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Which nerve block eases knee replacement pain best?

NCT ID NCT07171931

First seen Nov 01, 2025 · Last updated Jun 22, 2026 · Updated 34 times

Summary

This study compares two types of nerve blocks (genicular block and IPACK block) given alongside a standard adductor canal block to control pain after total knee replacement. 72 adults having knee surgery will receive one of the two blocks, and researchers will measure how much morphine they need afterward. The goal is to find which block provides better pain relief while preserving leg strength for early movement.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

bupivacaine

What this could lead to

If one block works better, it could improve pain relief and reduce opioid use after knee replacement, helping patients recover faster.

What could go wrong

This is a small, early-stage study (72 patients) comparing two similar procedures. It may not find a clear winner, and results may not apply to all patients.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.