New cancer drug targets specific tumor mutations in early human trial

NCT ID NCT04913285

Ongoing Disease control Sponsor: Pierre Fabre Medicament Source: ClinicalTrials.gov ↗

Summary

This early-stage clinical trial is testing a new oral drug called KIN-2787, both alone and in combination with another cancer drug called binimetinib. The study aims to find safe doses and see if the treatment can shrink tumors in adults with advanced solid tumors (like lung cancer or melanoma) that have specific BRAF or NRAS genetic mutations. Researchers will enroll about 400 participants to determine the best dose for future studies and gather initial evidence about the treatment's effectiveness.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

APHM-CHU La Timone

Marseille, France
APHP - Hôpital St Louis

Paris, France
Arance

Barcelona, Spain, Spain
Atlantic Health

Morristown, New Jersey, 07960, United States
Austin Health

Heidelberg, Victoria, 3084, Australia
Beijing University Cancer Hospital

Beijing, 100142, China
Berrocal

Valencia, Spain, Spain
CHU Nantes-Hotel Dieu

Nantes, France
CHU de Lille

Lille, France
CHU de Nice - Hôpital Archet 2

Nice, France
CHU de Poitiers

Poitiers, France
Calvary Mater Hospital Newcastle

Waratah, New South Wales, 2298, Australia
Centre Francois Baclesse

Caen, France
Centre Leon Berard

Lyon, France
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Gustave Roussy

Villejuif, 94805, France
H. Regional de Málaga

Málaga, Spain, Spain
H. Virgen Macarena

Seville, Spain, Spain
Harbin Medical University Cancer Hospital

Haerbin, Heilongjiang, 150081, China
Hospices Civiles de Lyon - Hôpital Lyon Sud

Pierre-Bénite, France
Hospital General Gregorio Marañón

Madrid, 29009, Spain
Hospital Quiron Dexeus

Barcelona, Spain
Hospital Universitario Insular de Gran Canaria

Las Palmas de Gran Canaria, Spain
INCLIVA (Hospital Clinico de Valencia)

Valencia, Spain
Institut Bergonie

Bordeaux, France
Istituto Nazionale dei Tumori Fondazione G. Pascale

Naples, 80131, Italy
Linear Clinical Research

Perth, Western Australia, 6009, Australia
Linyi Cancer Hospital

Linyi, Shandong, 276001, China
MD Anderson

Houston, Texas, 77030, United States
Mayo Clinic - Florida

Jacksonville, Florida, 32224, United States
Mayo Clinic - Rochester

Rochester, Minnesota, 55905, United States
Melanoma Institute Australia

Wollstonecraft, New South Wales, 2065, Australia
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
NEXT Quirónsalud Madrid

Madrid, Spain, Spain
NYU Langone

New York, New York, 10016, United States
National Taiwan University Hospital

Taipei, Taiwan
Oncopole Claudius Regaud

Toulouse, 31059, France
Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08901, United States
START Madrid

Madrid, 28050, Spain
Sarah Cannon Research Institute - Florida Cancer Specialists

Orlando, Florida, 32827, United States
Sarah Cannon Research Institute Denver

Denver, Colorado, 80218-1238, United States
Sarah Cannon Research Institute-Tennessee Oncology

Nashville, Tennessee, 37203, United States
Stanford Cancer Center

Stanford, California, 94305, United States
Tasman Health Care

Southport, Queensland, 4215, Australia
The Angeles Clinic

Los Angeles, California, 90025-6602, United States
The Shanghai Pulmonary Hospital

Shanghai, 200433, China
UCLA

Los Angeles, California, 90095, United States
University of California San Diego, Moores Cancer Center

San Diego, California, 92093, United States
University of California San Francisco

San Francisco, California, 94143-2205, United States
Virginia Cancer Specialists

Fairfax, Virginia, 22031, United States

Conditions

Explore the condition pages connected to this study.

MELANOMA NON-SMALL-CELL LUNG CANCER SOLID TUMOR, ADULT