showdown: which technique wins?

NCT ID NCT05651997

Disease control Sponsor: Centre Hospitalier Universitaire Vaudois Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two surgical methods for repairing large cartilage defects in the knee: augmented microfracture (AMT) and matrix-assisted chondrocyte implantation (MACT). It will enroll 80 people aged 15-50 with symptomatic defects. The goal is to see which technique better improves knee function and quality of life.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2026

An estimate. Start dates often move.

Expected to finish

Jun 2032

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

15 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged between 15-50 years * Symptomatic chondral and osteochondral defect, grade III and IV according to the ICRS classification, and size between 2.5 and 15 cm2 * Failure of a conservative treatment * Patient in good general condition, documented by an ASA score ≤ 2 (American Society of Anesthesiologists) * Patient considered compliant and able to participate in rehabilitation and pre- and post-operative follow-up * Consent to participate in the study Exclusion Criteria: * All inflammatory and synovial pathologies * Diffuse or mirror lesions * An unfavorable biomechanical environment * Obesity grade II or higher, with a BMI\>35 kg/m2 * Active smoking/ active drug dependency (hard drugs) * Poor compliance * The patient is already part of another clinical trial that may compromise the present study * Vulnerable populations (except minors aged 15-18 years) * Presence of open growth plate (15-18 years) * Pregnancy or planned pregnancy during the study (MRI-related contra-indication) * Proven allergy to penicillin and gentamicin (for MACT group) and porcine collagen (for both groups) For final inclusion, an additional exclusion criteria will be assessed after randomization: \- Positive to HIV, HBV, HCV, syphilis.

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Conditions

The condition(s) this trial relates to.

articular cartilage disorder chondromalacia Osteochondritis osteochondrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Articular cartilage defect Chondral defect Osteochondritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Centre Hospitalier Universitaire Vaudois - CHUV

    Lausanne, Canton of Vaud, 1011, Switzerland

  • Hôpital Fribourgeois- HFR

    Fribourg, Canton of Fribourg, 1708, Switzerland

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